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Life
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Frontiers in Neuroregeneration
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Frontiers in Neuroregeneration

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 13003

Special Issue Editors

Prof. Dr. Kiminobu Sugaya

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Guest Editor
College of Medicine, University of Central Florida, Orlando, FL 32816, USA
Interests: stem cell; Alzheimer’s disease; neurodegenerative diseases; down syndrome; regeneration therapy; cancer stem cell; exosome
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Frederick Robert Carrick

E-Mail Website
Guest Editor
Professor of Neurology, College of Medicine, University of Central Florida, Orlando, FL 32827, USA
Interests: neurology; movement disorders; concussion; neuro degeneration; medical education
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mohtashem Samsam

E-Mail Website
Guest Editor
Department of Physical Therapy, Advent Health University (AHU), Orlando, FL 32803, USA
Interests: neurodegenerative diseases; autism spectrum disorders; inflammation in and treatment of neurological and psychiatric disorders; mechanisms of primary headache disorders

Special Issue Information

Dear Colleagues,

The neurodegenerative disease therapies on the market today are symptomatic treatments. Many pharmaceutical companies have tried to develop a cure for Alzheimer’s disease by focusing on immunotherapy and other forms of therapy to eliminate Aβ deposition. However, to date, all their efforts to prevent plaque formation have failed to benefit patients, after the investment of billions of dollars. There is a need to establish a treatment method from an entirely different perspective.

It has been quite a while since we showed that neural stem cell (NSC) transplantation improved the cognition of aged animals. However, it is challenging to obtain NSCs for transplantation since they are localized deep in the brain. We have developed technologies to produce pluripotent stem cells from somatic cells, which allows us to use autologous stem cells for transplantation. However, there remains the issue of controlling cell fate and the development of tumors. Thus, we believe that it will take more time for cell-transplantation-based neuroregenerative therapy to contribute to medicine.

In this Special Issue, we would like to cover new concepts in neuroregeneration therapies, including but not limited to using small molecular compounds to increase neurogenesis. The submission of not only research articles but also scientific perspectives or comprehensive reviews is welcome.

Prof. Dr. Kiminobu Sugaya
Prof. Dr. Frederick Robert Carrick
Prof. Dr. Mohtashem Samsam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • neuroregeneration
  • stroke
  • regenerative therapy

Published Papers (2 papers)

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Research

24 pages, 8536 KiB  
Article
The Pupillary Light Reflex as a Biomarker of Concussion
by Frederick Robert Carrick, Sergio F. Azzolino, Melissa Hunfalvay, Guido Pagnacco, Elena Oggero, Ryan C. N. D’Arcy, Mahera Abdulrahman and Kiminobu Sugaya
Life 2021, 11(10), 1104; https://doi.org/10.3390/life11101104 - 18 Oct 2021
Cited by 12 | Viewed by 5650
Abstract
The size of our pupils changes continuously in response to variations in ambient light levels, a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its function is modulated by cognitive brain function and any long-term [...] Read more.
The size of our pupils changes continuously in response to variations in ambient light levels, a process known as the pupillary light reflex (PLR). The PLR is not a simple reflex as its function is modulated by cognitive brain function and any long-term changes in brain function secondary to injury should cause a change in the parameters of the PLR. We performed a retrospective clinical review of the PLR of our patients using the BrightLamp Reflex iPhone app. The PLR variables of latency, maximum pupil diameter (MaxPD), minimum pupil diameter (MinPD), maximum constriction velocity (MCV), and the 75% recovery time (75% PRT) were associated with significant differences between subjects who had suffered a concussion and those that had not. There were also significant differences in PLR metrics over the life span and between genders and those subjects with and without symptoms. The differences in PLR metrics are modulated not only by concussion history but also by gender and whether or not the person has symptoms associated with a head injury. A concussive injury to the brain is associated with changes in the PLR that persist over the life span, representing biomarkers that might be used in clinical diagnosis, treatment, and decision making. Full article
(This article belongs to the Special Issue Frontiers in Neuroregeneration)
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15 pages, 5374 KiB  
Article
Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket
by Frederick Robert Carrick, Luis Sebastian Alexis Valerio, Maxine N. Gonzalez-Vega, David Engel and Kiminobu Sugaya
Life 2021, 11(9), 878; https://doi.org/10.3390/life11090878 - 26 Aug 2021
Cited by 3 | Viewed by 6582
Abstract
Introduction: Wounds are associated with ranges of simple to complex disruption or damage to anatomical structure and function. They are also associated with enormous economic and social costs, increasing yearly, resulting in a severe impact on the wellbeing of individuals and society. Technology [...] Read more.
Introduction: Wounds are associated with ranges of simple to complex disruption or damage to anatomical structure and function. They are also associated with enormous economic and social costs, increasing yearly, resulting in a severe impact on the wellbeing of individuals and society. Technology that might accelerate wound healing is associated with many benefits to injured people. Methods: BALBc mice underwent symmetrical excisional wounds through the panniculus carnosus. They were divided into a treatment group placed on an autonomous ceramic far-field infrared blanket (cIFRB) and a control group maintained under standard conditions. We also expanded and cultured adipose tissue-derived mesenchymal stem cells (MSCs) on cIFRB and compared them to standard conditions subjected to a scratch injury to compare survival, proliferation, and wound healing. Results: The wound healing of the cIRFB treatment group was significantly faster than the control group of mice. The wound-healing effect of mesenchymal stem cells on cIRFB was also increased and associated with significant migration to the wound area. Conclusions: Wound healing is improved in a mouse model exposed to cFIRB. The ceramic blanket also promotes survival, proliferation, increased migration, and wound healing of MSCs without affecting their survival and proliferation. The utilization of cFIRB in cellular biology and medical applications may be promising in many situations currently explored in animal and human models. This technology needs no direct or battery power source and is entirely autonomous and noninvasive, making its application possible in any environment. Full article
(This article belongs to the Special Issue Frontiers in Neuroregeneration)
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