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New Insights into Medically Relevant Fungi
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New Insights into Medically Relevant Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 1074

Special Issue Editor

Prof. Dr. Hector M. Mora-Montes

E-Mail Website
Guest Editor
Department of Biology, Division of Natural Sciences, University of Guanajuato, Guanajuato, Mexico
Interests: fungal cell wall; virulence factors; host–fungus interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue entitled “New Insights into Medically Relevant Fungi” aims to present recent research on any aspect of fungal species that threaten human health. We currently have mycosis caused by well-known etiological agents, diseases caused by emerging fungal pathogens, and diseases associated with fungal species that were previously not recognized as a menace to human beings. Therefore, there is a constant need for new research in both basic and clinical aspects of these pathogens and the caused infections. Some of its focal points include but are not limited to the following:

  1. Host–fungus interaction;
  2. The search for virulence factors;
  3. Fungal sensing by the host immunity;
  4. Epidemiology of mycosis;
  5. Diagnosis of fungal infections;
  6. Use of antifungal drugs and development of new alternatives to control fungal diseases.

Reviews, original research, and communications will be welcome.

Prof. Dr. Hector M. Mora-Montes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

16 pages, 5637 KiB  
Article
Unusual Differences in the Pulmonary Histopathology of Mice after Intranasal Infection with Mycelial Propagules of Histoplasma capsulatum Strains Classified as LAm A2 and NAm 2 Phylogenetic Species
by Evelyn Pulido-Camarillo, Jorge H. Sahaza, Nayla de Souza Pitangui, Maria José S. Mendes-Giannini, Ana M. Fusco-Almeida, Armando Pérez-Torres and Maria Lucia Taylor
J. Fungi 2023, 9(10), 974; https://doi.org/10.3390/jof9100974 - 27 Sep 2023
Viewed by 768
Abstract
The ascomycete Histoplasma capsulatum is the causative agent of systemic respiratory mycosis histoplasmosis, which sometimes develops acute disseminated or chronic clinical forms, with the latter usually associated with granuloma formation. The present report shows differential histopathological changes in the pulmonary inflammatory response of [...] Read more.
The ascomycete Histoplasma capsulatum is the causative agent of systemic respiratory mycosis histoplasmosis, which sometimes develops acute disseminated or chronic clinical forms, with the latter usually associated with granuloma formation. The present report shows differential histopathological changes in the pulmonary inflammatory response of mice infected intranasally with the mycelial morphotype of H. capsulatum strains with distinct genotypes, EH-46 and G-217B, classified as LAm A2 and NAm 2 phylogenetic species, respectively. Infected male BALB/c mice were sacrificed at different postinfection times, and their serial lung sections were stained with periodic acid–Schiff and analyzed via microscopy. In mice infected with the LAm A2 strain, the results showed progressive changes in the inflammatory infiltrate of the lung parenchyma during the first hours and days postinfection as well as granulomas with macrophages containing intracellular yeast cells, which prevailed at 14 and 21 days postinfection. Bronchiolar-associated lymphoid tissue was induced in mice infected with both strains, primarily in mice infected with the NAm 2 strain. Several lung sections from mice infected with the LAm A2 strain showed PAS-positive yeast cells aggregated in a perinuclear crown-like arrangement in macrophages from 3 h to 21 days postinfection. These findings highlight differences in the host pulmonary inflammatory response associated with distinct H. capsulatum species. Full article
(This article belongs to the Special Issue New Insights into Medically Relevant Fungi)
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