Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.4
Journals
Materials
Special Issues
Functional Nanomaterials for Biomedical Applications
materials-logo
Submit to Materials Review for Materials Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Functional Nanomaterials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 January 2023) | Viewed by 13970

Special Issue Editor

Prof. Dr. Fathi Moussa

E-Mail
Guest Editor
Institut de Chimie Physique, CNRS–UMR 8000, Université Paris-Saclay, Gif-sur-Yvette, France
Interests: fullerenes; pharmacy; clinical biology; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

This Special Issue, “Advances in Biomedical Applications of Nanomaterials”, is intended to cover all recent aspects of biomedical applications of nanomaterials, hence providing an overview of the state of the art and perspectives of all potentially usable engineered nanoparticles in the field.

We hope that this Special Issue will serve as a sourcebook, allowing one to learn all aspects and perspectives related to potential applications of nanomaterials in the fields of biology and medicine including, but not limited to, the following:

  • Direct effects on living organisms;
  • Imaging, drug targeting, and theranostics;
  • Transfection;
  • Diagnosis;
  • Drug and medical material preservation;
  • Toxicity;
  • Environmental issues;
  • Quality control;
  • Regulatory considerations.

Papers on other topics associated with advances in manufacturing engineering of nanomaterials for medical purposes are also welcome, provided that the contribution is novel and the paper has been not published elsewhere.

It is our pleasure to invite professionals from industry and from academic and research institutions from around the world to submit their contributions to this Special Issue.

Prof. Dr. Fathi Moussa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanomaterials
  • Nanoparticles
  • Nanomedicine
  • Drug targeting
  • Theranostics
  • Imaging
  • Nanoparticle toxicity
  • In vivo fate of nanomaterials
  • Environmental impact of engineered nanomaterials
  • Quality control and regulatory considerations

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 3025 KiB  
Article
Germanium Nanoparticles Prepared by Laser Ablation in Low Pressure Helium and Nitrogen Atmosphere for Biophotonic Applications
by Anastasiya A. Fronya, Sergey V. Antonenko, Nikita V. Karpov, Nikolay S. Pokryshkin, Anna S. Eremina, Valery G. Yakunin, Alexander Yu. Kharin, Alexander V. Syuy, Valentin S. Volkov, Yaroslava Dombrovska, Alexander A. Garmash, Nikolay I. Kargin, Sergey M. Klimentov, Victor Yu. Timoshenko and Andrei V. Kabashin
Materials 2022, 15(15), 5308; https://doi.org/10.3390/ma15155308 - 02 Aug 2022
Cited by 4 | Viewed by 1628
Abstract
Due to particular physico-chemical characteristics and prominent optical properties, nanostructured germanium (Ge) appears as a promising material for biomedical applications, but its use in biological systems has been limited so far due to the difficulty of preparation of Ge nanostructures in a pure, [...] Read more.
Due to particular physico-chemical characteristics and prominent optical properties, nanostructured germanium (Ge) appears as a promising material for biomedical applications, but its use in biological systems has been limited so far due to the difficulty of preparation of Ge nanostructures in a pure, uncontaminated state. Here, we explored the fabrication of Ge nanoparticles (NPs) using methods of pulsed laser ablation in ambient gas (He or He-N2 mixtures) maintained at low residual pressures (1–5 Torr). We show that the ablated material can be deposited on a substrate (silicon wafer in our case) to form a nanostructured thin film, which can then be ground in ethanol by ultrasound to form a stable suspension of Ge NPs. It was found that these formed NPs have a wide size dispersion, with sizes between a few nm and hundreds of nm, while a subsequent centrifugation step renders possible the selection of one or another NP size fraction. Structural characterization of NPs showed that they are composed of aggregations of Ge crystals, covered by an oxide shell. Solutions of the prepared NPs exhibited largely dominating photoluminescence (PL) around 450 nm, attributed to defects in the germanium oxide shell, while a separated fraction of relatively small (5–10 nm) NPs exhibited a red-shifted PL band around 725 nm under 633 nm excitation, which could be attributed to quantum confinement effects. It was also found that the formed NPs exhibit high absorption in the visible and near-IR spectral ranges and can be strongly heated under photoexcitation in the region of relative tissue transparency, which opens access to phototherapy functionality. Combining imaging and therapy functionalities in the biological transparency window, laser-synthesized Ge NPs present a novel promising object for cancer theranostics. Full article
(This article belongs to the Special Issue Functional Nanomaterials for Biomedical Applications)
►▼ Show Figures

Figure 1

20 pages, 6360 KiB  
Article
Superparamagnetic Iron Oxide Particles (VSOPs) Show Genotoxic Effects but No Functional Impact on Human Adipose Tissue-Derived Stromal Cells (ASCs)
by Katrin Radeloff, Mario Ramos Tirado, Daniel Haddad, Kathrin Breuer, Jana Müller, Sabine Hochmuth, Stephan Hackenberg, Agmal Scherzad, Norbert Kleinsasser and Andreas Radeloff
Materials 2021, 14(2), 263; https://doi.org/10.3390/ma14020263 - 07 Jan 2021
Cited by 5 | Viewed by 1740
Abstract
Adipose tissue-derived stromal cells (ASCs) represent a capable source for cell-based therapeutic approaches. For monitoring a cell-based application in vivo, magnetic resonance imaging (MRI) of cells labeled with iron oxide particles is a common method. It is the aim of the present study [...] Read more.
Adipose tissue-derived stromal cells (ASCs) represent a capable source for cell-based therapeutic approaches. For monitoring a cell-based application in vivo, magnetic resonance imaging (MRI) of cells labeled with iron oxide particles is a common method. It is the aim of the present study to analyze potential DNA damage, cytotoxicity and impairment of functional properties of human (h)ASCs after labeling with citrate-coated very small superparamagnetic iron oxide particles (VSOPs). Cytotoxic as well as genotoxic effects of the labeling procedure were measured in labeled and unlabeled hASCs using the MTT assay, comet assay and chromosomal aberration test. Trilineage differentiation was performed to evaluate an impairment of the differentiation potential due to the particles. Proliferation as well as migration capability were analyzed after the labeling procedure. Furthermore, the labeling of the hASCs was confirmed by Prussian blue staining, transmission electron microscopy (TEM) and high-resolution MRI. Below the concentration of 0.6 mM, which was used for the procedure, no evidence of genotoxic effects was found. At 0.6 mM, 1 mM as well as 1.5 mM, an increase in the number of chromosomal aberrations was determined. Cytotoxic effects were not observed at any concentration. Proliferation, migration capability and differentiation potential were also not affected by the procedure. Labeling with VSOPs is a useful labeling method for hASCs that does not affect their proliferation, migration and differentiation potential. Despite the absence of cytotoxicity, however, indications of genotoxic effects have been demonstrated. Full article
(This article belongs to the Special Issue Functional Nanomaterials for Biomedical Applications)
►▼ Show Figures

Figure 1

Review

Jump to: Research

19 pages, 1251 KiB  
Review
Nanosensors for Visual Detection of Glucose in Biofluids: Are We Ready for Instrument-Free Home-Testing?
by Luca Boselli, Tania Pomili, Paolo Donati and Pier P. Pompa
Materials 2021, 14(8), 1978; https://doi.org/10.3390/ma14081978 - 15 Apr 2021
Cited by 16 | Viewed by 4243
Abstract
Making frequent large-scale screenings for several diseases economically affordable would represent a real breakthrough in healthcare. One of the most promising routes to pursue such an objective is developing rapid, non-invasive, and cost-effective home-testing devices. As a first step toward a diagnostic revolution, [...] Read more.
Making frequent large-scale screenings for several diseases economically affordable would represent a real breakthrough in healthcare. One of the most promising routes to pursue such an objective is developing rapid, non-invasive, and cost-effective home-testing devices. As a first step toward a diagnostic revolution, glycemia self-monitoring represents a solid base to start exploring new diagnostic strategies. Glucose self-monitoring is improving people’s life quality in recent years; however, current approaches still present vast room for improvement. In most cases, they still involve invasive sampling processes (i.e., finger-prick), quite discomforting for frequent measurements, or implantable devices which are costly and commonly dedicated to selected chronic patients, thus precluding large-scale monitoring. Thanks to their unique physicochemical properties, nanoparticles hold great promises for the development of rapid colorimetric devices. Here, we overview and analyze the main instrument-free nanosensing strategies reported so far for glucose detection, highlighting their advantages/disadvantages in view of their implementation as cost-effective rapid home-testing devices, including the potential use of alternative non-invasive biofluids as samples sources. Full article
(This article belongs to the Special Issue Functional Nanomaterials for Biomedical Applications)
►▼ Show Figures

Figure 1

71 pages, 1103 KiB  
Review
A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment
by Rayssa de Sousa Victor, Adillys Marcelo da Cunha Santos, Bianca Viana de Sousa, Gelmires de Araújo Neves, Lisiane Navarro de Lima Santana and Romualdo Rodrigues Menezes
Materials 2020, 13(21), 4995; https://doi.org/10.3390/ma13214995 - 06 Nov 2020
Cited by 79 | Viewed by 5588
Abstract
Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the [...] Read more.
Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the presence of free protonable amino groups along the chitosan backbone, which also gives it solubility in acidic conditions. Moreover, this biopolymer can also be physically modified, thereby presenting a variety of forms to be developed. Consequently, this polysaccharide is used in various fields, such as tissue engineering, drug delivery systems, and cancer treatment. In this sense, this review aims to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications. We present the most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity, and the possibility of adding several therapeutic metal ions as a strategy to improve the therapeutic potential of this polymer. Full article
(This article belongs to the Special Issue Functional Nanomaterials for Biomedical Applications)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop