Advanced Functional and Tunable Nano-Systems for High-Performance Theranostic and Tissue Engineering Applications

A special issue of Journal of Nanotheranostics (ISSN 2624-845X).

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 15776

Special Issue Editors


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Guest Editor
Department of Restorative Science, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
Interests: biomaterials; nanomaterials; surface modification; material characterisation; tissue engineering and regenerative medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Developmental and Surgical Sciences, The University of Minnesota, Minneapolis, MN 55455, USA
Interests: nanoparticles; nano/bio-materials; chemical modification; biomedical imaging; cancer targeting; drug delivery; biomedical applications; dental polymers; biodegradable polymers; degradable polymers

Special Issue Information

Dear Colleagues,

Significant advances have been made in the field of nanotechnology, with a spectrum of nanostructures from inorganic to organic nanoformulations being designed for a range of biomedical applications to improve the efficiency and efficacy of the payload. By carefully tuning the chemical makeup of these nanostructures to their shape and size, one can precisely control the biological performance under in vitro and in vivo conditions. Different nanoparticulate systems are being developed to serve as carriers for bioactive payloads, which can then be delivered to the target site, or providing nanoscale topographical cues on the scaffold for mimicking the hierarchical organization of the tissue. The payload carried within these surface-engineered nanoparticle-based formulations ranges from delivering drugs or nucleic acids for disease treatment, antimicrobial agents in order to prevent infection, to growth factors for tissue regeneration. Additionally, significant advances have been made in the design of novel systems for achieving multiple functions such as disease diagnosis and precision therapy via targeted drug delivery systems. Significant efforts are being made on modifying synthesized nano-systems to maximize their therapeutic and diagnostic effects. This includes, but is not limited to, tuning their solubility, toxicity, degradability, cargo release profile, and biodistribution.

This Special Issue is focused on the recent advancements made in developing multifunctional nanoparticulate systems for diagnostic, therapeutic, and tissue engineering applications. We invite authors to submit original research or review articles focusing on the synthesis, surface modification, and biomedical application of nanostructures.

Topics of interest to this Special Issue include, but are not limited to:

  1. Engineering nanoparticle systems for disease targeting, imaging, and/or therapeutics.
  2. Organic or inorganic nanoparticles designed to control cellular response.
  3. Multifaceted bioactive nanostructures with antibacterial and/or immunomodulatory properties.
  4. Responsive nanostructures for tailored release of the payload at the targeted site.
  5. Surface modification strategies to improve nanostructure stability and bioavailability.
  6. Micro/nanoparticle coatings or formulations for disease monitoring, management, and/or treatment.

Dr. Ajeet Kaushik
Dr. Isha Mutreja
Dr. Dhiraj Kumar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Nanotheranostics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • meta nanoparticles
  • polymeric nanoparticles
  • metal oxide nanoparticles
  • surface functionalized
  • organic nanoparticles
  • inorganic nanoparticles
  • targeting
  • molecular delivery
  • drug delivery
  • diagnostics
  • therapeutics
  • nanotherapeutics
  • nano-contrast agents
  • theranostic
  • nanotheranostics
  • cell response
  • tissue engineering
  • cancer
  • bone

Published Papers (5 papers)

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Review

24 pages, 2104 KiB  
Review
Recent Advancement of Bio-Inspired Nanoparticles in Cancer Theragnostic
by Divya Tripathi, Kasturee Hajra and Dipak Maity
J. Nanotheranostics 2023, 4(3), 299-322; https://doi.org/10.3390/jnt4030014 - 24 Jul 2023
Cited by 2 | Viewed by 2586
Abstract
The introduction of cancer therapeutics and nanotechnology has resulted in a paradigm shift from conventional therapy to precision medicine. Nanotechnology, an interdisciplinary field with a focus on biomedical applications, holds immense promise in bringing about novel approaches for cancer detection, diagnosis, and therapy. [...] Read more.
The introduction of cancer therapeutics and nanotechnology has resulted in a paradigm shift from conventional therapy to precision medicine. Nanotechnology, an interdisciplinary field with a focus on biomedical applications, holds immense promise in bringing about novel approaches for cancer detection, diagnosis, and therapy. The past decade has witnessed significant research and material applications related to nanoparticles (NPs). NPs differ from small-molecule drugs as they possess unique physicochemical characteristics, such as a large surface-to-volume ratio, enabling them to penetrate live cells efficiently. Traditional cancer therapies, such as chemotherapy, radiation therapy, targeted therapy, and immunotherapy, have limitations, such as cytotoxicity, lack of specificity, and multiple drug resistance, which pose significant challenges for effective cancer treatment. However, nanomaterials have unique properties that enable new therapeutic modalities beyond conventional drug delivery in the fight against cancer. Moreover, nanoparticles (1–100 nm) have numerous benefits, such as biocompatibility, reduced toxicity, excellent stability, enhanced permeability and retention effect, and precise targeting, making them ideal for cancer treatment. The purpose of this article is to provide consolidated information on various bio-inspired nanoparticles that aid in cancer theranostics. Full article
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21 pages, 7123 KiB  
Review
Recent Advances in Noble Metal Nanoparticles for Cancer Nanotheranostics
by Dhiraj Kumar, Isha Mutreja and Ajeet Kaushik
J. Nanotheranostics 2023, 4(2), 150-170; https://doi.org/10.3390/jnt4020008 - 26 Apr 2023
Cited by 6 | Viewed by 2427
Abstract
The limitations of current treatment strategies for cancer management have prompted a significant shift in the research and development of new effective strategies exhibiting higher efficacy and acceptable side effects. In this direction, nanotheranostics has gained significant interest in recent years, combining the [...] Read more.
The limitations of current treatment strategies for cancer management have prompted a significant shift in the research and development of new effective strategies exhibiting higher efficacy and acceptable side effects. In this direction, nanotheranostics has gained significant interest in recent years, combining the diagnostic and therapeutic capabilities of nanostructures for efficient disease diagnosis, treatment, and management. Such nano-assisted platforms permit the site-specific release of bioactive cargo in a controlled fashion while permitting non-invasive real-time in situ monitoring. A plethora of materials has been developed as pharmacologically relevant nanoformulations for theranostic applications ranging from metallic to lipid and polymer-based composite systems, with each offering potential opportunities and its own limitations. To improve advancements with better clarity, the main focus of this review is to highlight the recent developments focusing on using different noble metal nanoparticles (noble MNPs) as cancer nanotheranostic agents, highlighting their properties, advantages, and potential modifications for their successful utilization in personalized medicine. The advantage of using noble metals (not all, but those with an atomic number ≥76) over metal NPs is their tendency to provide additional properties, such as X-ray attenuation and near-infrared activity. The combination of these properties translates to noble MNPs for therapeutic and diagnostic applications, independent of the need for additional active molecules. Through this review, we highlighted the potential application of all noble MNPs and the limited use of osmium, iridium, palladium, rhodium, and ruthenium metal NSs, even though they express similar physicochemical characteristics. The literature search was limited by PubMed, full-text availability, and studies including both in vitro and in vivo models. Full article
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21 pages, 1562 KiB  
Review
Recent Advancements, Challenges, and Future Prospects in Usage of Nanoformulation as Theranostics in Inflammatory Diseases
by Amit K. Goyal, Manish Ramchandani and Trambak Basak
J. Nanotheranostics 2023, 4(1), 106-126; https://doi.org/10.3390/jnt4010006 - 22 Mar 2023
Cited by 1 | Viewed by 2667
Abstract
As of today, chronic inflammatory diseases are a progressive cause of death worldwide, accounting for more than 50% of all fatalities. These inflammatory conditions are a major concern, ranging from heart disease to cancer, diabetes, to even neurodegenerative conditions. Conventional diagnosis and treatment [...] Read more.
As of today, chronic inflammatory diseases are a progressive cause of death worldwide, accounting for more than 50% of all fatalities. These inflammatory conditions are a major concern, ranging from heart disease to cancer, diabetes, to even neurodegenerative conditions. Conventional diagnosis and treatment for these problems are often challenging and limited due to complex pathophysiology. To improve upon current treatment and diagnostic strategies, theranostic nanomaterials have been developed. Theranostics is an amalgamation of diagnostic biomarkers and therapeutic medicines that have a shared target in damaged cells or tissues. Different theranostic nanoparticles generate enhanced imaging results for facilities such as MRI, PET scan, and CT scans depending on the site of inflammation in different organs. Furthermore, they can be treated with radiopharmaceuticals and/or medicine in nanoparticles. Following a brief discussion of conventional inflammatory diagnosis and therapeutic strategies, this review will cover the recent progress made in theranostic nanomaterials and nanomedicine tactics for managing inflammatory disorders, covering the preclinical and clinical stages of these advances from the past five years. Furthermore, present challenges with theranostic nanoparticles for inflammatory detection and treatment are discussed, as well as future research possibilities. Full article
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31 pages, 5861 KiB  
Review
Responsive Nanostructure for Targeted Drug Delivery
by Vaishali Pawar, Priyanka Maske, Amreen Khan, Arnab Ghosh, Roshan Keshari, Mahek Bhatt and Rohit Srivastava
J. Nanotheranostics 2023, 4(1), 55-85; https://doi.org/10.3390/jnt4010004 - 08 Feb 2023
Cited by 4 | Viewed by 3235
Abstract
Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that responsive biomaterials provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes in the presence of a stimulus, and that stimuli can be temperature, a [...] Read more.
Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that responsive biomaterials provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes in the presence of a stimulus, and that stimuli can be temperature, a magnetic field, ultrasound, pH, humidity, pressure, light, electric field, etc. Different types of stimuli being used in drug delivery shall be explained here. Recent research progress in the design, development and applications of biomaterials comprising responsive nanostructures is also described here. More emphasis will be given on the various nanostructures explored for the smart stimuli responsive drug delivery at the target site such as wound healing, cancer therapy, inflammation, and pain management in order to achieve the improved efficacy and sustainability with the lowest side effects. However, it is still a big challenge to develop well-defined responsive nanostructures with ordered output; thus, challenges faced during the design and development of these nanostructures shall also be included in this article. Clinical perspectives and applicability of the responsive nanostructures in the targeted drug delivery shall be discussed here. Full article
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34 pages, 9783 KiB  
Review
Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges
by Akash Kumar, Nabojit Das and Raja Gopal Rayavarapu
J. Nanotheranostics 2023, 4(1), 1-34; https://doi.org/10.3390/jnt4010001 - 06 Jan 2023
Cited by 5 | Viewed by 3405
Abstract
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development. A superior therapeutic system consists of a multifunctional approach in early diagnosis of the disease with a simultaneous progressive cure, using [...] Read more.
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development. A superior therapeutic system consists of a multifunctional approach in early diagnosis of the disease with a simultaneous progressive cure, using a precise medical approach towards complex treatment. These challenges can be addressed via nanotheranostics and explore suitable approaches to improve health care. Nanotechnology in combination with theranostics as an unconventional platform paved the way for developing novel strategies and modalities leading to diagnosis and therapy for complex disease conditions, ranging from acute to chronic levels. Among the metal nanoparticles, gold nanoparticles are being widely used for theranostics due to their inherent non-toxic nature and plasmonic properties. The unique optical and chemical properties of plasmonic metal nanoparticles along with theranostics have led to a promising era of plausible early detection of disease conditions, and they enable real-time monitoring with enhanced non-invasive or minimally invasive imaging of several ailments. This review aims to highlight the improvement and advancement brought to nanotheranostics by gold nanoparticles in the past decade. The clinical use of the metal nanoparticles in nanotheranostics is explained, along with the future perspectives on addressing the key applications related to diagnostics and therapeutics, respectively. The scope of gold nanoparticles and their realistic potential to design a sophisticated theranostic system is discussed in detail, along with their implications in clinical advancements which are the needs of the hour. The review concluded with the challenges, opportunities, and implications on translational potential of using gold nanoparticles in nanotheranostics. Full article
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