Drug Metabolism and Pharmacokinetics 2020

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 4130

Special Issue Editor


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Guest Editor
Department of Pharmacology & Clinical Pharmacology Laboratory, College of Medicine, Hanyang University, Seoul 04763, Republic of Korea
Interests: clinical trials; new drug development; drug/drug(food) interaction; pharmacokinetics
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Special Issue Information

Dear Colleagues,

Drug metabolism and pharmacokinetics covers all aspects of pre-clinical and clinical pharmacokinetics and pharmacodynamics, including drug disposition, metabolism, transport and interactions, therapeutic drug monitoring, CYP pharmacogenetics, PK/PD relationship, bioavailability and bioequivalence, drug–drug interactions, as well as clinical pharmacokinetics in older adults and children. Other topics such as clinical pharmacokinetics in certain disease states such as hepatic, renal, or thyroid disease; individual drug metabolism and pharmacokinetics; analytical method development and validation for drug metabolism and pharmacokinetic studies will also be included.

In the coming years, the onset of a revolutionary transformation of protocols and strategies for drug development is expected. Accurate information for pharmacokinetics and metabolism is one of the key factors to entering the complex arena of personalized medicine.

I would like to invite all of you, experts and beginners in the field of drug metabolism and pharmacokinetics, to contribute to this Special Issue with your ideas for accelerating the implementation of drug metabolism and pharmacokinetics research in drug development, as well as in clinical trials and clinical practice.

This Special Issue will publish original research articles, review articles, leading articles, and current opinion articles on the topics discussed above.

All manuscripts are subject to peer review by international experts.

Prof. Dr. Ju-Seop Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug disposition, metabolism, transport and interactions
  • therapeutic drug monitoring
  • CYP pharmacogenetics
  • PK/PD relationship
  • toxicokinetics and toxicodynamics
  • bioavailability and bioequivalence
  • drug-drug/ drug-food interactions
  • clinical pharmacokinetics in older adults and children
  • clinical pharmacokinetics in certain disease such as hepatic, renal or thyroid disease
  • individual drug metabolism and pharmacokinetics
  • analytical method development and validation for drug metabolism and pharmacokinetic studies

Published Papers (1 paper)

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Research

21 pages, 3825 KiB  
Article
Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method
by Seok-Ho Shin, Yuri Park, Min-Ho Park, Jin-Ju Byeon, Byeong ill Lee, Jangmi Choi and Young G. Shin
Life 2020, 10(7), 115; https://doi.org/10.3390/life10070115 - 19 Jul 2020
Cited by 5 | Viewed by 3601
Abstract
Neuro–inflammation is known to be one of the pathogenesis for the degenerative central nervous system (CNS) disease. Recently various approaches for the treatment of brain diseases by controlling neuro-inflammation in the brain have been introduced. In this respect, there is a continuous demand [...] Read more.
Neuro–inflammation is known to be one of the pathogenesis for the degenerative central nervous system (CNS) disease. Recently various approaches for the treatment of brain diseases by controlling neuro-inflammation in the brain have been introduced. In this respect, there is a continuous demand for CNS drugs, which could be safer and more effective. Omeprazole, a well-known proton-pump inhibitor (PPI) is generally prescribed for the treatment of peptic ulcer. In addition to the anti-gastric acid secretion mechanism, recent studies showed that omeprazole or PPIs would likely have anti-inflammation effects in vitro and in vivo, but their effects on anti-inflammation in brain are still unknown. In this study, omeprazole and its metabolites in a mouse’s brain after various routes of administration have been explored by stable isotope ratio-patterning liquid chromatography–mass spectrometric method. First, a simple liquid chromatography–mass spectrometric (LC–MS) method was established for the quantification of omeprazole in mouse plasma and brain. After that, omeprazole and its stable isotope (D3–omeprazole) were concomitantly administered through various routes to mice in order to identify novel metabolites characteristically observed in the mouse brain and were analyzed using a different LC–MS method with information-dependent analysis (IDA) scan. With this unique approach, several new metabolites of omeprazole were identified by the mass difference between omeprazole and stable isotope in both brain and plasma samples. A total of seventeen metabolites were observed, and the observed metabolites were different from each administration route or each matrix (brain or plasma). The brain pharmacokinetic profiles and brain-to-plasma partition coefficient (Kp) were also evaluated in a satellite study. Overall, these results provide better insights to understand the CNS-related biological effects of omeprazole and its metabolites in vivo. Full article
(This article belongs to the Special Issue Drug Metabolism and Pharmacokinetics 2020)
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