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Biologics and Devices for Periodontal and Peri-Implant Reconstruction
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Biologics and Devices for Periodontal and Peri-Implant Reconstruction

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 3780

Special Issue Editors

Prof. Dr. Mario Taba Jr.

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Guest Editor
School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
Interests: periodontal; regeneration; periodontitis; peri-implantitis; biologic; scaffold
Prof. Dr. Po-Chun Chang

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Guest Editor
Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Interests: tissue engineering; periodontology and implantology; biomaterials; nanotechnology; bioprinting technology; stem cells; clinical trials
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Adrian Kasaj

E-Mail Website
Guest Editor
Department of Periodontology and Operative Dentistry, University Medical Center, Mainz, Germany
Interests: periodontal plastic surgery; periodontal surgery; biomaterials; regenerative periodontal therapy; implants

Special Issue Information

Dear Colleagues,

Tissue reconstruction is a challenging goal. However, as biologics and devices evolve continuously, technological discoveries, innovations, and clinical applications are often at the frontier of knowledge development. In order to keep up with the current advances, this Special Issue, entitled “Biologics and Devices for Periodontal and Peri-Implant Reconstruction”, will present manuscripts related to the developments and usage of biomaterials applied to tissue regeneration, with a focus on soft and hard tissue reconstruction. Topics which will be considered for this Special Issue include, but are not limited to, tissue substitutes, bone substitutes, bioconstructs, biomaterial sciences, bioinks, bioprinting, scaffolds, enriched scaffolds, and biomaterial processing and applications, as well as methods and clinical applications of biologics and devices in animal models and human patients.

We are pleased to invite you to contribute full research papers, review articles, case series, opinions, and communications to this Special Issue.

Prof. Dr. Mario Taba Jr.
Prof. Dr. Po-Chun Chang
Prof. Dr. Adrian Kasaj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone
  • periodontal
  • regeneration
  • periodontitis
  • peri-implantitis
  • biologic
  • scaffold

Published Papers (2 papers)

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Research

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13 pages, 5575 KiB  
Article
Employing Indirect Adenosine 2A Receptors (A2AR) to Enhance Osseointegration of Titanium Devices: A Pre-Clinical Study
by Maria Jesus Pacheco-Vergara, Ernesto Byron Benalcázar-Jalkh, Vasudev V. Nayak, Edmara T. P. Bergamo, Bruce Cronstein, André Luis Zétola, Fernando Pessoa Weiss, João Ricardo Almeida Grossi, Tatiana Miranda Deliberador, Paulo G. Coelho and Lukasz Witek
J. Funct. Biomater. 2023, 14(6), 308; https://doi.org/10.3390/jfb14060308 - 01 Jun 2023
Viewed by 1279
Abstract
The present study aimed to evaluate the effect of dipyridamole, an indirect adenosine 2A receptors (A2AR), on the osseointegration of titanium implants in a large, translational pre-clinical model. Sixty tapered, acid-etched titanium implants, treated with four different coatings ((i) Type I [...] Read more.
The present study aimed to evaluate the effect of dipyridamole, an indirect adenosine 2A receptors (A2AR), on the osseointegration of titanium implants in a large, translational pre-clinical model. Sixty tapered, acid-etched titanium implants, treated with four different coatings ((i) Type I Bovine Collagen (control), (ii) 10 μM dipyridamole (DIPY), (iii) 100 μM DIPY, and (iv) 1000 μM DIPY), were inserted in the vertebral bodies of 15 female sheep (weight ~65 kg). Qualitative and quantitative analysis were performed after 3, 6, and 12 weeks in vivo to assess histological features, and percentages of bone-to-implant contact (%BIC) and bone area fraction occupancy (%BAFO). Data was analyzed using a general linear mixed model analysis with time in vivo and coating as fixed factors. Histomorphometric analysis after 3 weeks in vivo revealed higher BIC for DIPY coated implant groups (10 μM (30.42% ± 10.62), 100 μM (36.41% ± 10.62), and 1000 μM (32.46% ± 10.62)) in comparison to the control group (17.99% ± 5.82). Further, significantly higher BAFO was observed for implants augmented with 1000 μM of DIPY (43.84% ± 9.97) compared to the control group (31.89% ± 5.46). At 6 and 12 weeks, no significant differences were observed among groups. Histological analysis evidenced similar osseointegration features and an intramembranous-type healing pattern for all groups. Qualitative observation corroborated the increased presence of woven bone formation in intimate contact with the surface of the implant and within the threads at 3 weeks with increased concentrations of DIPY. Coating the implant surface with dipyridamole yielded a favorable effect with regard to BIC and BAFO at 3 weeks in vivo. These findings suggest a positive effect of DIPY on the early stages of osseointegration. Full article
(This article belongs to the Special Issue Biologics and Devices for Periodontal and Peri-Implant Reconstruction)
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Review

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28 pages, 2015 KiB  
Review
Three-Dimensional Printing Methods for Bioceramic-Based Scaffold Fabrication for Craniomaxillofacial Bone Tissue Engineering
by Zeeshan Sheikh, Vasudev Vivekanand Nayak, Umer Daood, Anupreet Kaur, Hanan Moussa, Abbas Canteenwala, Pierre-Luc Michaud, Ísis de Fátima Balderrama, Edisa de Oliveira Sousa, Nick Tovar, Andrea Torroni, Michael Glogauer, Huzefa Talib, Paulo G. Coelho and Lukasz Witek
J. Funct. Biomater. 2024, 15(3), 60; https://doi.org/10.3390/jfb15030060 - 01 Mar 2024
Viewed by 2016
Abstract
Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their [...] Read more.
Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and an increased risk of implant failure. To address these challenges, researchers have been developing strategies to improve the biological performance of 3D-printed bioceramic implants. The purpose of this review is to provide an overview of 3DP techniques and strategies for bioceramic materials designed for bone regeneration. The review also addresses the use and incorporation of active biomolecules in 3D-printed bioceramic constructs to stimulate bone regeneration. By controlling the surface roughness and chemical composition of the implant, the construct can be tailored to promote osseointegration and reduce the risk of adverse tissue reactions. Additionally, growth factors, such as bone morphogenic proteins (rhBMP-2) and pharmacologic agent (dipyridamole), can be incorporated to promote the growth of new bone tissue. Incorporating porosity into bioceramic constructs can improve bone tissue formation and the overall biological response of the implant. As such, employing surface modification, combining with other materials, and incorporating the 3DP workflow can lead to better patient healing outcomes. Full article
(This article belongs to the Special Issue Biologics and Devices for Periodontal and Peri-Implant Reconstruction)
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