Metals for Biomedical Applications: From Experiments to Computer Models

A special issue of Metals (ISSN 2075-4701). This special issue belongs to the section "Biobased and Biodegradable Metals".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 5909

Special Issue Editor


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Guest Editor
Tecnun - University of Navarra, Donostia-San Sebastian, Spain
Interests: Biomedical engineering; mechanical properties; mechanical testing; degradation; in-silico modelling; computational materials science

Special Issue Information

Dear Colleagues,

One of the main aims of modern societies is to extend the life expectancy of their citizens. However, this extension has no meaning if it is not accompanied with an improvement in life quality, independently of the age range.

To achieve these objectives, the synergy of medicine and engineering is necessary. One of the fields where this collaboration has proven fruitful has been in the field of materials engineering. Biomaterials are the result of this close collaboration.

When talking about biomaterials, at first one can think of polymers. However, these materials do not possess the required properties for many biomedical applications. This is where metals come into play.

Progress in the field of metallic biomaterials requires not only experimentation with these materials, but also theoretical studies and the development of computer models. These studies allow us to understand the properties and response of these metals to the biological environment, helping to optimize biomedical design using them.

This special issue of Metals contemplates the publication of original research papers in the topic of metals as biomaterials. These investigations can be related with:

  • Design
  • Processing and manufacturing
  • Physical/mechanical behaviour
  • Degradation/environment interaction
  • Theoretical models
  • Mathematical modelling
  • Computer simulation
  • Experimental research

Manuscripts on mainly these topics are welcome to be considered for its publication.

Assoc. Prof. Dr. Javier Aldazabal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterial
  • metallic implants
  • manufacturing process
  • additive manufacturing
  • biocompatibility
  • mechanical behaviour
  • degradation
  • computer modelling
  • theoretical model

Published Papers (3 papers)

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Research

8 pages, 3446 KiB  
Article
Influence of the Laser Deposited 316L Single Layers on Corrosion in Physiological Media
by Unai Garate, Enara Mardaras, Rodolfo González, Jon Iñaki Arrizubieta, Garikoitz Artola and Javier Aldazabal
Metals 2022, 12(6), 1047; https://doi.org/10.3390/met12061047 - 19 Jun 2022
Viewed by 1524
Abstract
A multilayer laser-deposited lining of AISI 316L stainless steel makes a regular structural steel surface corrosion resistant in physiological media. Despite the application of single-layer stainless-steel linings being economically beneficial and allowing thinner surface modifications, dilution effects that modify the pitting resistance of [...] Read more.
A multilayer laser-deposited lining of AISI 316L stainless steel makes a regular structural steel surface corrosion resistant in physiological media. Despite the application of single-layer stainless-steel linings being economically beneficial and allowing thinner surface modifications, dilution effects that modify the pitting resistance of the coating must be accounted for. In order to study the feasibility of employing single-layer coatings instead of multilayer coatings for corrosion protection in physiological media, a polarization testing back-to-back comparison was performed between laser-deposited AISI 316L monolayers on 42CrMo4 quenched and tempered steel and cold-rolled AISI 316L sheet in Dulbecco’s Phosphate Buffer Solution at 36 °C. A higher dispersion in pitting resistance, ranging from 800 mV to 1200 mV, was found on the coated samples, whereas the cold-rolled material was more stable in the 1200 mV range. The resulting differences in corrosion rates and pitting potentials open the discussion on whether the chemical composition deviations on AISI 316L dilution layers are acceptable in terms of surface functionality in medical devices. Full article
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12 pages, 3789 KiB  
Article
Degradation of Titanium Sintered with Magnesium: Effect of Hydrogen Uptake
by Vasil M. Garamus, Wolfgang Limberg, Maria Serdechnova, Di Mei, Sviatlana V. Lamaka, Thomas Ebel and Regine Willumeit-Römer
Metals 2021, 11(4), 527; https://doi.org/10.3390/met11040527 - 24 Mar 2021
Cited by 3 | Viewed by 1937
Abstract
Multifunctional materials based on a combination of permanent and degradable metals open new perspectives for medical implants combining osseoconductivity and drug-delivery functions which can significantly decrease the number of implants’ revision. In this work, hybrid magnesium-titanium materials were produced via sintering, and the [...] Read more.
Multifunctional materials based on a combination of permanent and degradable metals open new perspectives for medical implants combining osseoconductivity and drug-delivery functions which can significantly decrease the number of implants’ revision. In this work, hybrid magnesium-titanium materials were produced via sintering, and the properties of the permanent titanium component before and after the degradation of the temporary magnesium part were evaluated. The changes of chemical composition and mechanical parameters were determined. Loading of hydrogen into the titanium part at room temperature was observed, which deteriorated the mechanical characteristics but could also simultaneously improve the biocompatibility of the permanent titanium implant. The control of degradation of the magnesium part and the modification of the titanium part are required for the development of partly degradable hybrid implants. Full article
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14 pages, 2464 KiB  
Article
Manufacturing and Study of Mechanical Properties, Structure and Compatibility with Biological Objects of Plates and Wire from New Ti-25Nb-13Ta-5Zr Alloy
by Sergey V. Gudkov, Alexander V. Simakin, Mikhail A. Sevostyanov, Sergey V. Konushkin, Monika Losertová, Alexander Yu. Ivannikov, Alexey G. Kolmakov and Andrey Yu. Izmailov
Metals 2020, 10(12), 1584; https://doi.org/10.3390/met10121584 - 26 Nov 2020
Cited by 16 | Viewed by 1775
Abstract
A Ti–25Nb–13Ta–5Zr alloy was produced and studied in this work, and plates and wires were made from this alloy. It is shown that the Ti–25Nb–13Ta–5Zr alloy has the required mechanical properties and a β-crystal phase. Microstructures were present on the surface of the [...] Read more.
A Ti–25Nb–13Ta–5Zr alloy was produced and studied in this work, and plates and wires were made from this alloy. It is shown that the Ti–25Nb–13Ta–5Zr alloy has the required mechanical properties and a β-crystal phase. Microstructures were present on the surface of the alloy with a height of several hundred nm, located at a distance of 1.5–2 μm from each other. Ti–25Nb–13Ta–5Zr was superior to nitinol in terms of the formation of long-living reactive protein species and the generation of reactive oxygen species. Cell cultivation on Ti–25Nb–13Ta–5Zr alloy surfaces revealed a significant mitotic index (2%) and a small number of nonviable cells (<5%). The cells were actively attached and spread over the alloy. The biocompatibility of Ti–25Nb–13Ta–5Zr was verified by experiments on the implantation of the alloy in the form of plates and coiled wires. The surface morphology of the specimens after biological trials was not significantly altered. The experimental data we obtained suggest that Ti–25Nb–13Ta–5Zr is suitable for potential applications in biology and medicine. Full article
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