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Research on Bioactive Materials: Preparation, Characterization and Applications
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Research on Bioactive Materials: Preparation, Characterization and Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 2238

Special Issue Editors

Prof. Dr. Evandro Piva

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Guest Editor
Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Goncalves Chaves 457, Centro, Pelotas RS 96015-560, Brazil
Interests: dental materials; biomaterials; adhesion; nanostructures; biocompatible materials
Dr. Carlos Enrique Cuevas Suárez

E-Mail Website1 Website2
Guest Editor
Associate Professor, Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca, Mexico
Interests: dental composites; dental adhesives; bonding; dental biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in bioactive materials include the development of smart biomaterials that can respond to environmental stimuli, such as pH and temperature, allowing their properties to become accordingly adaptable. Bioactive materials are designed to mimic the natural extracellular matrix (ECM) found in tissues and organs, which can promote cell adhesion, proliferation, and differentiation. Biocompatible materials are placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth. Materials are fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.

This Special Issue aims to provide a platform for researchers to share their latest findings and developments in the field of bioactive materials.  The Special Issue welcomes original research articles, reviews, and communications that cover a wide range of topics related to bioactive materials, including (but not limited to) the following:

Synthesis, preparation, and characterization techniques of bioactive materials;

Applications of bioactive materials in biomedical fields, such as drug delivery, tissue engineering, regenerative engineering for human and veterinary medicine, and materials related to dentistry.

Prof. Dr. Evandro Piva
Dr. Carlos Enrique Cuevas Suárez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • extracellular matrix (ecm)
  • coated materials tissue engineering
  • ceramics
  • glasses
  • polymers
  • composites
  • smart biomaterials
  • drug delivery
  • dental implants
  • hydrogels
  • biomimetic materials.

Published Papers (2 papers)

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Research

14 pages, 7358 KiB  
Article
Applying the Alkali-Activation Method to Encapsulate Silicon Nitride Particles in a Bioactive Matrix for Augmented Strength and Bioactivity
by Guido Manuel Olvera de la Torre, Monika Tatarková, Zuzana Netriová, Martin Barlog, Luca Bertolla, Miroslav Hnatko and Gianmarco Taveri
Materials 2024, 17(2), 328; https://doi.org/10.3390/ma17020328 - 9 Jan 2024
Viewed by 942
Abstract
The development of bioactive ceramics still poses challenges in finding a good compromise between bioactivity and mechanical robustness. Moreover, a facile, low-cost and energy-saving synthesis technique is still needed. This study concerns the synthesis of a bioactive material by growing a bioactive Na-Ca-Mg-Si-based [...] Read more.
The development of bioactive ceramics still poses challenges in finding a good compromise between bioactivity and mechanical robustness. Moreover, a facile, low-cost and energy-saving synthesis technique is still needed. This study concerns the synthesis of a bioactive material by growing a bioactive Na-Ca-Mg-Si-based ceramic matrix produced using the alkali-activation method on silicon nitride (Si3N4) particles. This technique simultaneously forms the matrix precursor and functionalizes the Si3N4 particles’ surface. The optimal strength–bioactivity compromise was found for the composition containing 60 wt.% Si3N4 and 40 wt.% of the matrix exhibiting good compressive strength of up to 110 MPa and extensive precipitation of hydroxyapatite on the sample surface after 7 days of soaking in simulated body fluid. This innovative approach merging strong non-oxide binary ceramics with the versatile and low-cost alkali-activation method holds great expectations for the future in biomaterials. Full article
(This article belongs to the Special Issue Research on Bioactive Materials: Preparation, Characterization and Applications)
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13 pages, 4266 KiB  
Article
Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels
by Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya and Kunio Ishikawa
Materials 2023, 16(24), 7518; https://doi.org/10.3390/ma16247518 - 5 Dec 2023
Viewed by 860
Abstract
The internal structure of the scaffolds is a key factor for bone regeneration. In this study, we focused on the space dimensionality within the scaffold that may control cell migration and evaluated the effects on the size and orientation of blood vessels and [...] Read more.
The internal structure of the scaffolds is a key factor for bone regeneration. In this study, we focused on the space dimensionality within the scaffold that may control cell migration and evaluated the effects on the size and orientation of blood vessels and the amount of bone formation in the scaffold. The carbonate apatite scaffolds with intrascaffold space allowing one-dimensional (1D), two-dimensional (2D), or three-dimensional (3D) cell migration were fabricated by 3D printing. These scaffolds had the same space size, i.e., distances between the struts (~300 µm). The scaffolds were implanted into the medial condyle of rabbit femurs for four weeks. Both the size and orientation degree of the blood vessels formed in the scaffolds allowing 1D cell migration were 2.5- to 4.0-fold greater than those of the blood vessels formed in the scaffolds allowing 2D and 3D cell migration. Furthermore, the amount of bone formed in the scaffolds allowing 1D cell migration was 1.4-fold larger than that formed in the scaffolds allowing 2D and 3D cell migration. These are probably because the 1D space limited the direction of cell migration and prevented the branching of blood vessels, whereas 2D and 3D spaces provided the opportunity for random cell migration and blood vessel branching. Thus, scaffolds with 1D space are advantageous for inducing large and oriented blood vessels, resulting in a larger amount of bone formation. Full article
(This article belongs to the Special Issue Research on Bioactive Materials: Preparation, Characterization and Applications)
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