Advances in Zebrafish Genetics and Applications to Study the Cardiovascular System
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 13530
Special Issue Editors
Interests: stem cells; organoids; genetics; transcriptional adaptation; vascular biology; genome engineering; NGS; zebrafish
Special Issue Information
Dear Colleagues,
The Zebrafish (Danio rerio), represents a powerful vertebrate model to dissect the molecular pathways that drive organ formation. The high fecundity, external fertilization, ease of genetic manipulations, and transparency of its embryos and larvae make the zebrafish a powerful model to study organ development. Furthermore, it allows real-time imaging of developmental processes as well as developing pathologies.
In the last few decades and more recently with the advent of easy-to-use genetic engineering (CRISPR), next-generation sequencing (NGS) or single-cell RNA sequencing (scRNAseq) led to new insights in zebrafish genetics and the remarkable organotypic heterogeneity within the vascular system.
Furthermore, zebrafish has proven to be a great model to study genetic compensation, to employ large-scale mutagenesis and chemical genetics to dissect the molecular pathways of organ formation.
In this Special Issue, experts in the field will present their thoughts and views on the development of the cardiovascular system, including organotypic vasculatures, cell signaling, cell migration, angiocrine signaling, and cell interaction during cardiovascular development.
The topics may also include the zebrafish as a model for genetic compensation, large-scale genome editing, mutagenesis, and small-molecule screening.
We invite authors to submit original research articles, technical articles, and reviews covering the latest advances in the field.
We hope to include multi-disciplinary articles. Molecular, cellular, imaging, and bioinformatic approaches that focus on zebrafish as a model organism are all welcome.
Dr. Andrea Rossi
Prof. Dr. Christian Helker
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- zebrafish
- cardiovascular
- organotypic vasculature
- endothelial cells
- cardiomyocytes
- angiocrine signaling
- imaging
- heterogeneity
- genome editing
- next-generation sequencing
- screening
- transcriptional adaptation
