Interstitial Lung Diseases: Clinical Features, Diagnosis, and Management

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1118

Special Issue Editors


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Guest Editor
Division of Pulmonology, Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik Hospital, Haeundae-gu, Haeundae-ro, Busan 48108, Republic of Korea
Interests: idiopathic pulmonary fibrosis; interstitial lung disease; prognosis; progressive pulmonary fibrosis; rare interstitial lung disease

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Guest Editor
Division of Pulmonary, Allergy and Critical Care Medicine, Inje University Busan Paik Hospital, Seoul, Republic of Korea
Interests: interstitial lung diseases; lung cancer; diagnosis; treatment

Special Issue Information

Dear Colleagues,

Interstitial lung diseases (ILDs) are chronic, parenchymal lung diseases with a variable clinical course and poor prognosis. The prevalence and incidence of ILD have been increasing. Accurate diagnosis is essential for better outcomes, but accurate diagnosis of ILD remains a major medical challenge due to the variability of clinical presentation and diagnostic uncertainty of current diagnostic tests. Multidisciplinary discussion (MDD) has been becoming the cornerstone of diagnosis of ILD, and the scope of MDD has expanded to monitoring disease progression comprising other specialists including cardiac surgeons, rheumatologists, and physiotherapists.

Within various clinical courses, acute exacerbation (AE) is a devastating condition with significant morbidity and high mortality. Additionally, progressive pulmonary fibrosis (PPF) implies the worsening of any preexisting ILD despite appropriate treatment and was recently defined in the ATS/ERS/JRS/ALAT guidelines. For better prognosis, early prediction and adequate treatment of AE and PPF are essential, even considering the limitations of real practice.

Two anti-fibrotic agents have been used worldwide and have significantly reduced lung function decline in patients with IPF. However, there are still many challenges to practical implementation such as the prediction of the treatment response, adequate methods of anti-fibrotic agents and other drugs, and the target disease of ILDs. Drugs other than anti-fibrotic agents and non-pharmacological treatment are also very important in patients with ILD.

This Special Issue will focus on the clinical features, diagnosis, and management of ILDs.

Dr. Jae Ha Lee
Dr. Hyun Kyung Lee
Guest Editors

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Keywords

  • interstitial lung disease
  • idiopathic pulmonary fibrosis
  • diagnosis
  • treatment
  • prognosis

Published Papers (1 paper)

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Research

13 pages, 1433 KiB  
Article
Efficacy of Digital Therapeutics for Pulmonary Rehabilitation: A Multi-Center, Randomized Controlled Trial
by Chul Kim, Hee-Eun Choi, Chin Kook Rhee, Jun Hyeong Song and Jae Ha Lee
Life 2024, 14(4), 469; https://doi.org/10.3390/life14040469 - 3 Apr 2024
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Abstract
Background: This study aimed to investigate the efficacy and safety of digital therapeutics (DTx), EASYBREATH, for pulmonary rehabilitation (PR) in patients with chronic respiratory diseases (CRDs). Materials and Methods: This prospective randomized controlled trial was conducted at multiple centers. Participants were randomly allocated [...] Read more.
Background: This study aimed to investigate the efficacy and safety of digital therapeutics (DTx), EASYBREATH, for pulmonary rehabilitation (PR) in patients with chronic respiratory diseases (CRDs). Materials and Methods: This prospective randomized controlled trial was conducted at multiple centers. Participants were randomly allocated 1:1 to the DTx group (DTxG), provided with DTx using EASYBREATH. The DTxG underwent an 8-week PR program with evaluations conducted at baseline, four weeks, and eight weeks. The control group (CG) underwent one PR session and was advised to exercise and undergo the same evaluation. The primary outcome was the change in six-minute walking distance (6MWD) over eight weeks, and secondary outcomes included changes in scores of Modified Medical Research Council (mMRC), chronic obstructive pulmonary disease assessment test (CAT), and St. George’s respiratory questionnaire (SGRQ). Results: The change in 6MWD after eight weeks demonstrated a significant difference between the DTxG and CG (57.68 m vs. 21.71 m, p = 0.0008). The change in mMRC scores (p = 0.0008), CAT scores (p < 0.0001), and total SGRQ scores (p = 0.0003) also showed a significant difference between the groups after eight weeks. Conclusions: EASYBREATH significantly improved exercise capacity, alleviated dyspnea, and enhanced the overall quality of life at eight weeks. EASYBREATH is a highly accessible, time-efficient, and effective treatment option for CRD with high compliance. Full article
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