COVID-19 Convalescent Plasma for Immuno-Compromised Patients
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Epidemiology".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3308
Special Issue Editors
Interests: virology; emerging viruses; pandemics; viral evolution; hematology; immunogenetics; transplant immunology; transfusion medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
COVID-19 remains a life-threatening disease for severely immunocompromised patients, such as those with B-cell depletion, who do not develop protective immune responses even after multiple vaccine doses. These patients harbour chronic replication leading to significant intrahost variation and an inability to eradicate infection. Long-term treatment is required to prevent relapses. Among the currently authorized treatments, small-chemical antivirals are often contraindicated and have not been tested in immunocompromised patients. Many anti-spike monoclonal antibodies, which have been developed for over a year, are becoming ineffective against many novel SARS-CoV-2 variants of concern. Convalescent plasma is being increasingly recognized by both regulatory authorities and scientific societies as a robust therapeutic option for these patients.
In this Special Issue, we will include case series from different subsets of immunosuppressed patients (onco-haematological, rheumatological and solid organ transplant recipients) and review state-of-the-art techniques through international guidelines. Research that presents in vitro results detailing novel mechanisms of actions is also welcomed.
Dr. Daniele Focosi
Dr. Massimo Franchini
Guest Editors
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Keywords
- convalescent plasma
- COVID-19
- immunosuppression
