Metabolism and Immunity: Therapeutic Potential of Polyunsaturated Fatty Acids and Their Derivatives
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 2366
Special Issue Editor
Special Issue Information
Dear Colleagues,
Fatty acids (FAs) are precursors of several lipid species and mediators, including phospholipids, sphingolipids and triacylglycerols as well as eicosanoids, endocannabinoids and isoprostanes. FAs are involved in the synthesis of biological membranes and the modulation of their fluidity, functioning as secondary messengers in signaling pathways to maintain homoeostasis, and serving as a form of energy storage in animals. Recent reports clearly indicate that polyunsaturated FAs (PUFAs) and their derivatives are essential for proper growth and development, have immunomodulatory and anti-inflammatory properties, and are resolvers of inflammation. The specific molecular mechanism for the health benefits from n-3 and n-6 PUFAs remain unclear.
Metabolic inflammation is hypothesized to arise from chronic nutrient excess. The relationship between the immune and metabolic responses includes both communicable (infection) and non-communicable diseases (diabetes, CVD, and cancer). A greater understanding of the critical nodes of immune metabolism may provide opportunities to break the tight connections between defects in metabolism and immunity that propagate disease.
The process of the resolution of inflammation, so important for the health of the patient, is still not fully understood. Therefore, characterizing the molecular mechanism of the resolution of inflammation is important. It may allow, inter alia, the development of new strategies, therapeutic aims and modern drugs, essential in the fight against inflammation.
Dr. Joanna Gdula-Argasińska
Guest Editor
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Keywords
- polyunsaturated fatty acids
- pro-resolving mediators
- lipidomic remodeling
- lipid reprogramming
- immune cells
- astrocyte–microglia communication
- bone marrow fat
