Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.9
4.7
Journals
JoF
Special Issues
Molecular Processes of Fungi, 2nd Edition
share announcement

Molecular Processes of Fungi, 2nd Edition

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1332

Special Issue Editor

Prof. Dr. Willem JG Melchers

E-Mail Website
Guest Editor
Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands
Interests: pathogenesis of Aspergillus; Aspergillus resistance; molecular aspects of resistance; molecular aspects of adaptaton; germination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi are widespread and may cause a wide spectrum of diseases in humans, with infections occurring by, for example, opportunistic pathogens such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans. Fungi can quickly adapt to new and challenging environments in nature, equipping them with intrinsic defenses to overcome cellular stress induced by external stimuli. Adaptation, in this sense, is described as overcoming environmental challenges by gaining beneficial mutations or adjusting cellular physiology. How quickly these adaptations arise and spread after natural selection, depends on forces that drive evolution itself, such as (a)sexual reproduction, ploidy changes, and genetic stability.

A lot of research has been published concerning the clinical aspects of fungal pathogensis, epidemiology, diagnostics, clinical outcome, clinical breakpoints against antifungals, etc. However, the molecular mechanisms of fungal development and growth, stress adaptation and resistance, fungal–host interactions and gene-functions, non-coding RNA functionality, and so on, is still an underexposed field. This Special Issue “Molecular Processes of Fungi” invites colleagues to contribute with original research or reviews to the Journal of Fungi.

Dr. Willem Melchers
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular basis of fungal development and growth
  • stress adaptation and resistance
  • fungal–host interactions and gene-functions
  • non-coding RNA functionality

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1032 KiB  
Article
Aspergillus Outbreak in an Intensive Care Unit: Source Analysis with Whole Genome Sequencing and Short Tandem Repeats
by Stephan J. P. Hiel, Amber C. A. Hendriks, Jos J. A. Eijkenboom, Thijs Bosch, Jordy P. M. Coolen, Willem J. G. Melchers, Paul Anröchte, Simone M. T. Camps, Paul E. Verweij, Jianhua Zhang and Laura van Dommelen
J. Fungi 2024, 10(1), 51; https://doi.org/10.3390/jof10010051 - 06 Jan 2024
Viewed by 1055
Abstract
Whole genome sequencing (WGS) is widely used for outbreak analysis of bacteriology and virology but is scarcely used in mycology. Here, we used WGS for genotyping Aspergillus fumigatus isolates from a potential Aspergillus outbreak in an intensive care unit (ICU) during construction work. [...] Read more.
Whole genome sequencing (WGS) is widely used for outbreak analysis of bacteriology and virology but is scarcely used in mycology. Here, we used WGS for genotyping Aspergillus fumigatus isolates from a potential Aspergillus outbreak in an intensive care unit (ICU) during construction work. After detecting the outbreak, fungal cultures were performed on all surveillance and/or patient respiratory samples. Environmental samples were obtained throughout the ICU. WGS was performed on 30 isolates, of which six patient samples and four environmental samples were related to the outbreak, and twenty samples were unrelated, using the Illumina NextSeq 550. A SNP-based phylogenetic tree was created from outbreak samples and unrelated samples. Comparative analysis (WGS and short tandem repeats (STRs), microsatellite loci analysis) showed that none of the strains were related to each other. The lack of genetic similarity suggests the accumulation of Aspergillus spores in the hospital environment, rather than a single source that supported growth and reproduction of Aspergillus fumigatus. This supports the hypothesis that the Aspergillus outbreak was likely caused by release of Aspergillus fumigatus spores during construction work. Indeed, no new Aspergillus cases were observed in the ICU after cessation of construction. This study demonstrates that WGS is a suitable technique for examining inter-strain relatedness of Aspergillus fumigatus in the setting of an outbreak investigation. Full article
(This article belongs to the Special Issue Molecular Processes of Fungi, 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop