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Molecular and Cellular Mechanisms in Vestibular Disorders
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Molecular and Cellular Mechanisms in Vestibular Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 4796

Special Issue Editor

Dr. Christian Chabbert

E-Mail Website
Guest Editor
Team Pathophysiology and Therapy of Vestibular Disorders, Laboratory of Cognitive Neurosciences, UMR7291, Aix Marseille University-CNRS, CEDEX 07, 13007 Marseille, France
Interests: vestibular disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of therapeutic approaches against vestibular disorders remains considerably hampered by the lack of knowledge on the molecular and cellular mechanisms that support these pathologies. However, the recent application to the vestibular neuro-otology field of innovative technological approaches now allows us to better understand the etiology of these pathologies and to anticipate more targeted and more effective pharmacological actions. This Special Issue aims to bring together fundamental and clinical studies, as well as reviews illustrating the different current approaches in the field.

JCM is pleased to announce that we will be publishing a Special Issue on the theme of “Molecular and Cellular Mechanisms in Vestibular Disorders”. A special discount will be applied to up to 10 participants, whose papers will be published free of charge.

I therefore invite you to join us by contributing an article of your choice for this Special Issue, whose deadline is 15 August 2023.

You may choose our Joint Special Issue in Biomolecules.

Dr. Christian Chabbert
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vestibular disorders
  • cellular and molecular mechanisms
  • pharmacology
  • imaging

Published Papers (5 papers)

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Research

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20 pages, 2760 KiB  
Article
Identification of Follow-Up Markers for Rehabilitation Management in Patients with Vestibular Schwannoma
by Frédéric Xavier, Emmanuelle Chouin, Brahim Tighilet, Jean-Pierre Lavieille and Christian Chabbert
J. Clin. Med. 2023, 12(18), 5947; https://doi.org/10.3390/jcm12185947 - 13 Sep 2023
Viewed by 653
Abstract
This study delves into the absence of prognostic or predictive markers to guide rehabilitation in patients afflicted with vestibular schwannomas. The objective is to analyze the reweighting of subjective and instrumental indicators following surgery, at 7 days and 1 month postoperatively. This retrospective [...] Read more.
This study delves into the absence of prognostic or predictive markers to guide rehabilitation in patients afflicted with vestibular schwannomas. The objective is to analyze the reweighting of subjective and instrumental indicators following surgery, at 7 days and 1 month postoperatively. This retrospective cohort encompasses 32 patients who underwent unilateral vestibular schwannoma surgery at the Marseille University Hospital between 2014 and 2019. Variations in 54 indicators and their adherence to available norms are calculated. After 1 month, one-third of patients do not regain the norm for all indicators. However, the rates of variation unveil specific responses linked to a preoperative error signal, stemming from years of tumor adaptation. This adaptation is reflected in a postoperative visual or proprioceptive preference for certain patients. Further studies are needed to clarify error signals according to lesion types. The approach based on variations in normative indicators appears relevant for post-surgical monitoring and physiotherapy. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Vestibular Disorders)
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9 pages, 289 KiB  
Article
Chronic Vestibular Hypofunction Is Associated with Impaired Sleep: Results from the DizzyReg Patient Registry
by Benedict Katzenberger, Fiona Brosch, Stéphane Besnard and Eva Grill
J. Clin. Med. 2023, 12(18), 5903; https://doi.org/10.3390/jcm12185903 - 11 Sep 2023
Cited by 2 | Viewed by 1245
Abstract
Temporary or permanent vestibular hypofunction has been hypothesized to affect circadian rhythm, sleep, and thermoregulation. Chronic or long-term vestibular disorders such as unilateral vestibular hypofunction may have an even greater negative impact on sleep quality than acute vestibular problems. This study examines self-reported [...] Read more.
Temporary or permanent vestibular hypofunction has been hypothesized to affect circadian rhythm, sleep, and thermoregulation. Chronic or long-term vestibular disorders such as unilateral vestibular hypofunction may have an even greater negative impact on sleep quality than acute vestibular problems. This study examines self-reported sleep quality, as assessed by the Pittsburgh Sleep Quality Index (PSQI), and its association with vestibular symptom duration in a group of patients with vestibular disorders. We used data from the cross-sectional DizzyReg patient registry of the German Center for Vertigo and Balance Disorders outpatient clinic. Vestibular diagnoses were ascertained based on the International Classification of Vestibular Disorders. A total of 137 patients were included (60% female, mean age 55.4 years, standard deviation, SD, 16.7). The mean PSQI total score was 6.3 (SD = 3.2), with 51% reporting overall poor sleep quality. Patients who had vertigo for two years or longer reported significantly poorer global sleep quality (63% vs. 37%, p = 0.021) and significantly more difficulties with sleep latency (79% vs. 56%, p = 0.013) and sleep efficiency (56% vs. 34%, p = 0.022). The association of poor sleep quality with a longer duration of vertigo remained significant after multivariable adjustment. Further research should investigate the interaction of vestibular disorders, sleep, and their potential mechanisms. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Vestibular Disorders)
14 pages, 2105 KiB  
Article
How a Subclinical Unilateral Vestibular Signal Improves Binocular Vision
by Frédéric Xavier, Emmanuelle Chouin, Véronique Serin-Brackman and Alexandra Séverac Cauquil
J. Clin. Med. 2023, 12(18), 5847; https://doi.org/10.3390/jcm12185847 - 08 Sep 2023
Viewed by 773
Abstract
The present study aimed to determine if an infra-liminal asymmetric vestibular signal could account for some of the visual complaints commonly encountered in chronic vestibular patients. We used infra-liminal galvanic vestibular stimulation (GVS) to investigate its potential effects on visuo-oculomotor behavior. A total [...] Read more.
The present study aimed to determine if an infra-liminal asymmetric vestibular signal could account for some of the visual complaints commonly encountered in chronic vestibular patients. We used infra-liminal galvanic vestibular stimulation (GVS) to investigate its potential effects on visuo-oculomotor behavior. A total of 78 healthy volunteers, 34 aged from 20 to 25 years old and 44 aged from 40 to 60 years old, were included in a crossover study to assess the impact of infra-liminal stimulation on convergence, divergence, proximal convergence point, and stereopsis. Under GVS stimulation, a repeated measures ANOVA showed a significant variation in near convergence (p < 0.001), far convergence (p < 0.001), and far divergence (p = 0.052). We also observed an unexpected effect of instantaneous blocking of the retest effect on the far divergence measurement. Further investigations are necessary to establish causal relationships, but GVS could be considered a behavioral modulator in non-pharmacological vestibular therapies. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Vestibular Disorders)
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9 pages, 921 KiB  
Article
Infliximab for the Treatment of Inflammatory Labyrinthitis: A Retrospective Cohort Study
by Cassandre Djian, Karine Champion, Nicolas Lai, Ludovic Drouet, Blanca Amador Borrero, Audrey Depond, Stéphane Mouly, Clément Jourdaine, Philippe Herman, Michael Eliezer, Charlotte Hautefort and Damien Sène
J. Clin. Med. 2023, 12(13), 4350; https://doi.org/10.3390/jcm12134350 - 28 Jun 2023
Viewed by 832
Abstract
Inflammatory labyrinthitis is defined as a fluctuant vestibulo-cochlear syndrome associated with an impairment of the blood-labyrinthine barrier (BLB) on delayed FLAIR MRI sequences. Systemic and intratympanic corticosteroids are the gold standard treatment but their effect is frequently insufficient. The objective is here to [...] Read more.
Inflammatory labyrinthitis is defined as a fluctuant vestibulo-cochlear syndrome associated with an impairment of the blood-labyrinthine barrier (BLB) on delayed FLAIR MRI sequences. Systemic and intratympanic corticosteroids are the gold standard treatment but their effect is frequently insufficient. The objective is here to determine whether infliximab could be of value in the treatment of bilateral inflammatory labyrinthitis. A retrospective monocentric study was conducted between January 2013 and December 2021. All patients included in the study were affected with a bilateral vestibulo-cochlear syndrome associated with bilateral blood-labyrinthine barrier impairment. Patients were administered infliximab at the dose of 5 mg/kg every 6 weeks for 6 months. Audiometry, MRI with delayed FLAIR sequences on the labyrinth, and corticosteroid doses still required were assessed both before and after treatment with infliximab was completed. Pure-tone average (PTA) was the primary outcome. The secondary outcomes were the speech recognition threshold (SRT), the Dizziness Handicap Inventory (DHI) score, and the corticosteroid (CS) dose. A total of nine patients including five men and four women were enrolled in the study. Thirteen ears were analyzed. After a 6-month period of treatment, the mean PTA (54 ± 24 db versus 66 ± 22 db; p = 0.027), SRT (54 ± 37 db versus 66 ± 32 db; p = 0.041) and DHI score (27 ± 15 versus 9 ± 2; p = 0.032) significantly improved. After the 6-month treatment period, the mean CS dose decreased from 38 ± 33 to 6 ± 5 mg/day (p = 0.003). We conclude that infliximab substantially improves the vestibulo-cochlear function in patients with bilateral inflammatory labyrinthitis and could be of value in corticosteroid-dependent cases. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Vestibular Disorders)
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Review

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11 pages, 34977 KiB  
Review
Cochleo-Vestibular Disorders in Herpes Zoster Oticus: A Literature Review and a Case of Bilateral Vestibular Hypofunction in Unilateral HZO
by Roberto Teggi, Anna Del Poggio, Iacopo Cangiano, Alessandro Nobile, Omar Gatti and Mario Bussi
J. Clin. Med. 2023, 12(19), 6206; https://doi.org/10.3390/jcm12196206 - 26 Sep 2023
Viewed by 1090
Abstract
The varicella-zoster virus (VZV), a member of the Herpesviridae family, causes both the initial varicella infection and subsequent zoster episodes. Disorders of the eighth cranial nerve are common in people with herpes zoster oticus (HZO). We performed a review of the literature on [...] Read more.
The varicella-zoster virus (VZV), a member of the Herpesviridae family, causes both the initial varicella infection and subsequent zoster episodes. Disorders of the eighth cranial nerve are common in people with herpes zoster oticus (HZO). We performed a review of the literature on different databases including PubMed and SCOPUS, focusing on cochlear and vestibular symptoms; 38 studies were considered in our review. A high percentage of cases of HZO provokes cochlear and vestibular symptoms, hearing loss and vertigo, whose onset is normally preceded by vesicles on the external ear. It is still under debate if the sites of damage are the inferior/superior vestibular nerves and cochlear nerves or a direct localization of the infection in the inner ear. The involvement of other contiguous cranial nerves has also been reported in a few cases. We report the case of a patient with single-side HZO presenting clinical manifestations of cochleo-vestibular damage without neurological and meningeal signs; after 15 days, the patient developed a new episode of vertigo with clinical findings of acute contralateral vestibular loss. To our knowledge, only three other such cases have been published. An autoimmune etiology may be considered to explain these findings. Full article
(This article belongs to the Special Issue Molecular and Cellular Mechanisms in Vestibular Disorders)
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