The Role of Hemorheology, Microcirculation, and Metabolism in Clinical Research
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 76
Special Issue Editors
Interests: hemorheology; cardiology; cardiac rehabilitation; sports medicine
Special Issue Information
Dear Colleagues,
Hemorheology is the study of blood flow properties and blood cell interactions. The macrorheological parameters whole blood and plasma viscosity are the main determiners of macro- and microcirculation. However, whole blood viscosity is mainly dependent on hematocrit and plasma viscosity in large vessels, while in microcirculation, especially in capillaries, it is highly influenced by microrheological factors. While the most dominant rheological components in microcirculation are red blood cell aggregation and deformability, other parameters also play a significant role in disease evolution, like leukocyte activation and adhesion in inflammation or platelet aggregation in vascular injury.
Impaired hemorheological parameters are present in various atherosclerosis (inflammation)-mediated cardiovascular, cerebrovascular and peripheral arterial diseases, where microcirculatory impairment could lead to life-threatening complications and low quality of life. For example, diabetes mellitus, which is one of the most important metabolic diseases with known high cardiovascular risk, causing both macro- and microvascular complications, which are also characterized by impaired hemorheological parameters. Due to the negative hemorheological changes that are already present in the primordial phase of atherosclerotic and cardiometabolic diseases, rheological parameters could be early markers of impaired microcirculation, which could be used as a preclinical diagnostic or screening tool.
In this Special Issue, we would like to welcome manuscripts about the influence of drugs, bioactive metabolites and cardiovascular and metabolic diseases on blood flow and red blood cell properties from a diagnostic and/or therapeutical point of view.
The key question is as follows: could altered hemorheological parameters be helpful for better understanding the underlying pathophysiological process in cardiovascular and metabolic disorders?
Dr. Barbara Sándor
Dr. Miklós Rábai
Guest Editors
Manuscript Submission Information
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Keywords
- hemorheology
- microcirculation
- red blood cell properties
- viscosity
- inflammation
- metabolism
