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Multifunctional Organic-Inorganic Hybrid Materials for Therapy, Diagnosis and Regenerative Medicine

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2744

Special Issue Editors


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Guest Editor
CNR-ISMN, Via P. Gobetti, 101, 40129 Bologna, Italy
Interests: nanomagnetism; spintronics; magnetic biodevices

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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Enviromental Science, Università degli Studi di Messina, Viale F. Sagno D’ Alcontres 31, 98168 Messina, Italy
Interests: nanomaterials; biomaterials; biodevices
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Special Issue Information

Dear Colleagues,

Innovative multifunctional hybrid materials, merging organic and inorganic components, have proven their high potential in the biomedical field, although the realization of applicable materials and devices still represents a significant technological challenge. This Special Issue aims at highlighting the main progresses in the design, fabrication, and advanced characterizations of such hybrid materials, sheding light on their extraordinary properties and reviewing various proofs of concept and application achievements in the fields of therapy, diagnosis, and regenerative medicine. Special consideration will be given to multifunctional hybrid materials, including those with a stimuli-responsive tailoring, to fight cancer, neurodegeneration, osteoarticular diseases, and bacterial and viral infections. Likewise, significant attention will be paid to assessing accomplishments in the area of bioelectronic and wearable devices, with a special focus on diagnostic and theranostic applications.

Dr. Antonino Mazzaglia
Dr. Valentin Alek Dediu
Prof. Sabrina Conoci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multifunctional hybrid materials
  • Therapy, diagnosis, regenerative medicine
  • Stimuli-responsiveness materials
  • Biosensing
  • Bioelecronic devices
  • Personalized heathcare devices

Published Papers (1 paper)

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Research

16 pages, 5083 KiB  
Article
Silver Nanoparticles Decorated with PEGylated Porphyrins as Potential Theranostic and Sensing Agents
by Angelo Nicosia, Antonio Abbadessa, Fabiana Vento, Antonino Mazzaglia and Placido Giuseppe Mineo
Materials 2021, 14(11), 2764; https://doi.org/10.3390/ma14112764 - 23 May 2021
Cited by 13 | Viewed by 2169
Abstract
Silver nanoparticles (AgNPs) stand out over other metal nanoparticles thanks to their peculiar bactericidal and spectroscopic properties. Tunability of the AgNPs chemical–physical properties could be provided through their organic covalent coating. On the other hand, PEGylated porphyrin derivatives are versatile heteromacrocycles investigated for [...] Read more.
Silver nanoparticles (AgNPs) stand out over other metal nanoparticles thanks to their peculiar bactericidal and spectroscopic properties. Tunability of the AgNPs chemical–physical properties could be provided through their organic covalent coating. On the other hand, PEGylated porphyrin derivatives are versatile heteromacrocycles investigated for uses in the biomedical field as cytotoxic and tracking agents, but also as sensors. In this work, an easy multi-step approach was employed to produce coated silver nanoparticles. Specifically, the AgNPs were functionalized with 5,10,15-[p-(ω-methoxy-polyethyleneoxy)phenyl]-20-(p-hydroxyphenyl)-porphyrin (P(PEG350)3), using chloropropanethiol as a coupling agent. The P(PEG350)3 was structurally characterized through MALDI-TOF mass spectrometry, NMR spectroscopy and thermal analyses. The functionalization of AgNPs was monitored step-by-step employing UV-Vis spectroscopy, dynamic light scattering and thermogravimetric techniques. HRTEM and STEM measurements were used to investigate the morphology and the composition of the resulting nanostructured system (AgNP@P(PEG350)3), observing a long-range alignment of the outer porphyrin layer. The AgNP@P(PEG350)3 combines the features of the P(PEG350)3 with those of AgNPs, producing a potential multifunctional theranostic tool. The nanosystem revealed itself suitable as a removable pH sensor in aqueous solutions and potentially feasible for biological environment applications. Full article
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