New Insights in Zika Virus Pathogenicity and Resistance to Infection

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1266

Special Issue Editors


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Guest Editor
Dept. of Pediatrics, Stanford University School of Medicine BMI Rm 2400, 240 Pasteur Drive, Stanford, CA 94305, USA
Interests: virology; viral immunology; viral diseases; virus pathogenesis; virus-host interactions; vaccines; structural biology; innate immunity; maternal health; child health

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Guest Editor
Ragon Institute of MGH MIT and Harvard, Cambridge, MA 02139, USA
Interests: virus pathogenesis; vaccine development; viral immunology; gene therapy; antibody engineering

Special Issue Information

Dear Colleagues,

Zika virus (ZIKV) is a mosquito-borne flavivirus that was initially identified in monkeys in the Zika Forest of Uganda in 1947. Since its first identification in humans in 1952, sporadic cases of ZIVK infection were reported in Africa and Asia. However, in 2007, ZIKV caused a major outbreak in Micronesia, and in the following years several outbreaks were reported in Latin America, especially in Brazil. Zika infection was declared a global public health emergency due its association with microcephaly in newborns and other neurological disorders in adults. As of December 2021, 89 countries and territories have had reported autochthonous mosquito-borne transmission of ZIKV. Despite growing knowledge about ZIKV in the last few years, there are still many questions to be elucidate about ZIKV infection, including pathogenicity, clinical outcomes, immune response and resistance to infection. The main goal of this Special Issue is to capture recent advancements in ZIKV research. For this purpose, we invite you to submit research articles, review articles, and short communications related to ZIKV pathogenicity and resistance to ZIKV infection.

Dr. Maureen Hoch Vieira Fernandes
Dr. Lok Raj Joshi
Guest Editors

Manuscript Submission Information

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Keywords

  • zika virus
  • arbovirus
  • flavivirus
  • ZIKV pathogenicity
  • ZIKV resistance
  • microcephaly
  • maternal health
  • child health
  • Guillain–Barre syndrome

Published Papers (1 paper)

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Review

11 pages, 1394 KiB  
Review
Congenital Zika Virus Syndrome: Microcephaly and Orofacial Anomalies
by Gaetano Scotto, Salvatore Massa, Francesca Spirito and Vincenzina Fazio
Life 2024, 14(1), 55; https://doi.org/10.3390/life14010055 - 28 Dec 2023
Viewed by 861
Abstract
The progressive reappearance of Zika virus (ZIKV) infections since October 2013 and its circulation in >70 countries and territories (from French Polynesia to Brazil and other countries in the Americas, with sporadic spread in Europe and the East) has long been reported as [...] Read more.
The progressive reappearance of Zika virus (ZIKV) infections since October 2013 and its circulation in >70 countries and territories (from French Polynesia to Brazil and other countries in the Americas, with sporadic spread in Europe and the East) has long been reported as a global public health emergency. ZIKV is a virus transmitted by arthropods (arboviruses), mainly by Aedes mosquitoes. ZIKV can also be transmitted to humans through mechanisms other than vector infection such as sexual intercourse, blood transfusions, and mother-to-child transmission. The latter mode of transmission can give rise to a severe clinical form called congenital Zika syndrome (CZS), which can result in spontaneous abortion or serious pathological alterations in the fetus such as microcephaly or neurological and orofacial anomalies. In this study, beside a succinct overview of the etiological, microbiological, and epidemiological aspects and modes of transmission of Zika virus infections, we have focused our attention on the pathogenetic and histopathological aspects in pregnancy and the pathogenetic and molecular mechanisms that can determine microcephaly, and consequently the clinical alterations, typical of the fetus and newborns, in a subject affected by CZS. Full article
(This article belongs to the Special Issue New Insights in Zika Virus Pathogenicity and Resistance to Infection)
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