New Insights into Corneal Regeneration and Transplantation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 960

Special Issue Editors


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Guest Editor
Eye Hospital, Ljubljana University Medical Centre, Ljubljana, Slovenia
Interests: cornea; corneal surface disease; corneal transplantation; eye banking; corneal stem cells; corneal immunology

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Guest Editor
1. Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
2. Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
3. Discipline of Ophthalmology and Visual Sciences, Faculty of Health and Medical Sciences, Adelaide Medical School, University of Adelaide, Adelaide, Australia
Interests: cornea; dry eye disease; corneal transplantation; corneal regeneration; epidemiology
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Special Issue Information

Dear Colleagues,

We are delighted to announce the launch of our upcoming Special Issue ‘New Insights into Corneal Regeneration and Transplantation’, which will feature in the Journal of Clinical Medicine. The cornea, as a vital ocular structure, plays an irreplaceable role in maintaining visual acuity and overall eye health. However, its susceptibility to injury, disease, and degeneration necessitates an in-depth understanding of regenerative therapies and transplantation techniques.

This Special Issue invites contributions from scientists, clinicians and leading experts in the fields of ophthalmology, eye banking, and transplantation, who have conducted pioneering and well-founded research on the intricacies of corneal regeneration and transplantation. Through a multidisciplinary lens, this Special Issue will ensure to provide insights into a wide array of the latest innovative strategies, such as stem cell therapies, tissue-engineered constructs, and immunomodulatory interventions, that have revolutionized the practical applications of corneal treatments. Moreover, we also aim to include studies addressing the challenges of immune rejection, graft survival, and functional restoration, thereby heralding a new era of precision medicine in ocular care.

We sincerely hope that this Special Issue will not only strengthen the knowledge of current advancements in ocular care but also pave the way for novel explorations, fostering improved clinical outcomes and an enhanced quality of life for countless individuals.

Dr. Zala Lužnik Marzidovšek
Dr. Rohan Bir Singh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cornea
  • corneal surface disease
  • corneal transplantation
  • eye banking
  • corneal stem cells
  • corneal immunology

Published Papers (1 paper)

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Research

12 pages, 400 KiB  
Article
Risk Factors for Corneal Endothelial Decompensation after Penetrating Keratoplasty: A Population-Based Cohort Study
by Hung-Chi Chen, Chia-Yi Lee, Yu-Ling Chang, Jing-Yang Huang, Shun-Fa Yang and Chao-Kai Chang
J. Clin. Med. 2024, 13(3), 718; https://doi.org/10.3390/jcm13030718 - 26 Jan 2024
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Abstract
(1) Background: Endothelial decompensation is a common complication after penetrating keratopathy (PK), while the risk factors for endothelial decompensation after PK have not been fully elucidated. Consequently, we aim to investigate the possible risk factors for endothelial decompensation after PK. (2) Methods: This [...] Read more.
(1) Background: Endothelial decompensation is a common complication after penetrating keratopathy (PK), while the risk factors for endothelial decompensation after PK have not been fully elucidated. Consequently, we aim to investigate the possible risk factors for endothelial decompensation after PK. (2) Methods: This retrospective study was conducted using the National Health Insurance Research Database (NHIRD) of Taiwan. The main outcome was the development of endothelial decompensation after PK surgery. The effects of potential risk factors were compared between the patients with endothelial decompensation and the patients without endothelial decompensation via Cox proportional hazard regression, which produced the adjusted hazard ratio (aHR) and a 95% confidence interval (CI). (3) Results: Overall, 54 patients developed endothelial decompensation after PK surgery, with a ratio of 16.12 percent. The pre-existing type 2 diabetes mellitus (T2DM) (aHR: 1.924, 95% CI: 1.257–2.533, p = 0.0095) and history of cataract surgery (aHR: 1.687, 95% CI: 1.328–2.440, p = 0.0026) were correlated with the development of endothelial decompensation. In the subgroup analysis, the correlation between a history of cataract surgery and post-PK endothelial decompensation was more prominent in patients older than 60 years compared to their younger counterparts (p = 0.0038). (4) Conclusions: Pre-existing T2DM and a history of cataract surgery are associated with a higher incidence of post-PK endothelial decompensation. Full article
(This article belongs to the Special Issue New Insights into Corneal Regeneration and Transplantation)
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