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Advances in Functional Hydrogel Biomaterials
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Advances in Functional Hydrogel Biomaterials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 April 2024) | Viewed by 5682

Special Issue Editor

Dr. Hyun Jong Lee

E-Mail Website
Guest Editor
Department of Chemical and Biological Engineering, Gachon University, Seongnam-si, Gyeonggi-do 13120, Korea
Interests: hydrogel; tissue engineering; drug delivery system; mechanobiology; stem cell fate control; hyaluronic acid hydrogel; click chemistry; electrospinning; three-dimensional cell culture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hydrogels consist of hydrophilic polymer networks that can hold large quantities of water. The high-water content of hydrogels provides a bio-friendly nature, and hydrogel biomaterials have been popular in the biomedical field. The three-dimensional network structure is linked through physical or chemical interaction. The types of crosslinking and component polymers can control the material properties, such as water content, mechanical strength, and degradation. Thus, versatile biomaterials can be designed in various ways according to their purpose.

Hydrogels are unique biomaterials that resemble the critical physiological characteristics of natural extracellular matrices. They have significant advantages in exploiting biomolecules, such as nucleic acids, proteins, and cells, and many studies have utilized the features. Still, novel hydrogel materials are synthesized, and various process technologies are used to fabricate functional hydrogels. Hydrogels are used as biomaterials for mechanobiology controlling cellular fate control. They are also used in the biomedical field, such as in tissue engineering, drug delivery, and biosensors, expanding into clinical applications. Researchers have been developing novel hydrogel materials, and advanced hydrogel materials will be widely used in the future.

We invite you to submit review articles, original papers, and communications for this Special Issue, “Advances in Functional Hydrogel Biomaterials.”

Dr. Hyun Jong Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthesis of novel hydrogel biomaterials and characterization
  • fabrication of novel hydrogel biomaterials with new processing technologies
  • applications of hydrogel biomaterials for tissue engineering, drug delivery, and biosensors
  • fate control of cells with hydrogel biomaterials
  • clinical application of hydrogel biomaterials

Published Papers (3 papers)

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Research

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22 pages, 24369 KiB  
Article
Investigation of Physicochemical Properties and Surface Morphology of Hydrogel Materials Incorporating Rosehip Extract
by Magdalena Kędzierska, Katarzyna Sala, Magdalena Bańkosz, Dominika Wroniak, Paweł Gajda, Piotr Potemski and Bożena Tyliszczak
Materials 2023, 16(17), 6037; https://doi.org/10.3390/ma16176037 - 02 Sep 2023
Viewed by 792
Abstract
Hydrogel materials are used in many fields of science and industry. They are of particular importance in biomedical applications. In this work, hydrogels were obtained that could act as a dressing for wounds, at the same time being a carrier of substances with [...] Read more.
Hydrogel materials are used in many fields of science and industry. They are of particular importance in biomedical applications. In this work, hydrogels were obtained that could act as a dressing for wounds, at the same time being a carrier of substances with antioxidant activity. The discussed materials were obtained in the field of UV radiation. The correlation between the amount of photoinitiator used and the physicochemical properties and surface morphology of the obtained materials was investigated. In addition, the hydrogels have been incorporated with wild rose extract, which is characterized by antioxidant and anti-inflammatory effects. The analysis of the sorption capacity confirmed that the obtained material is able to absorb significant amounts of incubation fluids, which, in terms of application, will enable the absorption of exudate from the wound. The highest stability of materials was noted for hydrogels obtained with the use of intermediate amounts of photoinitiator, i.e., 50 µL and 70 µL. In the case of using 20 µL or 100 µL, the photopolymerization process did not proceed properly and the obtained material was characterized by a lack of homogeneity and high brittleness. With the increase in the amount of photoinitiator, an increase in the surface roughness of hydrogel materials was confirmed. In turn, spectroscopic analysis ruled out the degradation of materials in incubation fluids, indicating the potential for their use in biomedical applications. Full article
(This article belongs to the Special Issue Advances in Functional Hydrogel Biomaterials)
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12 pages, 2681 KiB  
Article
Effective BMP-2 Release and Mineralization on a Graphene Oxide/Polyvinylpyrrolidone Hydrogel Forming Poly (ε-Caprolactone) Nanofibrous Scaffolds
by Jin-Oh Jeong, Sung-In Jeong, Youn-Mook Lim and Jong-Seok Park
Materials 2022, 15(23), 8642; https://doi.org/10.3390/ma15238642 - 04 Dec 2022
Cited by 2 | Viewed by 1545
Abstract
PCL nanofibrous scaffolds are widely used as bone scaffolds, and they can increase the efficiency of bone regeneration by loading drugs and/or growth factors onto them. However, to obtain a more effective bone regeneration effect, it is necessary to increase drug loading and [...] Read more.
PCL nanofibrous scaffolds are widely used as bone scaffolds, and they can increase the efficiency of bone regeneration by loading drugs and/or growth factors onto them. However, to obtain a more effective bone regeneration effect, it is necessary to increase drug loading and release efficiency. In this study, conductive hydrogel forming nanofibrous scaffolds were prepared to increase drug efficiency. GO has an excellent conductivity and biocompatibility, making it an efficient conductive polymer for bone differentiation. Electrospun PCL was immersed in a mixed solution of GO and PVP and then crosslinked using gamma-ray irradiation. It was confirmed that GO/PVP-PCL was successfully prepared through its characterization (morphology, thermal, chemical, electrical, and biological properties). In addition, drug-release efficiency was confirmed by electrical stimulation after loading the sample with BMP-2, a bone-regeneration growth factor. Compared to PCL, it was confirmed that GO/PVP-PCL has an approximately 20% improved drug-release efficiency and an excellent mineralization of the scaffolds using SBF. After culturing MG63 cells on GO/PVP-PCL, a high effect on osteodifferentiation was confirmed by ALP activity. Therefore, GO/PVP-PCL prepared by a gamma-ray-induced crosslinking reaction is expected to be used as biomaterial for bone-tissue engineering. Full article
(This article belongs to the Special Issue Advances in Functional Hydrogel Biomaterials)
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Review

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16 pages, 2349 KiB  
Review
Green Chemistry for Crosslinking Biopolymers: Recent Advances in Riboflavin-Mediated Photochemistry
by Yoon Bok Lee, Saebin Lim, Yerin Lee, Chan Ho Park and Hyun Jong Lee
Materials 2023, 16(3), 1218; https://doi.org/10.3390/ma16031218 - 31 Jan 2023
Cited by 7 | Viewed by 2802
Abstract
Riboflavin (RF), which is also known as vitamin B2, is a water-soluble vitamin. RF is a nontoxic and biocompatible natural substance. It absorbs light (at wavelengths of 380 and 450 nm) in the presence of oxygen to form reactive singlet oxygen (1 [...] Read more.
Riboflavin (RF), which is also known as vitamin B2, is a water-soluble vitamin. RF is a nontoxic and biocompatible natural substance. It absorbs light (at wavelengths of 380 and 450 nm) in the presence of oxygen to form reactive singlet oxygen (1O2). The generated singlet oxygen acts as a photoinitiator to induce the oxidation of biomolecules, such as amino acids, proteins, and nucleotides, or to initiate chemical reactions, such as the thiol-ene reaction and crosslinking of tyramine and furfuryl groups. In this review, we focus on the chemical mechanism and utilization of the photochemistry of RF, such as protein crosslinking and hydrogel formation. Currently, the crosslinking method using RF as a photoinitiator is actively employed in ophthalmic clinics. However, a significant broadening is expected in its range of applications, such as in tissue engineering and drug delivery. Full article
(This article belongs to the Special Issue Advances in Functional Hydrogel Biomaterials)
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