Stem Cell Metabolism and Therapy in Reproductive Endocrinology
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 219
Special Issue Editors
Interests: women health; epigenetic reprogramming; stem cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Stem cell-based therapy has been shown to be beneficial and effective in various degenerative disease conditions. These stem cells have been shown to retain their develop-mental potential following extensive sub-cultivation in vitro. Implantation of culture-expanded mesenchymal stem cells has been demonstrated to effect tissue regeneration in a variety of animal models, and depends on local factors to stimulate differentiation into the appropriate phenotype. Autologous bone marrow stem cells have been used in various female reproductive disorders, such as premature ovarian insufficiency (POI), polycystic ovarian syndrome (PCOS), and endometriosis. Various preclinical and phase I clinical trials have demonstrated that MSCs exert their regenerative properties in ovarian tissue through their paracrine and metabolic mechanisms, such as neo-angiogenic, anti-fibrotic, and anti-apoptotic mechanisms. Additionally, the homing and immune-modulatory properties of MSCs have been leveraged to minimize the rejection and longevity of regeneration potential. Recently, MSC derivatives such as extracellular vesicles (EVs) have gained importance through entering several clinical trials as they offer cell-free therapeutics for regulatory approval.
Gynecological conditions such as uterine fibroids and endometriosis are very common, having a significant impact on women’s quality of life in addition to imposing huge financial burden. Both conditions have been reported to negatively affect women’s fertility and to originate from stem cells in myometrium or endometrium, respectively. Developmental reprogramming of those stem cells can result in their transformation towards disease. Understanding the role of stem cell metabolism and immune modulation in the pathogenesis of these conditions is paramount in developing preventive/therapeutic strategies, especially in women at highest risk due to their ethnicity.
Dr. Mohamed Ali
Dr. Farzana Begum Liakath Ali
Guest Editors
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Keywords
- mesenchymal stem cells
- cell metabolism
- stem cell biology
- exosomes
- tissue regeneration
- ovarian dysfunction
- polycystic ovarian syndrome
- premature ovarian insufficiency
- endometriosis
- leiomyoma
- fertility restoration
