Genetic Aspects of Vascular Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics".
Deadline for manuscript submissions: 14 June 2024 | Viewed by 1645
Special Issue Editors
Interests: oxidative stress; genetic polymorphisms; microRNA; dietetics
Special Issue Information
Dear Colleagues,
In recent years, the incidence of vascular diseases has been rapidly increasing around the world, causing a serious threat to human health and lives. Disorders of the vascular system include complications affecting blood vessels, primarily, arteries and veins, leading to an ischemic condition. Vascular diseases may manifest, in particular, as atherothrombosis, inflammation, embolism, vasospasm, aneurysm, or hemangioma formation. In addition to modifiable factors such as diet, hypertension or smoking, vascular disorders may be influenced by genetic predisposition, which is one of the non-modifiable factors.
It is known that the risk of many diseases is determined by multiple genes, numerous polymorphic variants of these genes and their interactions with environmental factors. The genetic factors that cause or predispose people to vascular diseases include the variability of genes involved, among others, in the lipid metabolism (in particular, genes related to atherosclerotic plaque formation), inflammation in the vascular wall, blood pressure regulation, function of vascular smooth muscle cells, vascular homeostasis, atherothrombosis or hyperhomocysteinemia. The genetic architecture of a phenotypic trait can be investigated through several approaches, including linkage analysis, candidate gene association studies, genome-wide association studies (GWAS) or genome sequencing.
This Special Issue invites high-quality original research papers, as well as comprehensive reviews, focusing on the roles of genetic factors in the development of vascular diseases, their screening and medical treatment. Research focusing on topics such as genetic polymorphism, candidate gene-based association studies, genetic linkage-analysis, GWAS or genome sequencing is also welcome.
Dr. Katarzyna OszajcaDr. Janusz Szemraj
Guest Editors
Manuscript Submission Information
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Keywords
- genetic polymorphism
- gene mutation
- single nucleotide polymorphism
- insertion/deletion polymorphism
- functional polymorphism
- linkage analysis
- candidate gene association studies
- genome-wide association studies
- vascular disease
- vascular inflammation
- vascular homeostasis
- atherothrombosis
- embolism
- aneurysm
- hemangioma