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Bioengineering and Biotechnology of Clinical Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 March 2023) | Viewed by 1412

Special Issue Editor


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Guest Editor
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany
Interests: angiogenesis; bone regeneration; osseointegration; cancer biomarkers; oral cancer; tumor biology; dental implants

Special Issue Information

Dear Colleagues,

Clinical materials are widely used in medical and/or dental reconstructive procedures. The regenerative potential of these materials, including bone substitute materials, collagen matrices, polymers, composites, biological and biomimetics materials, as well as titanium alloys (such as implants), could be improved by bioengineering and biotechnology methods.

This Special Issue will address the most recent advances in tissue engineering and biomaterials science, including prevascularization, biologization, and fabrication technologies; additive manufacturing; surface modifications; antimicrobial properties; and models for implant manufacturing at the macro-, micro-, and nanoscale. Special emphasis will be paid to the analysis of the underlying cell-cell interactions, physicochemical signals, and surface-host interactions.

In this Special Issue of Materials, original papers and reviews, as well as pre-clinical and clinical studies, are warmly welcome.

Potential topics include, but are not limited to:

  • Bioactive modifications;
  • Immune response of the host;
  • 3D printing/additive manufacturing;
  • Homeostasis/wound healing;
  • Finite element/numerical analyses of physical surface modification.

Dr. Sebastian Blatt
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoinduction
  • angiogenesis
  • 3D printing
  • biologization
  • nanoscale

Published Papers (1 paper)

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Research

15 pages, 6922 KiB  
Article
Stent-Graft Fabrics Incorporating a Specific Corona Ready to Fenestrate
by Jing Lin, Xiaoning Guan, Mark Nutley, Jean M. Panneton, Ze Zhang, Robert Guidoin and Lu Wang
Materials 2023, 16(14), 4913; https://doi.org/10.3390/ma16144913 - 9 Jul 2023
Cited by 1 | Viewed by 1188
Abstract
In situ fenestration of endovascular stent-grafts has become a mainstream bailout technique to treat complex emergent aneurysms while maintaining native anatomical visceral and aortic arch blood supplies. Fabric tearing from creating the in situ fenestration using balloon angioplasty may extend beyond the intended [...] Read more.
In situ fenestration of endovascular stent-grafts has become a mainstream bailout technique to treat complex emergent aneurysms while maintaining native anatomical visceral and aortic arch blood supplies. Fabric tearing from creating the in situ fenestration using balloon angioplasty may extend beyond the intended diameter over time. Further tearing may result from the physiologic pulsatile motion at the branching site. A resultant endoleak at the fenestrated sites in stent-grafts could ultimately lead to re-pressurization of the aortic sac and, eventually, rupture. In an attempt to address this challenge, plain woven fabrics were designed. They hold a specific corona surrounding a square-shaped cluster with a plain weave fabric structure, a 2/2 twill, or a honeycomb. The corona was designed to stop potential further tearing of the fabric caused by the initial balloon angioplasty and stent or later post-implantation motion. The cluster within the corona was designed with relatively loose fabric structures (plain weave, 2/2 twill weave, and honeycomb) to facilitate the laser fenestration. Two commercial devices, Anaconda (Vascutek, Terumo Aortic) and Zenith TX2 (Cook), were selected as controls for comparison against this new design. All the specimens were characterized by morphology, thickness, and water permeability. The results demonstrated that all specimens with a low thickness and water permeability satisfied the requirements for a stent graft material that would be low profile and resistant to endoleaks. The in situ fenestrations were performed on all fabrics utilizing an Excimer laser followed by balloon angioplasty. The fabrics were further observed by light microscopy and scanning electron microscopy. The dimension of the fenestrated apertures was smaller than the balloon’s diameter. The tearing was effectively confined within the corona. The clinical acceptability of this concept deserves additional bench testing and animal experimentation. Full article
(This article belongs to the Special Issue Bioengineering and Biotechnology of Clinical Materials)
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