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Life
Special Issues
Organogenesis and Regeneration: From Basic Research to Medical Study
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Organogenesis and Regeneration: From Basic Research to Medical Study

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 879

Special Issue Editors

Prof. Dr. Long Zhao

E-Mail Website
Guest Editor
1. Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
2. College of Fisheries, Ocean University of China, Qingdao 266003, China
Interests: cardiac regeneration; heart development; organogenesis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ying Su

E-Mail Website
Guest Editor
1. Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
2. College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
Interests: animal development; signal transduction; hematopoiesis; pattern formation
Special Issues, Collections and Topics in MDPI journals
Dr. Juhui Qiu

E-Mail Website
Guest Editor
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, Chongqing University, Chongqing 400030, China
Interests: development; stress granule; biomechanics, cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
Dr. Yanchao Han

E-Mail Website
Guest Editor
Institute for Cardiovascular Science, Suzhou Medical College, Soochow University, Suzhou, China
Interests: cardiovascular development; heart regeneration; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

An organ is a multi-cellular organism whose formation requires cell–cell coordination to establish an accurate structure and function. Various cellular behaviors, such as cell division, cell differentiation, cell movement, cell–cell communication, pattern formation, etc., are involved in the process of organogenesis, and all must be tightly controlled. Numerous studies have explored the underlying mechanisms that govern the development and formation of different organs. However, we are still far from fully understanding these processes.

Regeneration is the capacity of adult animals to restore their lost/damaged tissues/organs after injury. This capacity largely differs among species, from whole-body regeneration in Hydra and planarians, body parts—such as the limbs and tail—regeneration in salamanders and Xenopus, to organ—such as the heart—regeneration in adult zebrafish and neonatal mice. Regeneration achieves faithful restoration of tissue/organs in structures and functions and requires precise control.

Organogenesis and regeneration may employ similar molecular and cellular mechanisms, but they also possess their own unique aspects. Deciphering the innate mechanisms of development and regeneration may help explore new therapeutic strategies to benefit human health.

This Life and Cells joint Special Issue “Organogenesis and Regeneration: From Basic Research to Medical Study” will include both original research articles and review articles about organogenesis and regeneration. Basic research to clinic reports are all welcome.

You may choose our Joint Special Issue in Cells.

Prof. Dr. Long Zhao
Prof. Dr. Ying Su
Dr. Juhui Qiu
Dr. Yanchao Han
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organogenesis
  • regeneration
  • development
  • proliferation
  • differentiation
  • blastema
  • signaling pathway

Published Papers (1 paper)

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Research

14 pages, 2723 KiB  
Article
Agaricus bisporus-Derived Glucosamine Hydrochloride Regulates VEGF through BMP Signaling to Promote Zebrafish Vascular Development and Impairment Repair
by Jiarui Sun, Qici Wu, Yuxin Wei, Wei Zhao, Haokun Lv, Wei Peng, Jiayi Zheng, Yixuan Chen, Zhengsen Wang, Yutian Pan and Yu Xue
Life 2023, 13(12), 2330; https://doi.org/10.3390/life13122330 - 12 Dec 2023
Viewed by 637
Abstract
Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, [...] Read more.
Glucosamine hydrochloride (GAH) is a natural component of glycoproteins present in almost all human tissues and participates in the construction of human tissues and cell membranes. GAH has a wide range of biological activities, particularly in anti-inflammatory and osteogenic damage repair. At present, little is known about how GAH functions in angiogenesis. To determine the role of GAH on vascular development and impairment repair, we used the inhibitors VRI, DMH1, and dorsomorphin (DM) to construct vascular-impaired models in Tg(kdrl: mCherry) transgenic zebrafish. We then treated with GAH and measured its repair effects on vascular impairment through fluorescence intensity, mRNA, and protein expression levels of vascular-specific markers. Our results indicate that GAH promotes vascular development and repairs impairment by regulating the vascular endothelial growth factor (VEGF) signaling pathway through modulation of bone morphogenetic protein (BMP) signaling. This study provides an experimental basis for the development of GAH as a drug to repair vascular diseases. Full article
(This article belongs to the Special Issue Organogenesis and Regeneration: From Basic Research to Medical Study)
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