Special Issue "The Application of Structural Biology in Antifungal Drug Discovery"
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 24844
Interests: mechanisms of antifungal resistance; structural biology of antifungal targets; antifungal drug discovery; yeast biotechnology
Special Issues, Collections and Topics in MDPI journals
The molecular targets of antifungals in clinical and agricultural use include sterol 14α-demethylase (azoles), squalene monooxygenase/epoxidase (allylamines), β1-3 glucan synthase (echinocandins), ergosterol (polyenes), thymidylate synthase (pyrimidine analogs), succinate dehydrogenase (SDHIs), complex III (Quinone outside Inhibitors), and tubulins (benzimidazoles). Most of the currently marketed antifungals were discovered without knowledge of the 3-dimensional structure of the target molecule and were improved by establishing structure–activity relationships using phenotypic assays and/or target directed biochemical screens. Where target structures were available, identifying antifungal ligands with a suitable clinical window often proved difficult. Recently, high-resolution fungal target enzyme–ligand complexes or complexes with related enzymes have enabled understanding of resistance mechanisms and drug side-effects, helped to improve existing antifungals, and facilitated the identification of novel antifungals using pharmacophore-based discovery or in silico docking with chemically diverse compound libraries and drug-like fragments. This issue will address how approaches that incorporate structural biology are providing new opportunities for antifungal discovery and development.Dr. Brian Monk
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antifungal discovery
- structural biology
- drug target structures