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A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 3687

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Special Issue Editors

Dr. Fabio Maglitto
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Guest Editor

Maxillofaciarl Surgery Operative Unit, Department of Interdisciplinary Medicine, Aldo Moro University of Bari, 70120 Bari, Italy
Interests: oral and maxillofacial surgery; plastic surgery; otolaryngology

Dr. Giovanni Salzano

E-Mail Website
Guest Editor

Maxillofacial Surgery Operative Unit, University Hospital of Naples "Federico II", 80131 Naples, Italy
Interests: oral and maxillofacial surgery; plastic surgery; otolaryngology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, with the rapid development of medical equipment, surgical techniques, and biomaterials, the field of oral and maxillofacial surgery is switching to digital and personalized treatments. This includes digital imaging, digital impressions, jaw modeling, 3D planning of complex oral prosthetics, osteophytes and implant placement, and minimally invasive surgery, such as endoscopic and functional surgery.

This Special Issue, entitled "New Updates in Oral and Maxillofacial Surgery", aims to discuss personalized treatment and future trends in oral and maxillofacial surgery. Therefore, we encourage researchers (clinicians and scientists) in the fields of plastic surgery, oral and maxillofacial surgery, otolaryngology–head and neck surgery, and neurosurgery to submit original articles or reviews to this Special Issue of Journal of Personalized Medicine.

Topics may include (but are not limited to):

Orthognathic surgery, surgical treatment/correction of dental and maxillofacial malformations;
Head and neck cosmetic surgery;
Oral cancer;
Reconstructive surgery;
Management of oral diseases;
New methods and techniques in oral and maxillofacial surgery;
Oral and maxillofacial soft and hard tissue trauma and reconstruction techniques;
Drug-related osteonecrosis of the jaw;
New diagnostic and therapeutic tools for the management of potentially malignant diseases of the oral cavity;
Temporomandibular joint (TMJ) disorders.

Dr. Fabio Maglitto
Dr. Giovanni Salzano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oral and maxillofacial surgery
digital planning
head and neck surgery
reconstructive surgery
implant–prosthetic rehabilitation
oral diseases
regenerative dentistry

Published Papers (4 papers)

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Research

13 pages, 1855 KiB

Open AccessArticle

Assessment of Surgical Accuracy in Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea: A Preliminary Analysis

and

J. Pers. Med. 2023, 13(10), 1517; https://doi.org/10.3390/jpm13101517 - 22 Oct 2023

Viewed by 605

Abstract

This retrospective study aimed to: (1) investigate the surgical accuracy of maxillomandibular advancement (MMA) in obstructive sleep apnea (OSA) patients, with a specific focus on maxillary and mandibular advancement and counter-clockwise rotation and (2) investigate the correlation between the amount of achieved advancement and the reduction in the relative apnea hypopnea index (AHI). Sixteen patients, for whom a three-dimensional virtual surgical plan was generated preoperatively and a computed tomography scan (CT) or cone-beam computer tomography (CBCT) was acquired postoperatively, were included. The postoperative CT or CBCT was compared to the virtual surgical plan, and differences in the mandibular and maxillary advancement and counter-clockwise rotation were assessed. Maxillary and mandibular advancement (median 3.1 mm, p = 0.002 and 2.3 mm, p = 0.03, respectively) and counter-clockwise rotation (median 3.7°, p = 0.006 and 4.7°, p = 0.001, respectively) were notably less than intended. A significant correlation was found between the planned maxillary advancement and the difference between the planned and actual maxillary advancement (p = 0.048; adjusted R² = 0.1979) and also between the planned counter-clockwise rotation and the difference between the planned and actual counter-clockwise rotation for the mandible (p = 0.012; adjusted R² = 0.3261). Neither the maxilla-first nor the mandible-first surgical sequence proved to be superior in terms of the ability to achieve the intended movements (p > 0.45). Despite a significant reduction (p = 0.001) in the apnea hypopnea index (AHI) from a median of 62.6 events/h to 19.4 events/h following MMA, no relationship was found between the extent of maxillary or mandibular advancement and AHI improvement in this small cohort (p = 0.389 and p = 0.387, respectively). This study underlines the necessity for surgeons and future research projects to be aware of surgical inaccuracies in MMA procedures for OSA patients. Additionally, further research is required to investigate if sufficient advancement is an important factor associated with MMA treatment outcome. Full article

(This article belongs to the Special Issue New Updates in Oral and Maxillofacial Surgery)

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10 pages, 4649 KiB

Open AccessArticle

Safety and Aesthetics of Autologous Dermis-Fat Graft after Parotidectomy: A Multidisciplinary Retrospective Study

Ciro Emiliano Boschetti

and

Salvatore Cappabianca

J. Pers. Med. 2023, 13(8), 1200; https://doi.org/10.3390/jpm13081200 - 28 Jul 2023

Viewed by 624

Abstract

(1) Background: In surgical procedures for maxillofacial tumours, it is challenging to preserve functional and cosmetic properties in the affected patients. The use of fat grafting is considered as a valuable alternative to overcome postoperative aesthetic asymmetry problems. (2) Methods: In this study, we enrolled thirty patients with parotid gland tumours in which a partial or complete parotidectomy was performed with positioning in the parotid bed of autologous dermis-fat grafts. We evaluated the satisfaction rate of the patients and the objective efficacy in solving the deformity by comparing MRI data before and after surgery. (3) Results: Twenty-six patients showed a satisfying cosmetic result with proper facial symmetry between the affected side and the healthy one. Two patients presented mild postsurgical complications such as haematomas, and two patients reported temporary weakness of the facial nerve related to the parotidectomy. (4) Conclusions: Based on the imaging data obtained via MRI before and after surgery, we can assess that the employment of fat grafts in parotidectomy surgical procedures gives good cosmetic results and does not affect the post operative management and follow up of oncologic patients. Full article

(This article belongs to the Special Issue New Updates in Oral and Maxillofacial Surgery)

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13 pages, 3570 KiB

Open AccessArticle

Total Joint Replacement for Immediate Reconstruction following Ablative Surgery for Primary Tumors of the Temporo-Mandibular Joint

Luis-Miguel Gonzalez-Perez

Jose-Francisco Montes-Carmona

Eusebio Torres-Carranza

and

Pedro Infante-Cossio

J. Pers. Med. 2023, 13(7), 1021; https://doi.org/10.3390/jpm13071021 - 21 Jun 2023

Cited by 1 | Viewed by 1201

Abstract

Temporomandibular joint (TMJ) tumors are rare and difficult to diagnose. The purpose of this retrospective study was to evaluate the clinicopathologic characteristics of twenty-one patients with primary TMJ tumors between 2010 and 2019 and to analyze the surgical outcome and morbidity after ablative surgery and TMJ replacement. This case series confirmed the difficulty of diagnosis and reaffirmed the need for early recognition and management of TMJ tumors. There were no pathognomonic findings associated with TMJ tumors, although single or multiple radiopaque or radiolucent areas were observed on plain or panoramic radiographs. Occasionally, bone resorption or mottled densities caused by pathologic calcification and ossification were seen. Computed tomography and magnetic resonance imaging played an important role in the diagnosis. In our study, the distribution of histologic types of TMJ tumors was quite different from that of other joint tumors. The recommended treatment was surgical intervention by ablation of the joint and TMJ replacement. The results of this retrospective study support the surgical exeresis and replacement with TMJ stock and custom-made prostheses and show that the approach is efficacious and safe, reduces pain and improves mandibular movements, with few complications. Full article

(This article belongs to the Special Issue New Updates in Oral and Maxillofacial Surgery)

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16 pages, 1231 KiB

Open AccessArticle

Airway Management of Orofacial Infections Originating in the Mandible

Andreas Sakkas

Christel Weiß

Wolfgang Zink

Camila Alejandra Rodriguez

Mario Scheurer

Sebastian Pietzka

Frank Wilde

Oliver Christian Thiele

Robert Andreas Mischkowski

and

Marcel Ebeling

J. Pers. Med. 2023, 13(6), 950; https://doi.org/10.3390/jpm13060950 - 04 Jun 2023

Viewed by 770

Abstract

The primary aim of this study was to assess the incidence of a difficult airway and emergency tracheostomy in patients with orofacial infections originating in the mandible, and a secondary aim was to determine the potential predictors of difficult intubation. This retrospective single-center study included all patients who were referred between 2015 and 2022 with an orofacial infection originating in the mandible and who were surgically drained under intubation anesthesia. The incidence of a difficult airway regarding ventilation, laryngoscopy, and intubation was analyzed descriptively. Associations between potential influencing factors and difficult intubation were examined via multivariable analysis. A total of 361 patients (mean age: 47.7 years) were included in the analysis. A difficult airway was present in 121/361 (33.5%) patients. Difficult intubation was most common in patients with infections of the massetericomandibular space (42.6%), followed by infections of the mouth floor (40%) and pterygomandibular space (23.5%). Dyspnea and stridor were not associated with the localization of infection (p = 0.6486/p = 0.4418). Multivariable analysis revealed increased age, restricted mouth opening, higher Mallampati scores, and higher Cormack–Lehane classification grades as significant predictors of difficult intubation. Higher BMI, dysphagia, dyspnea, stridor and a non-palpable mandibular rim did not influence the airway management. Patients with a difficult airway were more likely to be admitted to the ICU after surgery than patients with regular airway were (p = 0.0001). To conclude, the incidence of a difficult airway was high in patients with orofacial infections originating in the mandible. Older age, limited mouth opening, a higher Mallampati score, and a higher Cormack–Lehane grade were reliable predictors of difficult intubation. Full article

(This article belongs to the Special Issue New Updates in Oral and Maxillofacial Surgery)

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