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Functional Materials/Surfaces in Biomedical Applications
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Functional Materials/Surfaces in Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 25612

Special Issue Editors

Prof. Dr. Rumen Krastev

E-Mail Website
Guest Editor
Faculty of Applied Chemistry, Reutlingen University, Alteburgstraße 150, Reutlingen, Germany
Interests: surface modification; biological systems; pro-/anti-adhesive surfaces; passive/(bio)active surfaces
Dr. Xin Xiong

E-Mail Website
Guest Editor
NMI Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany
Interests: collagen; biomaterials; coating; antibacterial surfaces; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Functional materials have been developed for numerous fileds, including energy, automobile, space technology, and life sciences, and can be found in many applications such as coating, particles, and block materials. In biomedicine, the need for naturally derived and/or naturally inspired materials with defined medical functionalities is growing rapidly. The functional materials are designed being applied to replace tissue functions, to improve the biocompatibility of medical devices, and to reduce the foreign body reactions especially by implantable devices, to avoid undesirable interactions in the human body, to avoid contamination, and to fulfill certain therapeutic tasks such as drug delivery. These applications require not only newly developed materials but also a thoroughly established assessment route toward the potential clinical evaluation and approval by the authorities.

This Special Issue intends to publish articles on novel functional materials, fucntional surfaces, material engineering, design, characterization, and biological/clinical evaluations.

Themes of interest are:

  • Functional materials and fucntionalization of surfaces/materials;
  • Physical, chemical, and biological characterizations;
  • Cell/tissue responses and their controlling;
  • Controlling of biological systems such as human cells and bacteria.

Prof. Dr. Rumen Krastev
Dr. Xin Xiong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional materials
  • characterization
  • surface functionalization
  • biomedical application
  • cellular/tissue responses
  • biological systems

Published Papers (12 papers)

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Research

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13 pages, 1567 KiB  
Article
Impact of Natural-Based Viscosity Modifiers of Inhalation Drugs on the Dynamic Surface Properties of the Pulmonary Surfactant
by Katarzyna Dobrowolska, Małgorzata Miros and Tomasz R. Sosnowski
Materials 2023, 16(5), 1975; https://doi.org/10.3390/ma16051975 - 28 Feb 2023
Cited by 1 | Viewed by 1025
Abstract
The effectiveness of inhalation therapy depends on aerosol size distribution, which determines the penetration and regional deposition of drug in the lungs. As the size of droplets inhaled from medical nebulizers varies depending on the physicochemical properties of the nebulized liquid, it can [...] Read more.
The effectiveness of inhalation therapy depends on aerosol size distribution, which determines the penetration and regional deposition of drug in the lungs. As the size of droplets inhaled from medical nebulizers varies depending on the physicochemical properties of the nebulized liquid, it can be adjusted by adding some compounds as viscosity modifiers (VMs) of a liquid drug. Natural polysaccharides have been recently proposed for this purpose and while they are biocompatible and generally recognized as safe (GRAS), their direct influence of the pulmonary structures is unknown. This work studied the direct influence of three natural VMs (sodium hyaluronate, xanthan gum, and agar) on the surface activity of the pulmonary surfactant (PS) measured in vitro using the oscillating drop method. The results allowed for comparing the variations of the dynamic surface tension during breathing-like oscillations of the gas/liquid interface with the PS, and the viscoelastic response of this system, as reflected by the hysteresis of the surface tension. The analysis was done using quantitative parameters, i.e., stability index (SI), normalized hysteresis area (HAn), and loss angle (φ), depending on the oscillation frequency (f). It was also found that, typically, SI is in the range of 0.15–0.3 and increases nonlinearly with f, while φ slightly decreases. The effect of NaCl ions on the interfacial properties of PS was noted, which was usually positive for the size of hysteresis with an HAn value up to 2.5 mN/m. All VMs in general were shown to have only a minor effect on the dynamic interfacial properties of PS, suggesting the potential safety of the tested compounds as functional additives in medical nebulization. The results also demonstrated relationships between the parameters typically used in the analysis of PS dynamics (i.e., HAn and SI) and dilatational rheological properties of the interface, allowing for easier interpretation of such data. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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13 pages, 1233 KiB  
Communication
CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems
by Yan Yik Lim, Azizi Miskon and Ahmad Mujahid Ahmad Zaidi
Materials 2022, 15(21), 7672; https://doi.org/10.3390/ma15217672 - 01 Nov 2022
Cited by 11 | Viewed by 1475
Abstract
This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This [...] Read more.
This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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17 pages, 6297 KiB  
Article
Structural Strength Analyses for Low Brass Filler Biomaterial with Anti-Trauma Effects in Articular Cartilage Scaffold Design
by Yan Yik Lim, Azizi Miskon and Ahmad Mujahid Ahmad Zaidi
Materials 2022, 15(13), 4446; https://doi.org/10.3390/ma15134446 - 24 Jun 2022
Cited by 14 | Viewed by 1572
Abstract
The existing harder biomaterial does not protect the tissue cells with blunt-force trauma effects, making it a poor choice for the articular cartilage scaffold design. Despite the traditional mechanical strengths, this study aims to discover alternative structural strengths for the scaffold supports. The [...] Read more.
The existing harder biomaterial does not protect the tissue cells with blunt-force trauma effects, making it a poor choice for the articular cartilage scaffold design. Despite the traditional mechanical strengths, this study aims to discover alternative structural strengths for the scaffold supports. The metallic filler polymer reinforced method was used to fabricate the test specimen, either low brass (Cu80Zn20) or titanium dioxide filler, with composition weight percentages (wt.%) of 0, 2, 5, 15, and 30 in polyester urethane adhesive. The specimens were investigated for tensile, flexural, field emission scanning electron microscopy (FESEM), and X-ray diffraction (XRD) tests. The tensile and flexural test results increased with wt.%, but there were higher values for low brass filler specimens. The tensile strength curves were extended to discover an additional tensile strength occurring before 83% wt.%. The higher flexural stress was because of the Cu solvent and Zn solute substituting each other randomly. The FESEM micrograph showed a cubo-octahedron shaped structure that was similar to the AuCu3 structure class. The XRD pattern showed two prominent peaks of 2θ of 42.6° (110) and 49.7° (200) with d-spacings of 1.138 Å and 1.010 Å, respectively, that indicated the typical face-centred cubic superlattice structure with Cu and Zn atoms. Compared to the copper, zinc, and cart brass, the low brass indicated these superlattice structures had ordered–disordered transitional states. As a result, this additional strength was created by the superlattice structure and ordered–disordered transitional states. This innovative strength has the potential to develop into an anti-trauma biomaterial for osteoarthritic patients. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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15 pages, 8316 KiB  
Article
The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes
by Manuel Abels, Said Alkildani, Annica Pröhl, Xin Xiong, Rumen Krastev, Tadas Korzinskas, Sanja Stojanovic, Ole Jung, Stevo Najman and Mike Barbeck
Materials 2021, 14(23), 7372; https://doi.org/10.3390/ma14237372 - 01 Dec 2021
Cited by 11 | Viewed by 1693
Abstract
The physicochemical properties of synthetically produced bone substitute materials (BSM) have a major impact on biocompatibility. This affects bony tissue integration, osteoconduction, as well as the degradation pattern and the correlated inflammatory tissue responses including macrophages and multinucleated giant cells (MNGCs). Thus, influencing [...] Read more.
The physicochemical properties of synthetically produced bone substitute materials (BSM) have a major impact on biocompatibility. This affects bony tissue integration, osteoconduction, as well as the degradation pattern and the correlated inflammatory tissue responses including macrophages and multinucleated giant cells (MNGCs). Thus, influencing factors such as size, special surface morphologies, porosity, and interconnectivity have been the subject of extensive research. In the present publication, the influence of the granule size of three identically manufactured bone substitute granules based on the technology of hydroxyapatite (HA)-forming calcium phosphate cements were investigated, which includes the inflammatory response in the surrounding tissue and especially the induction of MNGCs (as a parameter of the material degradation). For the in vivo study, granules of three different size ranges (small = 0.355–0.5 mm; medium = 0.5–1 mm; big = 1–2 mm) were implanted in the subcutaneous connective tissue of 45 male BALB/c mice. At 10, 30, and 60 days post implantationem, the materials were explanted and histologically processed. The defect areas were initially examined histopathologically. Furthermore, pro- and anti-inflammatory macrophages were quantified histomorphometrically after their immunohistochemical detection. The number of MNGCs was quantified as well using a histomorphometrical approach. The results showed a granule size-dependent integration behavior. The surrounding granulation tissue has passivated in the groups of the two bigger granules at 60 days post implantationem including a fibrotic encapsulation, while a granulation tissue was still present in the group of the small granules indicating an ongoing cell-based degradation process. The histomorphometrical analysis showed that the number of proinflammatory macrophages was significantly increased in the small granules at 60 days post implantationem. Similarly, a significant increase of MNGCs was detected in this group at 30 and 60 days post implantationem. Based on these data, it can be concluded that the integration and/or degradation behavior of synthetic bone substitutes can be influenced by granule size. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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20 pages, 7117 KiB  
Article
The Analysis of Polyethylene Hip Joint Endoprostheses Strength Parameters Changes after Use inside the Human Body
by Arkadiusz Szarek, Przemysław Postawa, Tomasz Stachowiak, Piotr Paszta, Joanna Redutko, Katarzyna Mordal, Aleksandra Kalwik, Justyna Łukomska-Szarek, Marek Gzik, Kamil Joszko, Dariusz Rydz, Małgorzata Łągiewka and Bożena Gzik-Zroska
Materials 2021, 14(22), 7091; https://doi.org/10.3390/ma14227091 - 22 Nov 2021
Cited by 3 | Viewed by 1457
Abstract
The influence of dynamic loads resulting from human motor activity and electrocorrosion inside the human body on the strength parameters of artificial joint elements has not yet been investigated. Hip joint arthroplasty is the most common surgical procedure in the world that allows [...] Read more.
The influence of dynamic loads resulting from human motor activity and electrocorrosion inside the human body on the strength parameters of artificial joint elements has not yet been investigated. Hip joint arthroplasty is the most common surgical procedure in the world that allows doctors to remove pain and restore motor skills in people with severe hip diseases, after accidents, and in the elderly. Based on the reports, this article assesses changes in the number of implanted endoprostheses in the years 2005–2019 and determines the trends and estimated changes in the number of implanted hip prostheses in the following decades. The study assesses changes in selected strength parameters of UHMW-PE polyethylene inserts of hip joint endoprostheses during their use in the human body. The research was carried out on appropriately collected samples from UHMW-PE cups removed from the human body with a known history and lifetime from 4 to 10 years. Patients’ body weight ranged from 735 [N] to 820 [N], and the declared physical activity was similar in the entire research group. As part of the research, the values of changes in dynamic modules and the mechanical loss coefficient were determined in relation to the share of the crystalline and amorphous phases of artificial UHMW-PE cups, removed from the human body after different periods of exploitation under similar operating conditions. The analysis of selected strength parameters was performed at a temperature of 40 °C, which corresponds to the working conditions inside the human body. On the basis of numerical studies, the influence of changes in material parameters on the deformation of the artificial acetabulum during the patient’s motor activity, which is one of the causes of fatigue destruction, was determined. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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11 pages, 2373 KiB  
Article
Preparation of Cationic Amphiphilic Nanoparticles with Modified Chitosan Derivatives for Doxorubicin Delivery
by Xiudong Liu, Huofei Zhou, Weiting Yu, Xin Xiong, Rumen Krastev and Xiaojun Ma
Materials 2021, 14(22), 7010; https://doi.org/10.3390/ma14227010 - 19 Nov 2021
Cited by 7 | Viewed by 1523
Abstract
Polymeric micelle-like nanoparticles have demonstrated effectiveness for the delivery of some poorly soluble or hydrophobic anticancer drugs. In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was [...] Read more.
Polymeric micelle-like nanoparticles have demonstrated effectiveness for the delivery of some poorly soluble or hydrophobic anticancer drugs. In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was further modified with a cationic glycidyltrimethylammounium chloride (GTMAC) to form a novel soluble chitosan derivative (HT-CS-DCA). The cationic amphiphilic HT-CS-DCA was easily self-assembled to micelle-like nanoparticles about 200 nm with narrow size distribution (PDI 0.08–0.18). The zeta potential of nanoparticles was in the range of 14 to 24 mV, indicating higher positive charges. Then, doxorubicin (DOX), an anticancer drug with poor solubility, was entrapped into HT-CS-DCA nanoparticles. The DOX release test was performed in PBS (pH 7.4) at 37 °C, and the results showed that there was no significant burst release in the first two hours, and the cumulative release increased steadily and slowly in the following hours. HT-CS-DCA nanoparticles loaded with DOX could easily enter into MCF-7 cells, as observed by a confocal microscope. As a result, DOX-loaded HT-CS-DCA nanoparticles demonstrated a significant inhibition activity on MCF-7 growth without obvious cellular toxicity in comparison with blank nanoparticles. Therefore, the anticancer efficacy of these cationic HT-CS-DCA nanoparticles showed great promise for the delivery of DOX in cancer therapy. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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11 pages, 2847 KiB  
Article
Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties
by Yanru Ren, Xiaoyan Qin, Mike Barbeck, Yi Hou, Haijun Xu, Luo Liu and Chaoyong Liu
Materials 2021, 14(22), 6901; https://doi.org/10.3390/ma14226901 - 15 Nov 2021
Cited by 8 | Viewed by 2471
Abstract
Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired [...] Read more.
Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H2O2 catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs). Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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12 pages, 2616 KiB  
Article
Physicochemical Properties of Two Generations of MTA-Based Root Canal Sealers
by Sawsan Abu Zeid, Hadeel Yaseen Edrees, Abeer Abdulaziz Mokeem Saleh and Osama S. Alothmani
Materials 2021, 14(20), 5911; https://doi.org/10.3390/ma14205911 - 09 Oct 2021
Cited by 5 | Viewed by 1973
Abstract
This study evaluated the physicochemical properties and the effect of solubility on the surface morphology and composition of the root canal sealers MTA-Bioseal, MTA-Fillapex, and Adseal. Discs (n = 10) of freshly mixed sealer were prepared and then analyzed by Fourier transform [...] Read more.
This study evaluated the physicochemical properties and the effect of solubility on the surface morphology and composition of the root canal sealers MTA-Bioseal, MTA-Fillapex, and Adseal. Discs (n = 10) of freshly mixed sealer were prepared and then analyzed by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDX). The discs were immersed for 1, 7, 14, and 28 days in deionized water. The solubility %; pH change of the solution; and released calcium, phosphate, and silicon were measured for each period. The flowability and film thickness were also evaluated. Changes in the surface morphology and composition after 28 days of immersion were evaluated by SEM/EDX. The data were statistically analyzed by one-way ANOVA at p < 0.05. The FTIR and EDX results revealed similar compositions of MTA-Bioseal and MTA-Fillapex, but with different concentrations. The two MTA-based sealers had higher solution alkalinity (pH > 10) than Adseal (pH ≈ 8.5). MTA-Fillapex exhibited the highest solubility % and the largest calcium and silicon ion release. MTA-Bioseal had the highest phosphate ion release. After 28 days, the sealer surfaces showed large micropores, with larger pores in MTA-Fillapex. Adseal had an intermediate flowability but exhibited the greatest film thickness. Finally, the highest solubility and largest amount of silicon release was exhibited by MTA-Fillapex, which might predispose it to the development of large micropores, compromising the apical seal of obturation. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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19 pages, 4611 KiB  
Article
Synthesized Nanorods Hydroxyapatite by Microwave-Assisted Technology for In Vitro Osteoporotic Bone Regeneration through Wnt/β-Catenin Pathway
by Nadia Z. Shaban, Marwa Y. Kenawy, Nahla A. Taha, Mona M. Abd El-Latif and Doaa A. Ghareeb
Materials 2021, 14(19), 5823; https://doi.org/10.3390/ma14195823 - 05 Oct 2021
Cited by 10 | Viewed by 1898
Abstract
This research presents an optimal and inexpensive, without any additives, method for the synthesis and sintering of hydroxyapatite (HA) by microwave-assisted technology (MAT) furnace. The target sintering temperature of the furnace (1100 ℃) was held for one and two hours for conventional sintering. [...] Read more.
This research presents an optimal and inexpensive, without any additives, method for the synthesis and sintering of hydroxyapatite (HA) by microwave-assisted technology (MAT) furnace. The target sintering temperature of the furnace (1100 ℃) was held for one and two hours for conventional sintering. With regard to the microwave hybrid sintering, it was held at 100%MW for 20 and 30 min. FTIR, XRD, TGA, SEM/EDS, and TEM were assessed to determine HA phase composition, and structural as well as thermal decomposition behavior. The in vitro effects of sintered HA discs on cultured aged mice-isolated osteoblast cells and hydrocortisone-induced osteoclast cells were assessed by measuring ALP, osteocalcin, TRAP, calcium, and Alizarin red S staining. Moreover, their effects on cell differentiation (CD90 and CD 105 and PARR- ɣ) and death markers (GSK3b, MAPK, and β-catenin) were evaluated. The results demonstrate the production of ≈35 nm crystal-sized pure hydroxyapatite nanorod-like particles with a high degree of crystallinity and no impurities as required for biomedical application. HA increased osteogenesis (ALP, osteocalcin, and calcium) markers and decreased cell resorption markers. In addition, HA nanorods reversed the effect of cortisone on cell differentiation and death markers. In conclusion, microwave hybrid sintered HA is a potential nanomaterial for osteoporotic bone regeneration as HA reversed the cortisone adverse effect on osteoblast cell death through canonical and non-canonical pathways. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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12 pages, 4538 KiB  
Article
Direct Surface Modification of Polycaprolactone-Based Shape Memory Materials to Introduce Positive Charge Aiming to Enhance Cell Affinity
by Takafumi Zako, Shoko Matsushita, Toru Hoshi and Takao Aoyagi
Materials 2021, 14(19), 5797; https://doi.org/10.3390/ma14195797 - 03 Oct 2021
Cited by 3 | Viewed by 1502
Abstract
In this study, the introduction of a positive charge on the surface of a shape memory material was investigated to enhance cell affinity. To achieve this, the direct chemical modification of a material surface was proposed. Sheet-type, crosslinked poly(caprolactone-co-α-bromo-ɤ-butyrolactone) (poly(CL-co [...] Read more.
In this study, the introduction of a positive charge on the surface of a shape memory material was investigated to enhance cell affinity. To achieve this, the direct chemical modification of a material surface was proposed. Sheet-type, crosslinked poly(caprolactone-co-α-bromo-ɤ-butyrolactone) (poly(CL-co-BrBL)) were prepared, and the direct reaction of amino compounds with bromo groups was conducted on the material surface with a positive charge. Branched poly(CL-co-BrBL) was prepared, followed by the introduction of methacryloyl groups to each chain end. Using the branched macromonomers, stable and sheet-type materials were derived through UV-light irradiation. Then, the materials were soaked in an amino compound solution to react with the bromo groups under various conditions. Differential scanning calorimetry and surface analysis of the modified materials indicated that 10 vol% of N, N-dimethylethylenediamine in n-hexane and 1 h soaking time were optimal to maintain the inherent thermal properties. The achievement of increased luminance and a positive zeta potential proved that the direct modification method effectively introduced the positive charge only on the surface, thereby enhancing cell affinity. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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Review

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22 pages, 6153 KiB  
Review
Recent Advancements in the Fabrication of Functional Nanoporous Materials and Their Biomedical Applications
by Matthew Hadden, David Martinez-Martin, Ken-Tye Yong, Yogambha Ramaswamy and Gurvinder Singh
Materials 2022, 15(6), 2111; https://doi.org/10.3390/ma15062111 - 13 Mar 2022
Cited by 15 | Viewed by 5505
Abstract
Functional nanoporous materials are categorized as an important class of nanostructured materials because of their tunable porosity and pore geometry (size, shape, and distribution) and their unique chemical and physical properties as compared with other nanostructures and bulk counterparts. Progress in developing a [...] Read more.
Functional nanoporous materials are categorized as an important class of nanostructured materials because of their tunable porosity and pore geometry (size, shape, and distribution) and their unique chemical and physical properties as compared with other nanostructures and bulk counterparts. Progress in developing a broad spectrum of nanoporous materials has accelerated their use for extensive applications in catalysis, sensing, separation, and environmental, energy, and biomedical areas. The purpose of this review is to provide recent advances in synthesis strategies for designing ordered or hierarchical nanoporous materials of tunable porosity and complex architectures. Furthermore, we briefly highlight working principles, potential pitfalls, experimental challenges, and limitations associated with nanoporous material fabrication strategies. Finally, we give a forward look at how digitally controlled additive manufacturing may overcome existing obstacles to guide the design and development of next-generation nanoporous materials with predefined properties for industrial manufacturing and applications. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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9 pages, 275 KiB  
Review
Recent Advances in the Surface Functionalization of Nanomaterials for Antimicrobial Applications
by Shahin Shah Khan, Irfan Ullah, Sadeeq Ullah, Ruipeng An, Haijun Xu, Kaili Nie, Chaoyong Liu and Luo Liu
Materials 2021, 14(22), 6932; https://doi.org/10.3390/ma14226932 - 16 Nov 2021
Cited by 9 | Viewed by 2191
Abstract
Innovations in nanotechnology have had an immense impact on medicine, such as in drug delivery, tissue engineering, and medical devices that combat different pathogens. The pathogens that may cause biofilm-associated nosocomial diseases are multidrug-resistant (MDR) bacteria, such as Escherichia coli (E. coli [...] Read more.
Innovations in nanotechnology have had an immense impact on medicine, such as in drug delivery, tissue engineering, and medical devices that combat different pathogens. The pathogens that may cause biofilm-associated nosocomial diseases are multidrug-resistant (MDR) bacteria, such as Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus), including both Gram-positive and Gram-negative bacterial species. About 65–80% of infections are caused by biofilm-associated pathogens creating a move in the international community toward developing antimicrobial therapies to eliminate such pathogenic infections. Several nanomaterials (NMs) have been discovered and significantly employed in various antipathogenic therapies. These NMs have unique properties of singlet oxygen production, high absorption of near-infrared irradiation, and reasonable conversion of light to heat. In this review, functionalized NPs that combat different pathogenic infections are introduced. This review highlights NMs that combat infections caused by multidrug-resistant (MDR) and other pathogenic microorganisms. It also highlights the biomedical application of NPs with regard to antipathogenic activities. Full article
(This article belongs to the Special Issue Functional Materials/Surfaces in Biomedical Applications)
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