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Marine Drugs
Special Issues
Alginate-Based Biomaterials and Drug Delivery II
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Special Issue "Alginate-Based Biomaterials and Drug Delivery II"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Biomaterials of Marine Origin".

Deadline for manuscript submissions: 31 May 2023 | Viewed by 907

Special Issue Editors

Dr. Maila Castellano

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Guest Editor
Department of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy
Interests: sodium alginate; alginate–polymethacrylate hybrid hydrogels; functional polymeric materials; biomaterials; polymeric nanostructures; study of the physical properties; rheology and mechanical properties of polymers; surface modification and surface properties characterization of polymeric materials
Special Issues, Collections and Topics in MDPI journals
Dr. Andrea Dodero

E-Mail Website
Guest Editor
Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
Interests: biopolymers; biomedical applications; hydrogels; electrospinning; rheology; block copolymers; self-assembly; photonics; colloids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, alginate polysaccharide has assumed a major role as a promising and innovative biomaterial. It has been broadly explored in biomedical science and engineering owing to its biocompatibility, biodegradability, low immunogenicity, and gelling capabilities. Moreover, despite the most common use of this polysaccharide being related to food products, alginate-based materials show great potentialities for several biomedical purposes that can mimic many functions of the extracellular matrices of body tissues. For instance, recent advances in wound healing, drug delivery, and tissue engineering have been achieved by using alginate-based hydrogels, fibers, capsules, and particles.

Based on the success of the Special Issue “Alginate-Based Biomaterials and Drug Delivery” (https://www.mdpi.com/journal/marinedrugs/special_issues/alginate-based_biomaterials), as well as the critical relevance of this topic, we are pleased to announce the second edition of this Special Issue.

This Special Issue is devoted to both original research articles and reviews covering any aspect, from extraction to application, of alginate-based materials for biomedical and/or pharmaceutical purposes. As Guest Editors, we particularly encourage authors to submit their latest findings showing significant advances in this field.

Dr. Maila Castellano
Dr. Andrea Dodero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alginate
  • hydrogels
  • scaffolds
  • biomedical applications
  • drug delivery

Published Papers (2 papers)

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Research

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Article
Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase
by
Jun Jiang
,
Zhengqiang Jiang
,
Qiaojuan Yan
,
Susu Han
and
Shaoqing Yang
Mar. Drugs 2023, 21(4), 208; https://doi.org/10.3390/md21040208 - 27 Mar 2023
Viewed by 174
Abstract
Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was [...] Read more.
Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was high-level expressed in Pichia pastoris, with an enzyme yield of 560 U/mL and a protein content of 9.8 mg/mL by high-cell density fermentation. The recombinant enzyme was most active at 30 °C and pH 7.5, respectively. VfAly7 was a bifunctional alginate lyase with both poly-guluronate and poly-mannuronate hydrolysis activities. On the basis of VfAly7, a bioconversion strategy for the utilization of brown seaweed (Undaria pinnatifida) was developed. The obtained AOSs showed stronger prebiotic activity towards tested probiotics when compared to that of commercial fructooligosaccharides (FOSs), while the obtained protein hydrolysates displayed strong xanthine oxidase inhibitory activity with IC50 of 3.3 mg/mL. This study provided a novel alginate lyase tool as well as a biotransformation route for the utilization of seaweeds. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery II)
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Review

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Review
Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine
by
Nima Farshidfar
,
Siavash Iravani
and
Rajender S. Varma
Mar. Drugs 2023, 21(3), 189; https://doi.org/10.3390/md21030189 - 18 Mar 2023
Viewed by 546
Abstract
Today, with the salient advancements of modern and smart technologies related to tissue engineering and regenerative medicine (TE-RM), the use of sustainable and biodegradable materials with biocompatibility and cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer [...] Read more.
Today, with the salient advancements of modern and smart technologies related to tissue engineering and regenerative medicine (TE-RM), the use of sustainable and biodegradable materials with biocompatibility and cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed to develop a wide variety of composites for TE, drug delivery, wound healing, and cancer therapy. This sustainable and renewable biomaterial displays several fascinating properties such as high biocompatibility, low toxicity, cost-effectiveness, and mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation to the low solubility and high viscosity of high-molecular weight alginate, high density of intra- and inter-molecular hydrogen bonding, polyelectrolyte nature of the aqueous solution, and a lack of suitable organic solvents. Herein, TE-RM applications of alginate-based materials are deliberated, focusing on current trends, important challenges, and future prospects. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery II)
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