Alginate-Based Biomaterials and Drug Delivery 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Biomaterials of Marine Origin".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 9562

Special Issue Editors


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Guest Editor
Department of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy
Interests: sodium alginate; alginate–polymethacrylate hybrid hydrogels; functional polymeric materials; biomaterials; polymeric nanostructures; study of the physical properties; rheology and mechanical properties of polymers; surface modification and surface properties characterization of polymeric materials
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Guest Editor
Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland
Interests: biopolymers; biomedical applications; hydrogels; electrospinning; rheology; block copolymers; self-assembly; photonics; colloids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, alginate polysaccharide has assumed a major role as a promising and innovative biomaterial. It has been broadly explored in biomedical science and engineering owing to its biocompatibility, biodegradability, low immunogenicity, and gelling capabilities. Moreover, despite the most common use of this polysaccharide being related to food products, alginate-based materials show great potentialities for several biomedical purposes that can mimic many functions of the extracellular matrices of body tissues. For instance, recent advances in wound healing, drug delivery, and tissue engineering have been achieved by using alginate-based hydrogels, fibers, capsules, and particles.

Based on the success of the Special Issue “Alginate-Based Biomaterials and Drug Delivery” (https://www.mdpi.com/journal/marinedrugs/special_issues/alginate-based_biomaterials), as well as the critical relevance of this topic, we are pleased to announce the second edition of this Special Issue.

This Special Issue is devoted to both original research articles and reviews covering any aspect, from extraction to application, of alginate-based materials for biomedical and/or pharmaceutical purposes. As Guest Editors, we particularly encourage authors to submit their latest findings showing significant advances in this field.

Dr. Maila Castellano
Dr. Andrea Dodero
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alginate
  • hydrogels
  • scaffolds
  • biomedical applications
  • drug delivery

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Published Papers (4 papers)

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Research

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22 pages, 6213 KiB  
Article
Blood Coagulation Activities of Cotton–Alginate–Copper Composites
by Zdzisława Mrozińska, Michał Ponczek, Anna Kaczmarek, Maciej Boguń, Edyta Sulak and Marcin H. Kudzin
Mar. Drugs 2023, 21(12), 625; https://doi.org/10.3390/md21120625 - 30 Nov 2023
Viewed by 1440
Abstract
Alginate-based materials have gained significant attention in the medical industry due to their biochemical properties. In this article, we aimed to synthesize Cotton–Alginate–Copper Composite Materials (COT-Alg(−)Cu(2+)). The main purpose of this study was to assess the biochemical properties of [...] Read more.
Alginate-based materials have gained significant attention in the medical industry due to their biochemical properties. In this article, we aimed to synthesize Cotton–Alginate–Copper Composite Materials (COT-Alg(−)Cu(2+)). The main purpose of this study was to assess the biochemical properties of new composites in the area of blood plasma coagulation processes, including activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT). This study also involved in vitro antimicrobial activity evaluation of materials against representative colonies of Gram-positive and Gram-negative bacteria and antifungal susceptibility tests. The materials were prepared by immersing cotton fibers in an aqueous solution of sodium alginate, followed by ionic cross-linking of alginate chains within the fibers with Cu(II) ions to yield antimicrobial activity. The results showed that the obtained cotton–alginate–copper composites were promising materials to be used in biomedical applications, e.g., wound dressing. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery 2nd Edition)
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14 pages, 17763 KiB  
Article
Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase
by Jun Jiang, Zhengqiang Jiang, Qiaojuan Yan, Susu Han and Shaoqing Yang
Mar. Drugs 2023, 21(4), 208; https://doi.org/10.3390/md21040208 - 27 Mar 2023
Cited by 3 | Viewed by 1568
Abstract
Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was [...] Read more.
Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was high-level expressed in Pichia pastoris, with an enzyme yield of 560 U/mL and a protein content of 9.8 mg/mL by high-cell density fermentation. The recombinant enzyme was most active at 30 °C and pH 7.5, respectively. VfAly7 was a bifunctional alginate lyase with both poly-guluronate and poly-mannuronate hydrolysis activities. On the basis of VfAly7, a bioconversion strategy for the utilization of brown seaweed (Undaria pinnatifida) was developed. The obtained AOSs showed stronger prebiotic activity towards tested probiotics when compared to that of commercial fructooligosaccharides (FOSs), while the obtained protein hydrolysates displayed strong xanthine oxidase inhibitory activity with IC50 of 3.3 mg/mL. This study provided a novel alginate lyase tool as well as a biotransformation route for the utilization of seaweeds. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery 2nd Edition)
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Review

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16 pages, 4653 KiB  
Review
Alginate Core-Shell Capsules Production through Coextrusion Methods: Principles and Technologies
by Chanez Bennacef, Sylvie Desobry-Banon, Laurent Probst and Stéphane Desobry
Mar. Drugs 2023, 21(4), 235; https://doi.org/10.3390/md21040235 - 11 Apr 2023
Cited by 4 | Viewed by 2217
Abstract
This paper provides an overview of coextrusion methods for encapsulation. Encapsulation involves the coating or entrapment of a core material such as food ingredients, enzymes, cells, or bioactives. Encapsulation can help compounds add to other matrices, stabilize compounds during storage, or enable controlled [...] Read more.
This paper provides an overview of coextrusion methods for encapsulation. Encapsulation involves the coating or entrapment of a core material such as food ingredients, enzymes, cells, or bioactives. Encapsulation can help compounds add to other matrices, stabilize compounds during storage, or enable controlled delivery. This review explores the principal l coextrusion methods available that can be used to produce core-shell capsules through the use of coaxial nozzles. Four methods for encapsulation by coextrusion are examined in detail, including dripping, jet cutting, centrifugal, and electrohydrodynamic systems. The targeted capsule size determines the appropriate parameters for each method. Coextrusion technology is a promising encapsulation technique able to generate core-shell capsules in a controlled manner, which can be applied to cosmetic, food, pharmaceutical, agriculture, and textile industries. Coextrusion is an excellent way to preserve active molecules and present a significant economic interest. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery 2nd Edition)
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17 pages, 5929 KiB  
Review
Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine
by Nima Farshidfar, Siavash Iravani and Rajender S. Varma
Mar. Drugs 2023, 21(3), 189; https://doi.org/10.3390/md21030189 - 18 Mar 2023
Cited by 24 | Viewed by 3842
Abstract
Today, with the salient advancements of modern and smart technologies related to tissue engineering and regenerative medicine (TE-RM), the use of sustainable and biodegradable materials with biocompatibility and cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer [...] Read more.
Today, with the salient advancements of modern and smart technologies related to tissue engineering and regenerative medicine (TE-RM), the use of sustainable and biodegradable materials with biocompatibility and cost-effective advantages have been investigated more than before. Alginate as a naturally occurring anionic polymer can be obtained from brown seaweed to develop a wide variety of composites for TE, drug delivery, wound healing, and cancer therapy. This sustainable and renewable biomaterial displays several fascinating properties such as high biocompatibility, low toxicity, cost-effectiveness, and mild gelation by inserting divalent cations (e.g., Ca2+). In this context, challenges still exist in relation to the low solubility and high viscosity of high-molecular weight alginate, high density of intra- and inter-molecular hydrogen bonding, polyelectrolyte nature of the aqueous solution, and a lack of suitable organic solvents. Herein, TE-RM applications of alginate-based materials are deliberated, focusing on current trends, important challenges, and future prospects. Full article
(This article belongs to the Special Issue Alginate-Based Biomaterials and Drug Delivery 2nd Edition)
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