The Role of Chemokines and Their Receptors in the Disease State
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1079
Special Issue Editors
Interests: cerebrospinal fluid; biomarker; central nervous system diseases
Special Issues, Collections and Topics in MDPI journals
Interests: cancer; central nervous system diseases; cerebrospinal fluid; cytokines; biomarker; inflammation markers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chemokines, also called chemotactic cytokines, are small proteins (about 10 kDa) responsible for coordinating the immune response throughout the body. The characteristic structure of chemokines became the basis for the creation of the chemokine classification, based on differences within the structure of molecules. Conserved cysteines present in their amino acid sequences act as dividing and grouping units for chemokines. The presence and position of the first cysteine residues allowed for the division of these molecules into four groups: CC, CXC, CX3C, and XC. The chemokines assigned to the CC group mainly affect monocytes, basophils, eosinophils, NK cells, dendritic cells, and T cells, and their effect on neutrophils is small. The CXC group was additionally divided into two subgroups (ELR+, ELR-) differing from each other in the presence of the Glu-Leu-Arg motif located in front of the first cysteine. It was noticed that the presence of the ELR motif not only refers to structural changes, but its presence makes chemokines capable of chemotaxis of neutrophils and also influences the angiogenesis process. The ELR+ group includes chemokines that stimulate angiogenesis and significantly affect neutrophils, i.e., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8.
Chemokines were originally discovered due to their leukocyte adhesion, chemotaxis, and activation abilities, both in vivo and in vitro. However, they are also involved in immune surveillance and are able to direct B or T lymphocytes toward the antigen. Thus, chemokines play an important role both in maintaining the normal physiological mechanisms of the body and in the pathological processes that contribute to the onset of the disease.
We call for original papers, reviews, and other forms of scientific communication to provide new findings regarding the role of chemokines and their receptors in the pathophysiology and diagnosis of diseases.
Dr. Olga M. Koper-Lenkiewicz
Dr. Joanna Kamińska
Dr. Marzena Tylicka
Guest Editors
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Keywords
- chemokines
- chemokines receptors
- chemokines’ biological function
- chemokines’ role in the pathophysiology of the disease
- chemokines as pharmacological targets
- immune response
- inflammation
- cancer
