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Fundamentals and Applications of Bionano Sensor Techniques
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Fundamentals and Applications of Bionano Sensor Techniques

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 8589

Special Issue Editor

Prof. Dr. Lingxin Chen

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Guest Editor
CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Research Center for Coastal Environmental Engineering and Technology of Shandong Province, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Interests: coastal zone pollutants; typical water body pollutants; microanalysis techniques; environmental microanalysis; oceanic oil spill; situ on-line and real-time environmental monitoring techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoscale biosensors involve bio-elemental related nanostructured sensors, concerning construction and chemo/bioanalysis applications, which can be regarded as one of the most successful branches of nanosensors. The rapidly expanding of nanoscale biosensors is very likely owing to the fast fierce and continuous advancement in nanomaterials and nanostructures, new types of physical supports together with advanced biofunctionalization techniques, new receptors and their applications for analysing representative real samples, making them one of the most advanced and competitive sensing tools. The application scopes of nanoscale biosensors are wide-ranging and very diverse, including food and agriculture, environmental monitoring, clinical diagnostics and therapeutics, life sciences, counterterrorism and safety, and so on.

The aim of this themed collection issue is to cover recent development of nanoscale biosensors combining with diverse detection methods including optical, electrochemical, piezoelectric, etc, as well as chemical analysis related to molecular biology, antigen antibodies, enzymes, proteins and other biological elements. The issue will bring together the recent developments in: smart construction strategies for nanoscale biosensors; innovative optical, electrochemical, piezoelectric, molecular biology, or other detection technologies at the transducer scheme; new nanomaterials and nanostructures; hybrid devices; improvement of sensitivity, miniaturization and multiplexing capabilities; nanoarray formats; sensors based on molecular biology, antigen antibodies, enzymes, proteins,oligonucleotides, peptides and other biological substances, molecularly imprinted polymers, optofluidics, lab-on-chip and point-of-care platforms, etc; new routes of biofunctionalization; protein analysis, single-molecule detection, typical biological contaminants monitoring, and typical chemical pollutants analysis related to bio-materials, covering the full spectrum of possible applications of nanoscale biosensors. Other interesting fundementals and applications of nanoscale biosensors are also welcome.

Prof. Dr. Lingxin Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nonmaterial & Micro biosensors
  • microfluidic devices
  • Nano & Bio interfaces
  • Diagnostics
  • Theranostics sensors

Published Papers (3 papers)

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Research

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14 pages, 3691 KiB  
Article
Multi-Walled Carbon Nanotubes for Magnetic Solid-Phase Extraction of Six Heterocyclic Pesticides in Environmental Water Samples Followed by HPLC-DAD Determination
by Jiping Ma, Liwei Hou, Gege Wu, Liyan Wang, Xiaoyan Wang and Lingxin Chen
Materials 2020, 13(24), 5729; https://doi.org/10.3390/ma13245729 - 15 Dec 2020
Cited by 20 | Viewed by 1978
Abstract
Magnetic multi-walled carbon nanotubes were prepared as magnetic solid-phase extraction (MSPE) adsorbent for the enrichment of six heterocyclic pesticides in environmental water samples, including imidacloprid, triadimefon, fipronil, flusilazole, chlorfenapyr and fenpyroximate. Then six heterocyclic pesticides were separated and determined by high-performance liquid chromatography-diode-array [...] Read more.
Magnetic multi-walled carbon nanotubes were prepared as magnetic solid-phase extraction (MSPE) adsorbent for the enrichment of six heterocyclic pesticides in environmental water samples, including imidacloprid, triadimefon, fipronil, flusilazole, chlorfenapyr and fenpyroximate. Then six heterocyclic pesticides were separated and determined by high-performance liquid chromatography-diode-array detector (HPLC-DAD). Major factors influencing MSPE efficiency, including the dose of mag-multi-walled carbon nanotubes (mag-MWCNTs), extraction time, solution pH, salt concentration, type and volume of eluent and desorption time were investigated. Under the optimized conditions, the enrichment factor of the method reached to 250. The linearity was achieved within 0.05–10.0 μg/L for imidacloprid and chlorfenapyr, 0.10–10.0 μg/L for fipronil, flusilazole, triadimefon and fenpyroximate. Limits of detection were in the range of 0.01–0.03 μg/L. Good precision at three spiked levels were 1.1–11.2% (intra-day) and 1.7–11.0% (inter-day) with relative standard deviation of peak area, respectively. The developed method was utilized to analyze tap water, river water and reservoir water samples and recoveries at three spiked concentration levels ranged from 72.2% to 107.5%. The method was proved to be a convenient, rapid and practical method for sensitive determination of heterocyclic pesticides. Full article
(This article belongs to the Special Issue Fundamentals and Applications of Bionano Sensor Techniques)
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10 pages, 1733 KiB  
Article
A Novel Green Extraction Technique for Extracting Flavonoids from Folium nelumbinis by Changing Osmosis Pressure
by Hai-Yan Fang, Ying-Qin Wei, Meng-Li Zhang and Wei Liu
Materials 2020, 13(18), 4192; https://doi.org/10.3390/ma13184192 - 21 Sep 2020
Cited by 2 | Viewed by 1933
Abstract
A new green and sustainable extraction technique, namely osmosis extraction (OE), was developed for efficient extracting flavonoids from Folium nelumbinis by changing the osmotic pressure. The antioxidant activities of the extracted flavonoids were also evaluated. Ethanol and ammonium sulfate were selected for the [...] Read more.
A new green and sustainable extraction technique, namely osmosis extraction (OE), was developed for efficient extracting flavonoids from Folium nelumbinis by changing the osmotic pressure. The antioxidant activities of the extracted flavonoids were also evaluated. Ethanol and ammonium sulfate were selected for the OE system because they are environmentally friendly. The maximum flavonoids concentration in the top phase was obtained with an ethanol volume fraction of 42.0% and the salt mass of 1.9 g. The kinetic behavior of the extraction process showed that OE had higher efficiencies especially coupled with ultrasonication due to the accompanying and serious morphological changes of Folium nelumbinis cells observed by digital microscope and nano-computed tomography (nano-CT). Results of morphological and anatomical features showed that the higher intracellular chemical potential made the cell expand and even led to bursting. The results also showed that the extraction efficiency of flavonoids with high antioxidant activities was higher than that of the traditional method. The interface effect enhanced the extraction during the salting-out extraction and osmosis was the main factor that improved the extraction efficiency. Full article
(This article belongs to the Special Issue Fundamentals and Applications of Bionano Sensor Techniques)
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Review

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24 pages, 2936 KiB  
Review
Applications of Bionano Sensor for Extracellular Vesicles Analysis
by Jin-Ha Choi, Jin-Ho Lee and Jeong-Woo Choi
Materials 2020, 13(17), 3677; https://doi.org/10.3390/ma13173677 - 21 Aug 2020
Cited by 7 | Viewed by 3880
Abstract
Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases such as cancers. However, due to the structural nature of the EVs, [...] Read more.
Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases such as cancers. However, due to the structural nature of the EVs, the precise isolation and characterization are extremely challenging. To this end, tremendous efforts have been made to develop bionano sensors for the precise and sensitive characterization of EVs from a complex biologic fluid. In this review, we will provide a detailed discussion of recently developed bionano sensors in which EVs analysis applications were achieved, typically in optical and electrochemical methods. We believe that the topics discussed in this review will be useful to provide a concise guideline in the development of bionano sensors for EVs monitoring in the future. The development of a novel strategy to monitor various bio/chemical materials from EVs will provide promising information to understand cellular activities in a more precise manner and accelerates research on both cancer and cell-based therapy. Full article
(This article belongs to the Special Issue Fundamentals and Applications of Bionano Sensor Techniques)
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