Metabolic Flexibility and Metabolic Engineering Associated with Health and Diseases
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 190
Special Issue Editors
Interests: signaling pathways; diabetes; metabolic flexibility; early programming; obesity; muscle differentiation
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic flexibility; nutritional regulation of gene expression; metabolic engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic flexibility is the capability of a system to regulate fuel oxidation or storage (primarily glucose and fatty acids) in response to nutrient availability. Metabolic flexibility also relies on organ interplay since the liver, adipose tissue and muscles regulate energy homeostasis in a coordinated fashion depending on the caloric intake and energy demand.
Metabolic flexibility has been associated with the context of fuel selection in the transition from fasting to feeding, or from fasting to insulin stimulation to explain insulin resistance. Then, the term metabolic flexibility has changed to incorporate other metabolic circumstances and tissues and more general states of physiological adaptability. Metabolic flexibility is tissue-specific in response to nocturnal and diurnal fasting and feeding conditions.
Exercise is another physiological condition that requires metabolic flexibility so that fuel availability is coupled with the metabolic machinery to cope with huge increases in energy demands. The duration and intensity of exercise can profoundly impact the energy demand, taxing energy reserves and catabolic pathways in different ways.
Specific areas that will be addressed include the impact of metabolic flexibility on different tissues and organs, the metabolic inflexibility in diseases such as Diabetes, Obesity, Cancer, Inflammation, and Non-Alcoholic Fatty Acid Liver Disease. Manuscripts dealing with other pertinent challenging issues are also highly desired.
This Special Issue will familiarize readers with the molecular mechanisms involved in the metabolic flexibility/inflexibility ratio in different physiological or pathological situations and in different organs and tissues.
Prof. Dr. Maria D. Giron-Gonzalez
Prof. Dr. Rafael Salto-Gonzalez
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic flexibility
- metabolic inflexibility
- exercise
- muscle
- liver
- adipose tissue
- insulin resistance
- obesity
- cancer
- metabolic syndrome
- early programming
