Coagulation and Its Disorders: From Molecular Mechanisms to Clinical Management

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 971

Special Issue Editor


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Guest Editor
Clinical Laboratory Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Interests: coagulation; inflammation; diabetes; laboratory medicine

Special Issue Information

Dear Colleagues,

Coagulation is a dynamic process triggered by controlled proteolytic activation through the intrinsic and extrinsic pathways that include a set of coagulation proteins. Any genetic mutation or functional defect involving coagulation factors modifies thrombin generation, resulting in bleeding or thrombosis. Several infectious and inflammatory diseases, organ failures, genetic mutations, and syndromes may impact coagulation mechanisms, with consequences ranging from minor alterations to severe disseminated intravascular coagulation (DIC). Also, pharmacological treatments may have repercussions in the coagulation system.

Understanding the molecular mechanisms of diseases is the basis of supervising coagulative impairments and may help to develop new therapeutic approaches to rescue or control the proteolytic cascade. New-drug development and experimentation may help to modulate them and to prevent bleeding or clot formation, resulting in clinical features and prognosis enhancement when translated in animal models or in humans.

Laboratory diagnostics plays a crucial role in diagnosis and treatment paths. Special attention must be paid to the choice of laboratory method, and its execution and dedicated personnel, space, and equipment are indispensable.

This Special Issue aims to collect the most recent knowledge in the field, accepting original research articles and reviews related to coagulation disorders, their molecular mechanisms, diagnostic tests, and novel treatment strategies. 

Dr. Anna Lisa Montemari
Guest Editor

Manuscript Submission Information

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Keywords

  • coagulation
  • bleeding disorders
  • thrombotic mechanisms
  • animal models
  • molecular mechanisms
  • disseminated intravascular coagulation
  • fibrinolysis
  • new diagnostic tools and treatment
  • inflammatory response
  • thrombin generation
  • coagulation alterations induced by hepatic and metabolic disorders
  • drug-induced coagulation alterations

Published Papers (1 paper)

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9 pages, 1187 KiB  
Brief Report
Are Gamers Prone to eThrombosis during Long Gaming Sessions?
by Kasper B. Krarup, Henrik B. Krarup, Morten Mørk, Søren Lundbye-Christensen, Aase Handberg, Hien T. T. Nguyen, Inge S. Pedersen and Søren R. Kristensen
Life 2024, 14(4), 525; https://doi.org/10.3390/life14040525 - 18 Apr 2024
Viewed by 716
Abstract
During the last two decades, several cases of venous thrombosis (VTE) after a prolonged period at a computer have been described, denominated as “eThrombosis”. Video gaming on a computer has become very popular and can be a social activity where several players gather [...] Read more.
During the last two decades, several cases of venous thrombosis (VTE) after a prolonged period at a computer have been described, denominated as “eThrombosis”. Video gaming on a computer has become very popular and can be a social activity where several players gather to play against each other or in a virtual environment for several days (“LAN (i.e., Local Area Network) parties”) where the participants are sedentary and consuming calorie-rich food items. The aim of this study was to investigate potential coagulation activation during a 42 h LAN party. Nine male gamers volunteered for the LAN party. Citrated blood was sampled before and every 6 h, and plasma was analyzed for thrombin generation, thrombin–antithrombin complexes (TAT), prothrombin fragment 1 + 2 (F1 + 2), and D-dimer. Thrombin generation increased slightly but not significantly during the LAN party, whereas the coagulation activation markers were unchanged. These results do not indicate that the coagulation system is activated significantly during 42 h of gaming with minimal physical activity. Although increased activity cannot be excluded, it does not directly indicate a risk of VTE in general. Full article
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