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Drug Delivery Systems Based on Mesoporous Silica

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Dear Colleagues,

Controlled drug delivery systems are an ideal strategy for human healthcare in which the drug is released at a constant rate and its concentration in the organism remains steady. After the first use of mesoporous silica as a carrier in drug delivery systems by María Vallet-Regí in 2001, they have attracted much attention in the biomedicine field because of their high specific surface area, ordered structure, large pore volume, modifiable surfaces, nontoxic nature, and good biocompatibility. The research on drug delivery systems based on mesoporous silica has grown enormously over the last two decades.

This Special Issue of Materials is focused on recent developments in and the application of different types of mesoporous silica for drug delivery. Suggested topics include the influence of surface modification on drug adsorption/release properties, targeted drug delivery systems, and “smart” systems—drug release or transport of nanoparticles caused by the influence of internal or external stimuli, such as pH, a magnetic field, photo-switchable systems driven by IR, UV, or VIS radiation, redox potential, and enzymes. Studies of computational methods and drug adsorption/release kinetics analyzed using different models (zero/first-order/Higuchi/Korsmeyer–Peppas/Hixson–Crowell/the three-parameter model) are also desirable.

We welcome any kind of manuscript dealing with drug delivery systems based on mesoporous silica.

Dr. Miroslav Almasi
Assoc. Prof. Virginie Hornebecq
Guest Editors

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Keywords

mesoporous silica
drug adsorption/release properties
surface modification
drug delivery systems
targeted drug delivery
stimuli-responsive “smart” systems
modeling and kinetic models

Published Papers (2 papers)

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Research

25 pages, 6001 KiB

Open AccessArticle

Thermosensitive Drug Delivery System SBA-15-PEI for Controlled Release of Nonsteroidal Anti-Inflammatory Drug Diclofenac Sodium Salt: A Comparative Study

by Lubos Zauska, Stefan Bova, Eva Benova, Jozef Bednarcik, Matej Balaz, Vladimir Zelenak, Virginie Hornebecq and Miroslav Almasi

Materials 2021, 14(8), 1880; https://doi.org/10.3390/ma14081880 - 09 Apr 2021

Cited by 24 | Viewed by 2451

Abstract

Mesoporous SBA-15 silica material was prepared by the sol–gel method and functionalized with thermosensitive polyethylenimine polymers with different molecular weight (g·mol⁻¹): 800 (SBA-15(C)-800), 1300 (SBA-15(C)-1300) and 2000 (SBA-15(C)-2000). The nonsteroidal anti-inflammatory drug (NSAID) diclofenac sodium was selected as a model drug and encapsulated into the pores of prepared supports. Materials were characterized by the combination of infrared spectroscopy (IR), atomic force microscopy (AFM), transmission electron microscopy (TEM), photon cross-correlation spectroscopy (PCCS), nitrogen adsorption/desorption analysis, thermogravimetry (TG), differential scanning calorimetry (DSC) and small-angle X-ray diffraction (SA-XRD) experiments. The drug release from prepared matrixes was realized in two model media differing in pH, namely small intestine environment/simulated body fluid (pH = 7.4) and simulated gastric fluid (pH = 2), and at different temperatures, namely normal body temperature (T = 37 °C) and inflammatory temperature (T = 42 °C). The process of drug loading into the pores of prepared materials from the diclofenac sodium salt solutions with different concentrations and subsequent quantitative determination of released drugs was analyzed by UV-VIS spectroscopy. Analysis of prepared SBA-15 materials modified with polyethylenimines in solution showed a high ability to store large amounts of the drug, up to 230 wt.%. Experimental results showed their high drug release into the solution at pH = 7.4 for both temperatures, which is related to the high solubility of diclofenac sodium in a slightly alkaline environment. At pH = 2, a difference in drug release rate was observed between both temperatures. Indeed, at a higher temperature, the release rates and the amount of released drug were 2–3 times higher than those observed at a lower temperature. Different kinetic models were used to fit the obtained drug release data to determine the drug release rate and its release mechanism. Moreover, the drug release properties of prepared compounds were compared to a commercially available medicament under the same experimental conditions. Full article

(This article belongs to the Special Issue Drug Delivery Systems Based on Mesoporous Silica)

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16 pages, 1061 KiB

Open AccessArticle

Development of Novel Oral Formulations of Disulfide Antioxidants Based on Porous Silica for Controlled Release of the Drugs

by Ekaterina S. Dolinina and Elena V. Parfenyuk

Materials 2021, 14(4), 963; https://doi.org/10.3390/ma14040963 - 18 Feb 2021

Cited by 1 | Viewed by 1758

Abstract

Powerful antioxidant α-lipoic acid (LA) exhibits limited therapeutic efficiency due to its pharmacokinetic properties. Therefore, the purpose of this work was to evaluate the ability of silica-based composites of LA as well as its amide (lipoamide, LM), as new oral drug formulations, to control their release and maintain their therapeutic concentration and antioxidant activity in the body over a long time. The composites synthesized at different sol–gel synthesis pH and based on silica matrixes with various surface chemistry were investigated. The release behavior of the composites in media mimicking pH of digestive fluids (pH 1.6, 6.8, and 7.4) was revealed. The effects of chemical structure of the antioxidants, synthesis pH, surface chemistry of the silica matrixes in the composites as well as the pH of release medium on kinetic parameters of the drug release and mechanisms of the process were discussed. The comparative analysis of the obtained data allowed the determination of the most promising composites. Using these composites, modeling of the release process of the antioxidants in accordance with transit conditions of the drugs in stomach, proximal, and distal parts of small intestine and colon was carried out. The composites exhibited the release close to the zero order kinetics and maintained the therapeutic concentration of the drugs and antioxidant effect in all parts of the intestine for up to 24 h. The obtained results showed that encapsulation of LA and LM in the silica matrixes is a promising way to improve their bioavailability and antioxidant activity. Full article

(This article belongs to the Special Issue Drug Delivery Systems Based on Mesoporous Silica)

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