Endometriosis: Updates on the Etiology, Pathophysiology, Measurements and Therapeutics

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 10 November 2024 | Viewed by 1922

Special Issue Editors


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Guest Editor
Department of Midwifery, University of West Attica, 12243 Athens, Greece
Interests: gynecology; endocrinology; oncology; pharmacology; obstetrics
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Special Issue Information

Dear Colleagues,

The purpose of the Special Issue is to analyse the etiology, pathophysiology, measurements and therapeutics of endometriosis with recent data.

The etiology of endometriosis seems to be related to many factors including transportation of endometrial tissue from the endometrial to the peritoneal cavity in a background of reduced immunity and genetic factors. The pathophysiology of the disease seems to be related to backwards flow of menstruation into the peritoneal cavity through the fallopian tubes in an environment of estrogen dependence. However, it seems that progesterone resistance plays an equally important role in its pathophysiology. Measurements of disease’s severity include its staging according to the revised American Society for Reproductive Medicine scoring system and other staging systems. Therapeutic decisions are related to clinical presentation including severity of pain, extent of the disease, infertility and reproductive desires.

We warmly invite authors to contribute with full-length articles to this Special Issue related to different aspects of endometriosis included in the above topics.

Dr. Georgios M. Iatrakis
Dr. Panagiotis Peitsidis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • etiology
  • pathophysiology
  • measurements
  • therapeutics

Published Papers (1 paper)

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19 pages, 325 KiB  
Review
The Impact of Endometriosis on Pregnancy
by Panagiotis Tsikouras, Efthimios Oikonomou, Anastasia Bothou, Penelopi Chaitidou, Dimitrios Kyriakou, Konstantinos Nikolettos, Sotirios Andreou, Foteini Gaitatzi, Theopi Nalbanti, Panagiotis Peitsidis, Spyridon Michalopoulos, Stefanos Zervoudis, George Iatrakis and Nikolaos Nikolettos
J. Pers. Med. 2024, 14(1), 126; https://doi.org/10.3390/jpm14010126 - 22 Jan 2024
Viewed by 1608
Abstract
Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular dysfunction and low egg quality, as well as luteal phase problems, [...] Read more.
Despite the increased frequency of endometriosis, it remains one of the most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular dysfunction and low egg quality, as well as luteal phase problems, reduced fertilization, and abnormal embryogenesis, are some of the mechanisms advocated to explain reproductive dysfunction. There is a rising need for a comprehensive study of the potential negative consequences of this condition on pregnancy outcomes, including the postpartum period, as more women with a medical history of endometriosis become pregnant. Obstetrical complications (small for gestational age [SGA], cesarean section [CS], miscarriage, hemorrhage, low placental adhesion, and preterm delivery) are statistically elevated in women with endometriosis. Furthermore, ruptured ovarian endometrioma, appendicitis, intestinal perforation, and hemoperitoneum have been described in pregnancy. Obstetricians are largely unfamiliar with these complications, as they have not been thoroughly investigated. The development and pathogenesis of endometriosis is an important field of study and has not yet been fully elucidated. Finding these mechanisms is crucial for the development of new and more effective strategies to treat this condition. Endometriosis can have an impact on obstetric and neonatal outcomes of pregnancy, in addition to its potential effects on conception. To date, no additional monitoring is recommended for pregnancies with a history of endometriosis. However, more studies are urgently needed to assess the need for the tailored pregnancy monitoring of women with endometriosis. Full article
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