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Life
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New Horizons in Veterinary Neurology
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New Horizons in Veterinary Neurology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Animal Science".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 15094

Special Issue Editors

Prof. Dr. Clare Rusbridge

E-Mail Website
Guest Editor
School of Veterinary Medicine, University of Surrey, Guildford GU7 2QQ, UK
Interests: veterinary neurology; veterinary neuroradiology; veterinary neurosurgery; Chiari malformation; syringomyelia; neuropathic pain; neuropathic itch
Dr. Danielle Whittaker

E-Mail Website
Guest Editor
1. King's College London Guy's Hospital, Great Maze Pond, London SE1 1UL, UK
2. Fitzpatrick Referrals, Halfway Lane, Eashing GU7 2QQ, UK
Interests: veterinary neurology; brain development; cerebellum development; neurodevelopmental disorders; delayed motor development; ataxia; intellectual disability; GABAergic fate specification

Special Issue Information

Dear Colleagues,

New Horizons in Veterinary Neurology is a Special Issue of Life that focuses on new developments in clinical veterinary neurology including neuroradiology, neurosurgery, the diagnosis and treatment of central and peripheral nervous system diseases including neuromuscular disorders, rehabilitation, neuroanesthesia and pain management, neuropathology, neuroanatomy and neuropharmacology. Original manuscripts covering all aspects of Veterinary Neurology in domestic and non-domestic animals are invited. Papers reporting novel solutions to common problems and novel descriptions of less commonly recognized conditions are particularly welcome. We also invite original research on translational studies that provide insight into diagnosing and treating neurological conditions in all species.

Prof. Dr. Clare Rusbridge
Dr. Danielle Whittaker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • canine
  • feline
  • brain disorders
  • spinal disorders
  • epilepsy
  • movement disorders
  • MRI
  • veterinary neurosurgery
  • neurodevelopment
  • neuropathic pain
  • neuromuscular disorders
  • translational studies
  • one health

Published Papers (3 papers)

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Research

15 pages, 3064 KiB  
Article
Slosh Simulation in a Computer Model of Canine Syringomyelia
by Srdjan Cirovic and Clare Rusbridge
Life 2021, 11(10), 1083; https://doi.org/10.3390/life11101083 - 14 Oct 2021
Cited by 2 | Viewed by 3328
Abstract
The exact pathogenesis of syringomyelia is unknown. Epidural venous distention during raised intrathoracic pressure (Valsalva) may cause impulsive movement of fluid (“slosh”) within the syrinx. Such a slosh mechanism is a proposed cause of syrinx dissection into spinal cord parenchyma resulting in craniocaudal [...] Read more.
The exact pathogenesis of syringomyelia is unknown. Epidural venous distention during raised intrathoracic pressure (Valsalva) may cause impulsive movement of fluid (“slosh”) within the syrinx. Such a slosh mechanism is a proposed cause of syrinx dissection into spinal cord parenchyma resulting in craniocaudal propagation of the cavity. We sought to test the “slosh” hypothesis by epidural excitation of CSF pulse in a computer model of canine syringomyelia. Our previously developed canine syringomyelia computer model was modified to include an epidural pressure pulse. Simulations were run for: cord free of cavities; cord with small syringes at different locations; and cord with a syrinx that was progressively expanding caudally. If small syringes are present, there are peaks of stress at those locations. This effect is most pronounced at the locations at which syringes initially form. When a syrinx is expanding caudally, the peak stress is typically at the caudal end of the syrinx. However, when the syrinx reaches the lumbar region; the stress becomes moderate. The findings support the “slosh” hypothesis, suggesting that small cervical syringes may propagate caudally. However, when the syrinx is large, there is less focal stress, which may explain why a syrinx can rapidly expand but then remain unchanged in shape over years. Full article
(This article belongs to the Special Issue New Horizons in Veterinary Neurology)
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15 pages, 2118 KiB  
Article
Evaluation of a Novel Dorsal-Cemented Technique for Atlantoaxial Stabilisation in 12 Dogs
by Joana Tabanez, Rodrigo Gutierrez-Quintana, Adriana Kaczmarska, Roberto José-López, Veronica Gonzalo Nadal, Carina Rotter and Guillaume Leblond
Life 2021, 11(10), 1039; https://doi.org/10.3390/life11101039 - 02 Oct 2021
Cited by 3 | Viewed by 4403
Abstract
Dorsal atlantoaxial stabilisation (DAAS) has mostly been described to treat atlantoaxial instability using low stiffness constructs in dogs. The aim of this study was to assess the feasibility and surgical outcome of a rigid cemented DAAS technique using bone corridors that have not [...] Read more.
Dorsal atlantoaxial stabilisation (DAAS) has mostly been described to treat atlantoaxial instability using low stiffness constructs in dogs. The aim of this study was to assess the feasibility and surgical outcome of a rigid cemented DAAS technique using bone corridors that have not previously been reported. The medical records of 12 consecutive dogs treated with DAAS were retrospectively reviewed. The method involved bi-cortical screws placed in at least four of eight available bone corridors, embedded in polymethylmethacrylate. Screw placement was graded according to their position and the degree of the breach from the intended bone corridor. All DAAS procedures were completed successfully. A total of 72 atlantoaxial screws were placed: of those, 51 (70.8%) were optimal, 17 (23.6%) were suboptimal, and 4 (5.6%) were graded as hazardous (including 2 minor breaches of the vertebral canal). Surgical outcome was assessed via a review of client questionnaires, neurological examination, and postoperative CT images. The clinical outcome was considered good to excellent in all but one case that displayed episodic discomfort despite the appropriate atlantoaxial reduction. A single construct failure was identified despite a positive clinical outcome. This study suggests the proposed DAAS is a viable alternative to ventral techniques. Prospective studies are required to accurately compare the complication and success rate of both approaches. Full article
(This article belongs to the Special Issue New Horizons in Veterinary Neurology)
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11 pages, 4897 KiB  
Article
Canine Lafora Disease: An Unstable Repeat Expansion Disorder
by Thilo von Klopmann, Saija Ahonen, Irene Espadas-Santiuste, Kaspar Matiasek, Daniel Sanchez-Masian, Stefan Rupp, Helene Vandenberghe, Jeremy Rose, Travis Wang, Peixiang Wang, Berge Arakel Minassian and Clare Rusbridge
Life 2021, 11(7), 689; https://doi.org/10.3390/life11070689 - 14 Jul 2021
Cited by 8 | Viewed by 5707
Abstract
Canine Lafora disease is a recessively inherited, rapidly progressing neurodegenerative disease caused by the accumulation of abnormally constructed insoluble glycogen Lafora bodies in the brain and other tissues due to the loss of NHL repeat containing E3 ubiquitin protein ligase 1 (NHLRC1 [...] Read more.
Canine Lafora disease is a recessively inherited, rapidly progressing neurodegenerative disease caused by the accumulation of abnormally constructed insoluble glycogen Lafora bodies in the brain and other tissues due to the loss of NHL repeat containing E3 ubiquitin protein ligase 1 (NHLRC1). Dogs have a dodecamer repeat sequence within the NHLRC1 gene, which is prone to unstable (dynamic) expansion and loss of function. Progressive signs of Lafora disease include hypnic jerks, reflex and spontaneous myoclonus, seizures, vision loss, ataxia and decreased cognitive function. We studied five dogs (one Chihuahua, two French Bulldogs, one Griffon Bruxellois, one mixed breed) with clinical signs associated with canine Lafora disease. Identification of polyglucosan bodies (Lafora bodies) in myocytes supported diagnosis in the French Bulldogs; muscle areas close to the myotendinous junction and the myofascial union segment had the highest yield of inclusions. Postmortem examination of one of the French Bulldogs revealed brain Lafora bodies. Genetic testing for the known canine NHLRC1 mutation confirmed the presence of a homozygous mutation associated with canine Lafora disease. Our results show that Lafora disease extends beyond previous known breeds to the French Bulldog, Griffon Bruxellois and even mixed-breed dogs, emphasizing the likely species-wide nature of this genetic problem. It also establishes these breeds as animal models for the devastating human disease. Genetic testing should be used when designing breeding strategies to determine the frequency of the NHLRC1 mutation in affected breeds. Lafora diseases should be suspected in any older dog presenting with myoclonus, hypnic jerks or photoconvulsions. Full article
(This article belongs to the Special Issue New Horizons in Veterinary Neurology)
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