Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.7
3.2
Journals
Life
Special Issues
Advance in Pathogenesis and Controlling of Streptococcus suis
share announcement

Advance in Pathogenesis and Controlling of Streptococcus suis

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3392

Special Issue Editor

Dr. Anding Zhang

E-Mail Website
Guest Editor
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
Interests: Streptococcus suis; diagnosis kits development; veterinary vaccine development

Special Issue Information

Dear Colleagues,

Streptococcus suis (S. suis) is a major swine pathogen that is responsible for severe economic losses in the porcine industry and represents a significant threat to pig or pork-contacting peoples and immunocompetent patients. Since the outbreaks of two epidemics of human S. suis diseases in China, significant progress on the pathogenesis of S. suis diseases has been achieved. To provide a reference for further research, we would like to invite researchers to contribute review papers or original research papers on the following topics based on your expertise: 1) epidemiology, genome variation, or evolution; 2) growth, cell division, and pathogenicity; 3) virulence-associated factors; 4) gene regulation networks; 5) interaction of bacteria and host cells (including adherence, invasion of host cells, and evasion of killings by immune cells); 6) signaling pathways for immune response; 7) pathogenesis for streptococcal toxic shock-like syndrome; 8) pathogenesis for meningitis; 9) vaccine developments; and 10) development of antimicrobials.

Dr. Anding Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Streptococcus suis
  • epidemiology
  • genome variation
  • cell division
  • pathogenicity
  • virulence-associated factors
  • gene regulation network
  • interaction of bacteria and host cells
  • immune response
  • streptococcal toxic shock-like syndrome
  • meningitis
  • vaccine
  • antimicrobials
 
 

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 3933 KiB  
Article
Suilyin Disrupts the Blood–Brain Barrier by Activating Group III Secretory Phospholipase A2
by Yutong Sui, Ying Chen, Qingyu Lv, Yuling Zheng, Decong Kong, Hua Jiang, Wenhua Huang, Yuhao Ren, Peng Liu and Yongqiang Jiang
Life 2022, 12(6), 919; https://doi.org/10.3390/life12060919 - 20 Jun 2022
Cited by 3 | Viewed by 1587
Abstract
Serious diseases caused by Streptococcus suis serotype 2 (S. suis 2) include septicaemia and meningitis, which are associated with high morbidity and mortality. Proliferation in the blood can result in a breach of the blood–brain barrier (BBB) and provide entry into the [...] Read more.
Serious diseases caused by Streptococcus suis serotype 2 (S. suis 2) include septicaemia and meningitis, which are associated with high morbidity and mortality. Proliferation in the blood can result in a breach of the blood–brain barrier (BBB) and provide entry into the cerebrospinal fluid (CSF), where bacteria cause inflammation of the meningeal membranes resulting in meningitis. The molecular mechanisms of how this pathogen crosses the BBB remain unclear. Suilysin (SLY) has been identified as an important secreted virulence factor of S. suis 2 and may play a vital role in provoking meningitis. In this investigation, we demonstrate that SLY can increase the paracellular permeability of BBB, both in vivo and in vitro, via the activation of group III secretory phospholipase A2 (PLA2G3). Our results indicate that at lower, sublytic concentrations, the toxin can stimulate cerebral microvascular endothelial cells to release TNF-α, thereby inducing high level expressions of PLA2G3. Abnormal elevations of PLA2G3 might further injure tissues through direct cytolytic effectors or other responses. Full article
(This article belongs to the Special Issue Advance in Pathogenesis and Controlling of Streptococcus suis)
►▼ Show Figures

Figure 1

Review

Jump to: Research

12 pages, 5988 KiB  
Review
Bringing Antimicrobial Strategies to a New Level: The Quorum Sensing System as a Target to Control Streptococcus suis
by Bingqian Xue, Yamin Shen, Jing Zuo, Dong Song, Qingying Fan, Xiaoling Zhang, Li Yi and Yang Wang
Life 2022, 12(12), 2006; https://doi.org/10.3390/life12122006 - 01 Dec 2022
Cited by 2 | Viewed by 1348
Abstract
Streptococcus suis (S. suis) is an important zoonotic pathogen. It mainly uses quorum sensing (QS) to adapt to complex and changeable environments. QS is a universal cell-to-cell communication system that has been widely studied for its physiological functions, including the regulation of bacterial [...] Read more.
Streptococcus suis (S. suis) is an important zoonotic pathogen. It mainly uses quorum sensing (QS) to adapt to complex and changeable environments. QS is a universal cell-to-cell communication system that has been widely studied for its physiological functions, including the regulation of bacterial adhesion, virulence, and biofilm formation. Quorum sensing inhibitors (QSIs) are highly effective at interfering with the QS system and bacteria have trouble developing resistance to them. We review the current research status of the S. suis LuxS/AI-2 QS system and QSIs. Studies showed that by inhibiting the formation of AI-2, targeting the LuxS protein, inhibiting the expression of luxs gene can control the LuxS/AI-2 QS system of S. suis. Other potential QSIs targets are summarized, which may be preventing and treating S. suis infections, including AI-2 production, transmission, LuxS protein, blockage of AI-2 binding to receptors, AI-2-mediated QS. Since antibiotics are becoming increasingly ineffective due to the emergence of resistant bacteria, including S. suis, it is thus critical to find new antibacterial drugs with different mechanisms of action. QSIs provide hope for the development of such drugs. Full article
(This article belongs to the Special Issue Advance in Pathogenesis and Controlling of Streptococcus suis)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop