Exercise Discussion in the Cardiovascular Field

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1269

Special Issue Editor

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Guest Editor
Institute of Sports Sciences, University of Taipei, Taipei 11153, Taiwan
Interests: exercise physiology; cardiovascular physiology; metabolic syndrome; cardiopulmonary function; aging; physical therapy
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Dear Colleagues,

We are organizing a Special Issue of Life, with the aim of collating international, peer-reviewed and open access scientific studies related to fundamental themes in life sciences, from basic to applied research. For detailed information on the journal, please refer to https://www.mdpi.com/journal/life/.

Exercise has been known to alleviate most cardiovascular risk factors and improve cardiovascular health, especially for those with chronic diseases and the aging population. According to the ACSM recommendations, moderate- or vigorous-intensity aerobic exercise, as well as physical activities that maintain or increase muscular strength and endurance, are suggested for people of all ages and special populations. Exploration of the influences from various types or strategies of exercise on cardiovascular health should be discussed for improving the overall health care. This Special Issue is open to any subject area related to the influence of exercise in the cardiovascular field. The listed keywords suggest just a few of the many possibilities.

Prof. Dr. Ai-Lun Yang
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aerobic exercise
  • resistance exercise
  • athletic training
  • blood pressure
  • arterial stiffness
  • endothelial function
  • cardiovascular disease
  • aging

Published Papers (1 paper)

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17 pages, 4195 KiB  
A Comparative Study: Cardioprotective Effects of High-Intensity Interval Training Versus Ischaemic Preconditioning in Rat Myocardial Ischaemia–Reperfusion
by Jia-Yuan Zhang, Szu-Kai Fu, Hsia-Ling Tai, Kuo-Wei Tseng, Chia-Yu Tang, Chia-Hsien Yu and Chang-Chi Lai
Life 2024, 14(3), 310; https://doi.org/10.3390/life14030310 - 27 Feb 2024
Cited by 1 | Viewed by 939
(1) Background: Years of research have identified ischemic preconditioning (IPC) as a crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury, enhancing the myocardial cell’s tolerance to subsequent ischemic damage. High-intensity interval training (HIIT) is promoted by athletes because it reduces exercise duration and [...] Read more.
(1) Background: Years of research have identified ischemic preconditioning (IPC) as a crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury, enhancing the myocardial cell’s tolerance to subsequent ischemic damage. High-intensity interval training (HIIT) is promoted by athletes because it reduces exercise duration and improves metabolic response and cardiopulmonary function. Our objective was to evaluate and compare whether HIIT and IPC could reduce myocardial ischemia and reperfusion injury in rats. (2) Methods: Male Sprague-Dawley rats were divided into four groups: sham surgery, coronary artery occlusion (CAO), high-intensity interval training (HIIT), and ischemic preconditioning (IPC). The CAO, HIIT, and IPC groups experienced 40 min of coronary artery occlusion followed by 3 h of reperfusion to induce myocardial ischemia–reperfusion injury. Subsequently, the rats were sacrificed, and blood samples along with cardiac tissues were examined. The HIIT group received 4 weeks of training before surgery, and the IPC group underwent preconditioning before the ischemia–reperfusion procedure. (3) Results: The HIIT and IPC interventions significantly reduced the extent of the myocardial infarction size and the levels of serum troponin I and lactate dehydrogenase. Through these two interventions, serum pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, were significantly decreased, while the anti-inflammatory cytokine IL-10 was increased. Furthermore, the expression of pro-apoptotic proteins PTEN, caspase-3, TNF-α, and Bax in the myocardium was reduced, and the expression of anti-apoptotic B-cell lymphoma 2 (Bcl-2) was increased, ultimately reducing cellular apoptosis in the myocardium. In conclusion, both HIIT and IPC demonstrated effective strategies with potential for mitigating myocardial ischemia–reperfusion injury for the heart. Full article
(This article belongs to the Special Issue Exercise Discussion in the Cardiovascular Field)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Home-Based Circuit Training Improves Blood Lipid Profile, Liver Function, Musculoskeletal Fitness, and Health-Related Quality of Life in Overweight/Obese Older Adult Patients with Knee Osteoarthritis and Type 2 Diabetes: A Randomized Con-trolled Trial During the COVID-19 Lockdown
Author: Batrakoulis
Highlights: The present beneficial changes in lipid homeostasis, musculoskeletal fitness and OA-related QoL have public health implications as they suggest a practicable and injury-free exercise solution integrating bodyweight and resistance-based activities into a circuit manner, affecting various metabolic health, physical fitness, and mental health parameters among older adult patients with overweight/obesity, T2DM and KOA in a home-based setting.

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