Special Issue "Antifungal Susceptibility Testing"
A special issue of Journal of Fungi (ISSN 2309-608X).
Deadline for manuscript submissions: closed (28 February 2017) | Viewed by 39121
Interests: antifungal susceptibility testing; antifungal resistance; medical mycology; taxonomy; diagnosis of fungal infections; epidemiology
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For many years, only one compound was available to treat serious fungal infections. Fortunately, in the last few decades, several other drugs and families have been licenced and, nowadays, there are several therapeutic options to treat patients with these diseases. The number of species able to cause fungal infections has increase exponentially in the last few years. These fungal species have different susceptibility profiles that can vary, even within strains of the same species. In addition, as you might know, antifungal resistance is emerging worldwide in the last years threatening the outcome of patients infected with resistant isolates and becoming a public health threat. This resistance is emerging both in Candida and Aspergillus and in azoles and echinocandins. As a result, knowing the antifungal susceptibility profile and detection of antifungal resistance are essential to manage patients affected with fungal infections. Two organizations: The European, EUCAST and the American, CLSI have intensively worked towards standardized methods for antifungal susceptibility testing and have developed interpretative breakpoints to define antifungal resistance. However, other commercial methods are developed providing comparable results that are increasingly used in the clinical setting. Therefore, nowadays, antifungal susceptibility tests have become essential tools to detect resistance, to guide treatment and to study epidemiology in different settings.
Dr. Ana Alastruey-Izquierdo
Dr. Stéphane Ranque
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