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Life
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New Insights in Skin Oncology: From Pathogenesis to Treatment
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New Insights in Skin Oncology: From Pathogenesis to Treatment

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 3538

Special Issue Editors

Dr. Alessia Paganelli

E-Mail Website
Guest Editor
Modena University Hospital, Section of Regenerative and Oncological Dermatologic Surgery, Modena, Italy
Interests: skin cancer; melanoma; NMSC; wound healing; mesenchymal stem cells; collagen; rare diseases; cutaneous oncology; dermatologic surgery; dermal substitutes
Dr. Elisabetta Palazzo

E-Mail Website
Guest Editor
DermoLab, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, 41121 Modena, Italy
Interests: skin cancer; squamous cell carcinoma; psoriasis; epidermal homeostasis; keratinocyte stem cells; epidermal differentiation; skin inflammation; mouse models; zebrafish models; in vitro skin 3D model; skin tumor spheroids; next-generation sequencing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin cancers globally represent the most common type of malignancies worldwide and research on this topic is therefore of fundamental importance This call for paper seeks high-quality manuscripts related to the theme of cutaneous oncology.

We encourage researchers both in the setting of basic science and clinical/translational research to submit proposals for papers on a topic of their choice relating to the session theme. Possible topics include:

  • Actinic keratoses
  • NMSCs (including BCC and SCC)
  • Merkel
  • Atypical Fibroxanthoma and Soft Tissue Sarcoma in general
  • Melanoma
  • Cutaneous Lymphoma
  • Vascular Cutaneous Tumors
  • Paraneoplastic manifestations

Papers can be focused either on the pathogenesis and the treatment (medical and/or surgical) of cutaneous neoplasms. Both original research papers and review articles are admitted.

Dr. Alessia Paganelli
Dr. Elisabetta Palazzo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-melanoma skin cancer
  • melanoma
  • lymphoma
  • cutaneous oncology
  • paraneoplastic

Published Papers (2 papers)

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Research

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10 pages, 2042 KiB  
Article
Extra-Anogenital Giant Cutaneous Squamous Cell Carcinomas
by Mateusz K. Mateuszczyk, Iwona Chlebicka, Magdalena Łyko, Joanna Maj and Jacek C. Szepietowski
Life 2024, 14(3), 421; https://doi.org/10.3390/life14030421 - 21 Mar 2024
Viewed by 819
Abstract
Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a [...] Read more.
Extra-anogenital giant cSCCs are rare but have worse outcomes compared to smaller tumors. Prompted by limited data, the authors conducted a retrospective study to gather more information about giant cSCCs to optimize clinical care. We identified seven cases of giant cSCCs from a review of cSCC cases treated in the Unit of Dermatosurgery between 2016 and 2022. Most patients were male (85.71%) with a mean age of 80.29 ± 12.22 years. UV radiation was the most common risk factor (five cases) followed by smoking (three cases) and hidradenitis suppurativa (one case). Most giant cases were located in the head area (71.4%) and the diameter of lesions ranged from 6 to 18 cm. All patients corresponded to tumor stage T3, and 42.86% of patients had lymph node metastases. Surgical excision was the treatment of choice in most cases (85.71%), while a combination of cemiplimab and RP1 was used in some cases due to the ineffectiveness of treatment or contraindications to other therapies. The authors emphasize the importance of early detection and prevention of modifiable risk factors, such as UV radiation, and a multidisciplinary approach to treatment. Other therapies, including immunotherapy, may become increasingly important. Full article
(This article belongs to the Special Issue New Insights in Skin Oncology: From Pathogenesis to Treatment)
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Review

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13 pages, 944 KiB  
Review
Clinical and Dermoscopic Findings of Nevi after Photoepilation: A Review
by Clio Dessinioti, Andriani Tsiakou, Athina Christodoulou and Alexander J. Stratigos
Life 2023, 13(9), 1832; https://doi.org/10.3390/life13091832 - 29 Aug 2023
Viewed by 2045
Abstract
Atypical clinical and dermoscopic findings, or changes in pigmented melanocytic lesions located on body areas treated with lasers or intense pulsed light (IPL) for hair removal (photoepilation), have been described in the literature. There are three prospective studies in a total of 79 [...] Read more.
Atypical clinical and dermoscopic findings, or changes in pigmented melanocytic lesions located on body areas treated with lasers or intense pulsed light (IPL) for hair removal (photoepilation), have been described in the literature. There are three prospective studies in a total of 79 individuals with 287 melanocytic nevi and several case reports reporting the dermoscopic findings and changes after photoepilation. Clinical changes have been reported in 20–100% of individuals, while dermoscopic changes have been observed in 48% to 93% of nevi. More frequent dermoscopic changes included bleaching, the development of pigmented globules, and irregular hyperpigmented areas and regression structures, including gray areas, gray dots/globules, and whitish structureless areas. The diagnostic approach for pigmented lesions with atypical dermoscopic findings and changes after photo-epilation included reflectance confocal microscopy, sequential digital dermoscopy follow-up, and/or excision and histopathology. Challenges pertaining to these diagnostic steps in the context of photoepilation include the detection of findings that may warrant a biopsy to exclude melanoma (ugly duckling, irregular hyperpigmented areas, blue-gray or white areas, and loss of pigment network), the potential persistence of changes at follow-up, and that a histopathologic diagnosis may not be possible due to the distortion of melanocytes or complete regression of the lesion. Furthermore, these diagnostic approaches can be time-consuming, require familiarization of the physician with dermoscopic features, may cause anxiety to the individual, and highlight that avoiding passes of the laser or IPL devices over pigmented lesions is key. Full article
(This article belongs to the Special Issue New Insights in Skin Oncology: From Pathogenesis to Treatment)
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