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Life
Special Issues
Retinal Diseases: From Molecular Mechanisms to Therapeutics
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Retinal Diseases: From Molecular Mechanisms to Therapeutics

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1060

Special Issue Editor

Dr. Soo-Young Kim

E-Mail
Guest Editor
Industry Researcher, San Diego, CA, USA
Interests: brain and retina inflammatory diseases; ocular immunology; macrophage; gene and cell therapy; exosome; viral vector; gene delivery; antibody; biologics; bioprocess

Special Issue Information

Dear Colleague,

The aim of this Special Issue is to provide an update of general and genetic retinal diseases and associated molecular pathways and the current stage which the therapeutics approaches are at. General retina diseases include age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, etc. Additionally, genetic retina diseases are not limited, including Leber congenital amaurosis, retinitis pigmentosa, retinoschisis, Stargardt diseases, etc. The most updated therapeutic development approaches and related molecular pathways and pathological aspects of retina diseases will be described and discussed in this Special Issue. The related molecular pathway will be described, and drug development approaches have no limitations, including small molecules, antibodies, peptides, cell and gene therapy, exosomes microbiomes, etc. The Special Issue will provide insights into the validated and developing approaches toward the development of therapeutics in retinal diseases.

Dr. Soo-Young Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal disease
  • inflammatory disease
  • genetic diseases
  • ocular drug development

Published Papers (1 paper)

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Research

14 pages, 2962 KiB  
Article
Investigation of PACAP38 and PAC1 Receptor Expression in Human Retinoblastoma and the Effect of PACAP38 Administration on Human Y-79 Retinoblastoma Cells
by Dénes Tóth, Eszter Fábián, Edina Szabó, Evelin Patkó, Viktória Vicena, Alexandra Váczy, Tamás Atlasz, Tamás Tornóczky and Dóra Reglődi
Life 2024, 14(2), 185; https://doi.org/10.3390/life14020185 - 26 Jan 2024
Viewed by 813
Abstract
Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) [...] Read more.
Retinoblastoma represents the most prevalent malignant neoplasm affecting the eyes in childhood. The clear-cut origin of retinoblastoma has not yet been determined; however, based on experiments, it has been suggested that RB1 loss in cone photoreceptors causes retinoblastoma. Pituitary adenylate-cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide which has been shown to be affected in certain tumorous transformations, such as breast, lung, kidney, pancreatic, colon, and endocrine cancers. This study aimed to investigate potential changes in both PACAP38 and PAC1 receptor (PAC1R) expression in human retinoblastoma and the effect of PACAP38 administration on the survival of a human retinoblastoma cell line (Y-79). We analyzed human enucleation specimens removed because of retinoblastoma for PACAP38 and PAC1R immunostaining and the effect of PACAP38 on the survival of the Y-79 cell line. We described for the first time that human retinoblastoma cells from patients showed only perinuclear, dot-like immunopositivity for both PACAP38 and PAC1R, irrespective of laterality, genetic background, or histopathological features. Nanomolar (100 nM and 500 nM) PACAP38 concentrations had no effect on the viability of Y-79 cells, while micromolar (2 µM and 6 µM) PACAP38 significantly decreased tumor cell viability. These findings, along with general observations from animal studies showing that PACAP38 has strong anti-apoptotic, anti-inflammatory, and antioxidant effects on ocular tissues, together suggest that PACAP38 and its analogs are promising candidates in retinoblastoma therapy. Full article
(This article belongs to the Special Issue Retinal Diseases: From Molecular Mechanisms to Therapeutics)
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