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Lipid and Detergent Related Materials for Drug Delivery
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Lipid and Detergent Related Materials for Drug Delivery

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 August 2022) | Viewed by 22050

Special Issue Editor

Dr. Aleksander Czogalla

E-Mail Website
Guest Editor
Department of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, 14a F. Joliot-Curie St., 50-383 Wrocław, Poland
Interests: lipid membranes; signaling lipids; lipid rafts; protein-lipid interactions; protein-protein interactions; liposomes; lipid vesicles; fluorescence microscopy; synthetic biology; drug delivery

Special Issue Information

Dear Colleagues,

Modern drug development is facing a common problem of low bioavailability of active ingredients, mostly as a consequence of their limited water solubility. Moreover, rapid clearance and/or high toxicity are further factors that stimulate development of delivery carriers that would guarantee efficient therapy. Drug carriers may not only increase bioavailability and effectiveness but also improve the selectivity and safety of drug administration. Among various approaches used to achieve the ultimate goal, those based on lipid and detergent-related materials seem to be most promising. Our intention is to launch a Special Issue which will be composed of full papers, communications, and reviews that emphasize the emerging trends in the field. The articles in this Special Issue will cover a broad array of topics, ranging from innovative compounds and formulations that can be used as drug carriers to the assembly of various nanoparticles of unique properties and composition, evaluation of their efficiency and toxicity, etc. Therefore, I am pleased to announce that contributions from all researchers working on any aspect of lipid or detergent-based materials for drug delivery are welcome.

Adj. Prof. Aleksander Czogalla
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drug delivery
  • Lipids
  • Detergents
  • Nanoparticles
  • Emulsions
  • Colloids
  • Liposomes
  • Micelles
  • Drug carrier
  • Cancer therapy

Published Papers (6 papers)

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Research

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14 pages, 1750 KiB  
Article
Diptool—A Novel Numerical Tool for Membrane Interactions Analysis, Applying to Antimicrobial Detergents and Drug Delivery Aids
by Mateusz Rzycki, Sebastian Kraszewski and Marta Gładysiewicz-Kudrawiec
Materials 2021, 14(21), 6455; https://doi.org/10.3390/ma14216455 - 27 Oct 2021
Cited by 2 | Viewed by 1839
Abstract
The widespread problem of resistance development in bacteria has become a critical issue for modern medicine. To limit that phenomenon, many compounds have been extensively studied. Among them were derivatives of available drugs, but also alternative novel detergents such as Gemini surfactants. Over [...] Read more.
The widespread problem of resistance development in bacteria has become a critical issue for modern medicine. To limit that phenomenon, many compounds have been extensively studied. Among them were derivatives of available drugs, but also alternative novel detergents such as Gemini surfactants. Over the last decade, they have been massively synthesized and studied to obtain the most effective antimicrobial agents, as well as the most selective aids for nanoparticles drug delivery. Various protocols and distinct bacterial strains used in Minimal Inhibitory Concentration experimental studies prevented performance benchmarking of different surfactant classes over these last years. Motivated by this limitation, we designed a theoretical methodology implemented in custom fast screening software to assess the surfactant activity on model lipid membranes. Experimentally based QSAR (quantitative structure-activity relationship) prediction delivered a set of parameters underlying the Diptool software engine for high-throughput agent-membrane interactions analysis. We validated our software by comparing score energy profiles with Gibbs free energy from the Adaptive Biasing Force approach on octenidine and chlorhexidine, popular antimicrobials. Results from Diptool can reflect the molecule behavior in the lipid membrane and correctly predict free energy of translocation much faster than classic molecular dynamics. This opens a new venue for searching novel classes of detergents with sharp biologic activity. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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20 pages, 3500 KiB  
Article
The Elucidation of the Molecular Mechanism of the Extrusion Process
by Joanna Doskocz, Paulina Dałek, Magdalena Przybyło, Barbara Trzebicka, Aleksander Foryś, Anastasiia Kobyliukh, Aleš Iglič and Marek Langner
Materials 2021, 14(15), 4278; https://doi.org/10.3390/ma14154278 - 30 Jul 2021
Cited by 7 | Viewed by 2595
Abstract
Extrusion is a popular method for producing homogenous population of unilamellar liposomes. The technique relies on forcing a lipid suspension through cylindrical pores in a polycarbonate membrane. The quantification of the extrusion and/or recalibration processes make possible the acquisition of experimental data, which [...] Read more.
Extrusion is a popular method for producing homogenous population of unilamellar liposomes. The technique relies on forcing a lipid suspension through cylindrical pores in a polycarbonate membrane. The quantification of the extrusion and/or recalibration processes make possible the acquisition of experimental data, which can be correlated with the mechanical properties of the lipid bilayer. In this work, the force needed for the extrusion process was correlated with the mechanical properties of a lipid bilayer derived from other experiments. Measurements were performed using a home-made dedicated device capable of maintaining a stable volumetric flux of a liposome suspension through well-defined pores and to continuously measure the extrusion force. Based on the obtained results, the correlation between the lipid bilayer bending rigidity and extrusion force was derived. Specifically, it was found that the bending rigidity of liposomes formed from well-defined lipid mixtures agrees with data obtained by others using flicker-noise spectroscopy or micromanipulation. The other issue addressed in the presented studies was the identification of molecular mechanisms leading to the formation of unilamellar vesicles in the extrusion process. Finally, it was demonstrated that during the extrusion, lipids are not exchanged between vesicles, i.e., vesicles can divide but no membrane fusion or lipid exchange between bilayers was detected. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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Review

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28 pages, 19065 KiB  
Review
Synthesis and Potential Applications of Lipid Nanoparticles in Medicine
by Ewelina Musielak, Agnieszka Feliczak-Guzik and Izabela Nowak
Materials 2022, 15(2), 682; https://doi.org/10.3390/ma15020682 - 17 Jan 2022
Cited by 50 | Viewed by 5993
Abstract
Currently, carriers of active ingredients in the form of particles of a size measured in nanometers are the focus of interest of research centers worldwide. So far, submicrometer emulsions, liposomes, as well as microspheres, and nanospheres made of biodegradable polymers have been used [...] Read more.
Currently, carriers of active ingredients in the form of particles of a size measured in nanometers are the focus of interest of research centers worldwide. So far, submicrometer emulsions, liposomes, as well as microspheres, and nanospheres made of biodegradable polymers have been used in medicine. Recent studies show particular interest in nanoparticles based on lipids, and at the present time, are even referred to as the “era of lipid carriers”. With the passage of time, lipid nanoparticles of the so-called first and second generation, SLN (Solid Lipid Nanoparticles) and nanostructured lipid carriers and NLC (Nanostructured Lipid Carriers), respectively, turned out to be an alternative for all imperfections of earlier carriers. These carriers are characterized by a number of beneficial functional properties, including, among others, structure based on lipids well tolerated by the human body, high stability, and ability to carry hydro- and lipophilic compounds. Additionally, these carriers can enhance the distribution of the drug in the target organ and alter the pharmacokinetic properties of the drug carriers to enhance the medical effect and minimize adverse side effects. This work is focused on the current review of the state-of-the-art related to the synthesis and applications of popular nanoparticles in medicine, with a focus on their use, e.g., in COVID-19 vaccines. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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18 pages, 1089 KiB  
Review
Polyethyleneimine-Based Lipopolyplexes as Carriers in Anticancer Gene Therapies
by Julia Jerzykiewicz and Aleksander Czogalla
Materials 2022, 15(1), 179; https://doi.org/10.3390/ma15010179 - 27 Dec 2021
Cited by 10 | Viewed by 3412
Abstract
Recent years have witnessed rapidly growing interest in application of gene therapies for cancer treatment. However, this strategy requires nucleic acid carriers that are both effective and safe. In this context, non-viral vectors have advantages over their viral counterparts. In particular, lipopolyplexes—nanocomplexes consisting [...] Read more.
Recent years have witnessed rapidly growing interest in application of gene therapies for cancer treatment. However, this strategy requires nucleic acid carriers that are both effective and safe. In this context, non-viral vectors have advantages over their viral counterparts. In particular, lipopolyplexes—nanocomplexes consisting of nucleic acids condensed with polyvalent molecules and enclosed in lipid vesicles—currently offer great promise. In this article, we briefly review the major aspects of developing such non-viral vectors based on polyethyleneimine and outline their properties in light of anticancer therapeutic strategies. Finally, examples of current in vivo studies involving such lipopolyplexes and possibilities for their future development are presented. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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17 pages, 2078 KiB  
Review
Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants
by Ana R. Fernandes, Elena Sanchez-Lopez, Tiago dos Santos, Maria L. Garcia, Amelia M. Silva and Eliana B. Souto
Materials 2021, 14(24), 7541; https://doi.org/10.3390/ma14247541 - 08 Dec 2021
Cited by 20 | Viewed by 3186
Abstract
The eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto [...] Read more.
The eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailability of drugs for the treatment of eye diseases, in particular those affecting the posterior segment. In this review, we address the main factors that govern the development of a suitable nanoemulsion formulation for eye administration to increase the patient’s compliance to the treatment. Appropriate lipid composition and type of surfactants (with a special emphasis on cationic compounds) are discussed, together with manufacturing techniques and characterization methods that are instrumental for the development of appropriate ophthalmic nanoemulsions. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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23 pages, 3415 KiB  
Review
Lipid-Based Drug Delivery Systems in Regenerative Medicine
by Nina Filipczak, Satya Siva Kishan Yalamarty, Xiang Li, Muhammad Muzamil Khan, Farzana Parveen and Vladimir Torchilin
Materials 2021, 14(18), 5371; https://doi.org/10.3390/ma14185371 - 17 Sep 2021
Cited by 16 | Viewed by 3954
Abstract
The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its [...] Read more.
The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration. Full article
(This article belongs to the Special Issue Lipid and Detergent Related Materials for Drug Delivery)
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