Coagulation and Its Disorders: From Molecular Mechanisms to Clinical Management
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 30 July 2024 | Viewed by 635
Special Issue Editor
Special Issue Information
Dear Colleagues,
Coagulation is a dynamic process triggered by controlled proteolytic activation through the intrinsic and extrinsic pathways that include a set of coagulation proteins. Any genetic mutation or functional defect involving coagulation factors modifies thrombin generation, resulting in bleeding or thrombosis. Several infectious and inflammatory diseases, organ failures, genetic mutations, and syndromes may impact coagulation mechanisms, with consequences ranging from minor alterations to severe disseminated intravascular coagulation (DIC). Also, pharmacological treatments may have repercussions in the coagulation system.
Understanding the molecular mechanisms of diseases is the basis of supervising coagulative impairments and may help to develop new therapeutic approaches to rescue or control the proteolytic cascade. New-drug development and experimentation may help to modulate them and to prevent bleeding or clot formation, resulting in clinical features and prognosis enhancement when translated in animal models or in humans.
Laboratory diagnostics plays a crucial role in diagnosis and treatment paths. Special attention must be paid to the choice of laboratory method, and its execution and dedicated personnel, space, and equipment are indispensable.
This Special Issue aims to collect the most recent knowledge in the field, accepting original research articles and reviews related to coagulation disorders, their molecular mechanisms, diagnostic tests, and novel treatment strategies.
Dr. Anna Lisa Montemari
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- coagulation
- bleeding disorders
- thrombotic mechanisms
- animal models
- molecular mechanisms
- disseminated intravascular coagulation
- fibrinolysis
- new diagnostic tools and treatment
- inflammatory response
- thrombin generation
- coagulation alterations induced by hepatic and metabolic disorders
- drug-induced coagulation alterations
