Regeneration of Chronic Tympanic Membrane Perforations: Treatments, Challenges and Emerging Therapeutics

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 4296

Special Issue Editors


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Guest Editor
1. Department of Otolaryngology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea
2. Department of Otolaryngology, Gwangju Veterans Hospital, Gwangju 62284, Republic of Korea
Interests: tinnitus; facial nerve regeneration; tissue engineering & regeneration
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Guest Editor
Department of Biology, College of Natural Sciences, Chosun University, Gwangju 61452, Korea
Interests: regeneration; tympanic membrane; Stem cells; aging; epigenetics

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Guest Editor
Department of Otolaryngology, Cathay General Hospital, Taipei, Taiwan
Interests: otolaryngology; regeneration; tympanic membrane perforation

Special Issue Information

Dear Colleagues,

To date, regeneration of chronic tympanic membrane perforations is considered standard care in patients with chronic otitis media (COM). Over the past few years, the development of new technologies such as tissue engineering, 3D printing, and bioprinting have been shown to result in better outcomes in terms of regeneration research. This has resulted in the use of a variety of scaffolds, stem cells, bioactive molecules, imaging modalities, and acousticomechanical analysis.

So far, the majority of studies have been limited to the research field. The number of clinical indications in which the tissue engineering approach is applied keeps expanding.  

This Special Issue of the Journal of Clinical Medicine will provide the current trends in regeneration of chronic tympanic membrane perforations.

Prof. Dr. Chul Ho Jang
Prof. Dr. Gwang-Won Cho
Prof. Dr. PaChun Wang
Guest Editors

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Keywords

  • regeneration
  • tympanic membrane perforation
  • tissue engineering
  • new scaffold

Published Papers (1 paper)

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Research

16 pages, 2580 KiB  
Article
Effect of Growth Factor-Loaded Acellular Dermal Matrix/MSCs on Regeneration of Chronic Tympanic Membrane Perforations in Rats
by Gwang-Won Cho, Changjong Moon, Anji Song, Karthikeyan A. Vijayakumar, Mary Jasmin Ang and Chul Ho Jang
J. Clin. Med. 2021, 10(7), 1541; https://doi.org/10.3390/jcm10071541 - 06 Apr 2021
Cited by 7 | Viewed by 3254
Abstract
The success rate of grafting using acellular dermal matrix (ADM) for chronic tympanic membrane was reported in previous studies to be lower than fascia or perichondrium. Combining mesenchymal stem cells (MSCs) and growth factor-loaded ADM for the regeneration of chronic TMP has not [...] Read more.
The success rate of grafting using acellular dermal matrix (ADM) for chronic tympanic membrane was reported in previous studies to be lower than fascia or perichondrium. Combining mesenchymal stem cells (MSCs) and growth factor-loaded ADM for the regeneration of chronic TMP has not been reported so far. In this study, we hypothesized that combining growth factor-loaded ADM/MSCs could promote the recruitment of MSCs and assist in TMP regeneration. We evaluated the regeneration and compared the performance of four scaffolds in both in vitro and in vivo studies. MTT, qPCR, and immunoblotting were performed with MSCs. In vivo study was conducted in 4 groups (control; ADM only, ADM/MSC, ADM/MSC/bFGF, ADM/MSC/EGF) of rats and inferences were made by otoendoscopy and histological changes. Attachment of MSCs on ADM was observed by confocal microscopy. Proliferation rate increased with time in all treated cells. Regeneration-related gene expression in the treated groups was higher. Also, graft success rate was significantly higher in ADM/MSC/EGF group than other groups. Significant relationships were disclosed in neodrum thickness between each group. The results suggest, in future, combining EGF with ADM/MSCs could possibly be used as an outpatient treatment, without the need for surgery for eardrum regeneration. Full article
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