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Life
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Focus on Colorectal Cancer and Surgery
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Focus on Colorectal Cancer and Surgery

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (17 November 2023) | Viewed by 2715

Special Issue Editors

Dr. Saulius Svagzdys

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Guest Editor
Department of Surgery, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: colorectal surgery, digestive surgery; laparoscopic surgery; surgical oncology
Dr. Paulius Lizdenis

E-Mail Website
Guest Editor
Department of Surgery, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: laparoscopic surgery; colorectal surgery; surgical oncology
Dr. Justas Žilinskas

E-Mail Website
Guest Editor
Department of Surgery, Faculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: general, emergency and trauma surgery; digestive surgery; laparoscopic surgery; surgical oncology; advanced surgical technologies; basic science; colorectal surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Colorectal cancer is the third most common cause of cancer and the fourth most common cause of cancer death in developed countries. Colorectal surgery is the main treatment option for colorectal cancer patients. Recently, developments in this type of surgery and surgery in general have been achieved. In addition, progress in the methods and equipment used in colorectal surgery and surgery in general has been noted.  It is often difficult to keep track of the new devices and methodologies that appear. New research is currently underway and better combinations of treatments are being studied.

The Special Issue aims to discuss advanced treatment methods and the most recent research in the development and introduction of new devices and methods of colorectal cancer treatment.

We accept original articles, clinical trials, systematic reviews and meta-analyses.

Dr. Saulius Svagzdys
Dr. Paulius Lizdenis
Dr. Justas Žilinskas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • laparoscopic and robotic surgery
  • endoscopic and minimal invasive surgery
  • colorectal cancers
  • energy devices
  • staplers

Published Papers (2 papers)

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Research

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13 pages, 4945 KiB  
Article
Evaluation of the Effect of an Intraperitoneal Cytostatic-Loaded Supramolecular Hydrogel on Intestinal Anastomotic Healing in an Animal Model
by Danique J. I. Heuvelings, Anne G. W. E. Wintjens, Audrey C. H. M. Jongen, Maurits J. C. A. M. Gielen, Kaatje Lenaerts, Peter-Paul K. H. Fransen, Marion J. Gijbels, Geert C. van Almen, Patricia Y. W. Dankers, Ignace H. J. T. de Hingh and Nicole D. Bouvy
Life 2023, 13(10), 2076; https://doi.org/10.3390/life13102076 - 18 Oct 2023
Viewed by 1141
Abstract
The prognosis of colorectal cancer patients with peritoneal metastases is very poor. Intraperitoneal drug delivery systems, like supramolecular hydrogels, are being developed to improve local delivery and intraperitoneal residence time of a cytostatic such as mitomycin C (MMC). In this study, we evaluate [...] Read more.
The prognosis of colorectal cancer patients with peritoneal metastases is very poor. Intraperitoneal drug delivery systems, like supramolecular hydrogels, are being developed to improve local delivery and intraperitoneal residence time of a cytostatic such as mitomycin C (MMC). In this study, we evaluate the effect of intraperitoneal hydrogel administration on anastomotic healing. Forty-two healthy Wistar rats received a colonic end-to-end anastomosis, after which 6 animals received an intraperitoneal injection with saline, 18 with unloaded hydrogel and 18 with MMC-loaded hydrogel. After 7 days, animals were euthanized, and the anastomotic adhesion and leakage score were measured as primary outcome. Secondary outcomes were bursting pressure, histological anastomosis evaluation and body weight changes. Twenty-two rats completed the follow-up period (saline: n = 6, unloaded hydrogel: n = 10, MMC-loaded hydrogel: n = 6) and were included in the analysis. A trend towards significance was found for anastomotic leakage score between the rats receiving saline and unloaded hydrogel after multiple-comparison correction (p = 0.020, α = 0.0167). No significant differences were found for all other outcomes. The main reason for drop-out in this study was intestinal blood loss. Although the preliminary results suggest that MMC-loaded or unloaded hydrogel does not influence anastomotic healing, the intestinal blood loss observed in a considerable number of animals receiving unloaded and MMC-loaded hydrogel implies that the injection of the hydrogel under the studied conditions is not safe in the current rodent model and warrants further optimalisation of the hydrogel. Full article
(This article belongs to the Special Issue Focus on Colorectal Cancer and Surgery)
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Review

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13 pages, 2901 KiB  
Review
Disposable Duodenoscopes: Evidence and Open Issues
by Clara Benedetta Conti, Fabrizio Cereatti, Raffaele Salerno, Roberto Grassia, Miki Scaravaglio, Carmen Laurenza and Marco Emilio Dinelli
Life 2023, 13(8), 1694; https://doi.org/10.3390/life13081694 - 5 Aug 2023
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Abstract
Duodenoscope-related infections are a major concern in medicine and GI endoscopy, especially in fragile patients. Disposable duodenoscopes seem to be the right tool to minimize the problem: a good choice for patients with many comorbidities or with a high risk of carrying multidrug [...] Read more.
Duodenoscope-related infections are a major concern in medicine and GI endoscopy, especially in fragile patients. Disposable duodenoscopes seem to be the right tool to minimize the problem: a good choice for patients with many comorbidities or with a high risk of carrying multidrug resistant bacteria. Urgent endoscopy could also be a good setting for the use of single-use duodenoscopes, especially when the risk of the infection cannot be evaluated. Their safety and efficacy in performing ERCP has been proven in many studies. However, randomized clinical trials and comparative large studies with reusable scopes are lacking. Moreover, the present early stage of their introduction on the market does not allow a large economical evaluation for each health system. Thus, accurate economical and safety comparisons with cap-disposable duodenoscopes are needed. Moreover, the environmental impact of single-use duodenoscopes should be carefully evaluated, considering the ongoing climate change. In conclusion, definitive guidelines are needed to choose wisely the appropriate patients for ERCP with disposable duodenoscopes as the complete switch to single-use duodenoscopes seems to be difficult, to date. Many issues are still open, and they need to be carefully evaluated in further, larger studies. Full article
(This article belongs to the Special Issue Focus on Colorectal Cancer and Surgery)
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