23 March 2023
Metabolites | Hot Topic Papers Published in 2021 in the “Pharmacology and Drug Metabolism” Section

  1. “Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages”
    by Alessandro Del Re, Chiara Corpetti, Marcella Pesce, Luisa Seguella, Luca Steardo, Irene Palenca, Sara Rurgo, Barbara De Conno, Giovanni Sarnelli and Giuseppe Esposito
    Metabolites 2021, 11(9), 592;
    Available online:
  1. “Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy”
    by Denisa Bojkova, Rui Costa, Philipp Reus, Marco Bechtel, Mark-Christian Jaboreck, Ruth Olmer, Ulrich Martin, Sandra Ciesek, Martin Michaelis and Jindrich Cinatl, Jr.
    Metabolites 2021, 11(10), 699;
    Available online:
  1. “Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective”
    by Jacob King, Maya Patel and Sriram Chandrasekaran
    Metabolites 2021, 11(11), 792;
    Available online:
  1. “Evaluation of Pharmacokinetic Drug–Drug Interactions: A Review of the Mechanisms, In Vitro and In Silico Approaches”
    by Yaru Peng, Zeneng Cheng and Feifan Xie
    Metabolites 2021, 11(2), 75;
    Available online:
  1. “Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies”
    by Nicolas Kambia, Isabelle Séverin, Amaury Farce, Laurence Dahbi, Thierry Dine, Emmanuel Moreau, Valérie Sautou and Marie-Christine Chagnon
    Metabolites 2021, 11(2), 94;
    Available online:
  1. “Simultaneous Quantitation of Lipid Biomarkers for Inflammatory Bowel Disease Using LC–MS/MS”
    by Yashpal S. Chhonker, Shrey Kanvinde, Rizwan Ahmad, Amar B. Singh, David Oupický and Daryl J. Murry
    Metabolites 2021, 11(2), 106;
    Available online:
  1. “Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control”
    by Malin Nilsson Broberg, Heather Knych, Ulf Bondesson, Curt Pettersson, Scott Stanley, Mario Thevis and Mikael Hedeland
    Metabolites 2021, 11(2), 85;
    Available online:
  1. “Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology”
    by Xiaoguang Liu, Kaluvu Balaraman, Ciarán C. Lynch, Michaeline Hebron, Christian Wolf and Charbel Moussa
    Metabolites 2021, 11(9), 622;
    Available online:

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