Pathology and Treatment of Vascular Complications during Pregnancy

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1199

Special Issue Editor

E-Mail Website
Guest Editor
Department of Immunology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Interests: pancreatic disorders; polymorphism; genotype; VEGFR-2; vitamin C; Ascorbic acid; Diabetes mellitus; periodontal disease; antigens; Monoclonal Antibody; NLRP3; Citokines; Pro-angiogenic factors; chronic periodontitis; case-control; matrix metalloproteinase; periodontal pa-rameters
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human pregnancy is a complex process. The development of the placenta, for example, is influenced by the molecules secreted by placental trophoblastic cells, as well as by the cells of the immune system in the decidua of the maternal endometrium.

Successful placentation is characterized by an expansion of angiogenesis, essential for improving placental circulation and blood flow with the formation of new vascular beds to allow the growth and vascular development of the placenta.

Placental factors, especially pro-angiogenic and anti-angiogenic proteins, are responsible for placental growth, as well as the vascularization and maintenance of vessel health.

In recent years, evidence has suggested that chronic inflammation, inadequate trophoblast invasion, poor angiogenesis, and the failure of immunological tolerance are co-influential factors in various placental-initiated disorders.

Trophoblast invasion, angiogenesis, and placentation are regulated by the secretion of angiogenesis-regulating molecules, chemokines, and cytokines by phenotypically activated NK cells, T cell subsets, and macrophages.

In this Special Issue, we aim to collect recent knowledge on the study of abnormalities in placental vascular development, and the study of the immunological harmony between mother and fetus, which can lead to various syndromes, such as preeclampsia, premature birth, and intrauterine growth restriction. We will also consider studies addressing the interrelationships between angiogenesis, inflammation, and oxidative stress in pregnancy. Original research articles and reviews are both welcome.

Dr. Mihail Virgil Boldeanu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • maternal–fetal interface
  • placenta
  • immune tolerance
  • implantation
  • decidualization
  • angiogenesis
  • inflammation
  • oxidative stress

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


17 pages, 3924 KiB  
Association between Serum 8-Iso-Prostaglandin F2α as an Oxidative Stress Marker and Immunological Markers in a Cohort of Preeclampsia Patients
by Lidia Boldeanu, Constantin-Cristian Văduva, Daniel Cosmin Caragea, Marius Bogdan Novac, Mariana Manasia, Isabela Siloși, Maria Magdalena Manolea, Mihail Virgil Boldeanu and Anda Lorena Dijmărescu
Life 2023, 13(12), 2242; - 22 Nov 2023
Cited by 1 | Viewed by 831
Background: We aimed to analyze the presence and clinical use of serum 8-iso-prostaglandin F2-alpha (8-iso-PGF2α) as an oxidative stress marker and some inflammatory status biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL-10, high-sensitivity C-reactive protein (hs-CRP), and pentraxin-3 (PTX3)) for patients with [...] Read more.
Background: We aimed to analyze the presence and clinical use of serum 8-iso-prostaglandin F2-alpha (8-iso-PGF2α) as an oxidative stress marker and some inflammatory status biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), IL-10, high-sensitivity C-reactive protein (hs-CRP), and pentraxin-3 (PTX3)) for patients with preeclampsia (PE). Methods: Sixty pregnant women, including thirty diagnosed with PE and thirty who were healthy (NP), were included in this study. For the assessment of serum levels of biomarkers, we used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: Our preliminary study showed that the expression level of serum 8-iso-PGF2α in the PE group was higher than in the PE after delivery (PE-AD) group (742.00 vs. 324.00 pg/mL, p < 0.0001). Groups of preeclamptic patients (PE + PE-AD) expressed significantly elevated levels for all of the assessed inflammatory mediators as compared to NP. Significant strong positive correlations with 8-iso-PGF2α levels were found for systolic blood pressure (SBP), and TNF-α (Spearman’s rho = 0.622, p-value = 0.020 and rho = 0.645, p-value = 0.002, respectively). Our study demonstrates that 8-iso-PGF2α and PTX3 have the greatest diagnostic value for pregnant women with PE. Conclusions: 8-iso-PGF2α and PTX3 can be used as independent predictor factors, along with already-known cytokines, that could represent a prophylactic way to help clinicians identify or predict which pregnant women will develop PE. Full article
(This article belongs to the Special Issue Pathology and Treatment of Vascular Complications during Pregnancy)
Show Figures

Figure 1

Back to TopTop