Exploring the Potential of Natural Compounds as Anticancer Agents

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 3430

Special Issue Editors


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Guest Editor
Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia 1683, Cyprus
Interests: breast cancer; estrogen receptors; tamoxifen resistance

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Guest Editor
Apoptosis and Cancer Chemoresistance Laboratory, Basic and Translational Cancer Research Center, Department of Life Sciences, European University Cyprus, Nicosia 2404, Cyprus
Interests: targeted cancer therapy; apoptosis; metastasis; cancer chemoresistance; pancreatic cancer; breast cancer; lung cancer
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Guest Editor
Department of Pharmacodynamics and Clinical Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania
Interests: pharmacology; polyphenols; traditional medicine; cancer biology

Special Issue Information

Dear Colleagues,

It is a pleasure to invite you to contribute to this Special Issue of Life, which aims to collect the most recent information on a diverse range of innovative therapies for the treatment of cancer.

Despite continuous advances in the development of new anticancer drugs, cancer remains a significant threat to human health and one of the leading causes of death worldwide. With the rising number of cancer-related deaths, it has become imperative to develop therapeutic approaches that are effective with minimal cytotoxic side effects and resistance. In recent years, several compounds, such as small molecules, engineered antibodies, immunomodulators, and others, have been approved for cancer treatment. Despite the application of multiple modern and expensive treatments to combat cancer and limit its lethality, the results have not been particularly encouraging.

Recent research suggests a growing interest in using natural compounds in addition to chemotherapy as an adjuvant treatment to enhance the therapeutic index of certain anti-neoplastic drugs. Natural compounds possess a range of advantageous activities, such as promoting good health and aiding in cancer treatment, being an invaluable and practical source of anticancer agents. A positive trend has been shown in using them in preclinical research, inspiring numerous innovative strategies to combat cancer and expedite clinical research.

In addition, due to their unique molecular properties, natural products can provide superior efficacy and safety, as they do not have toxic effects towards normal cells but are more selective against cancer cells.

The aim of this Special Issue is to provide an overview of novel formulations of natural products as a means of treating and preventing cancer, as well as the molecular mechanisms that underscore their anticancer properties.

Dr. Christiana Charalambous
Dr. Christiana M. Neophytou
Dr. Alexandru Vasincu
Guest Editors

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Keywords

  • cancer
  • chemoprevention
  • natural compounds
  • cancer signaling pathways
  • immunotherapeutics
  • molecular mechanisms
  • apoptosis
  • angiogenesis inhibitors

Published Papers (2 papers)

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Research

17 pages, 2170 KiB  
Article
Antioxidant and Anticancer Activity of Vitis vinifera Extracts in Breast Cell Lines
by Evgenia Maria Tsantila, Nils Esslinger, Maria Christou, Panagiotis Papageorgis and Christiana M. Neophytou
Life 2024, 14(2), 228; https://doi.org/10.3390/life14020228 - 6 Feb 2024
Viewed by 1378
Abstract
Vitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported. In this study, we produced twelve extracts from the seeds, fruit, leaves, and wood of [...] Read more.
Vitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported. In this study, we produced twelve extracts from the seeds, fruit, leaves, and wood of the Vitis vinifera Airen variety using different extraction methodologies and measured their total polyphenol content (TPC). We also determined their antioxidant and antiproliferative effects against normal cells and evaluated the most potent extract against a panel of breast cancer cell lines. We found that the extracts produced by the seeds of Vitis vinifera had a higher TPC compared to the other parts of the plant. Most extracts produced from seeds had antioxidant activity and did not show cytotoxicity against normal breast cells. The extract produced from whole organic seeds of white grape showed the best correlation between the dose and the ROS inhibition at all time points compared to the other seed extracts and also had antiproliferative properties in estrogen-receptor-positive MCF-7 breast cancer cells. Its mechanism of action involves inhibition of proteins Bcl-2, Bcl-xL, and survivin, and induction of apoptosis. Further investigation of the constituents and activity of Vitis vinifera extracts may reveal potential pharmacological applications of this plant. Full article
(This article belongs to the Special Issue Exploring the Potential of Natural Compounds as Anticancer Agents)
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14 pages, 1353 KiB  
Article
Evaluation of Antioxidant Activity, Cytotoxicity, and Genotoxicity of Ptychotis verticillata Essential Oil: Towards Novel Breast Cancer Therapeutics
by Mohamed Taibi, Amine Elbouzidi, Sabir Ouahhoud, El Hassania Loukili, Douâae Ou-Yahya, Safae Ouahabi, Ali S. Alqahtani, Omar M. Noman, Mohamed Addi, Reda Bellaouchi, Abdeslam Asehraou, Ennouamane Saalaoui, Bouchra El Guerrouj and Khalid Chaabane
Life 2023, 13(7), 1586; https://doi.org/10.3390/life13071586 - 19 Jul 2023
Cited by 8 | Viewed by 1480
Abstract
Breast cancer is a disease characterized by the uncontrolled proliferation of malignant cells in breast tissue, and oxidative stress activated by an accumulation of reactive oxygen species (ROS) is associated with its development and progression. Essential oils from medicinal plants, known for their [...] Read more.
Breast cancer is a disease characterized by the uncontrolled proliferation of malignant cells in breast tissue, and oxidative stress activated by an accumulation of reactive oxygen species (ROS) is associated with its development and progression. Essential oils from medicinal plants, known for their antioxidant and therapeutic properties, are being explored as alternatives. Ptychotis verticillata, also known as Nûnkha, is a medicinal plant native to Morocco, belonging to the Apiaceae family, and used for generations in traditional medicine. This study focuses on the phytochemical characterization of P. verticillata essential oil (PVEO) from the province of Oujda, Morocco, for its therapeutic properties. The essential oil was obtained by hydro-distillation, and its volatile components were analyzed by gas chromatography-mass spectrometry (GC-MS). The results revealed the presence of various aromatic and terpene compounds, with carvacrol being the most abundant compound. PVEO showed antioxidant properties in several tests, including β-carotene bleaching, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and total antioxidant capacity (TAC). It also demonstrated cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cell lines, with higher selectivity for MDA-MB-231. The results reveal that Ptychotis verticillata essential oil (PVEO) could be a promising natural alternative for the treatment of breast cancer, Full article
(This article belongs to the Special Issue Exploring the Potential of Natural Compounds as Anticancer Agents)
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