Dear Colleagues,

Liver transplantation is a life-saving procedure for patients with end-stage liver disease and several malignancies. Over the years, significant advancements have been made in liver transplantation, leading to improved outcomes and expanded eligibility criteria. In terms of current management, the success of liver transplantation relies on several key factors. These include appropriate donor selection, meticulous surgical techniques, tailored immunosuppressive regimens, and comprehensive post-transplant care. Organ allocation systems have evolved to prioritize patients based on the severity of illness, ensuring the equitable distribution of available organs. Surgical approaches have become more refined, with advancements such as living donor liver transplantation and split liver transplantation expanding the donor pool and reducing waiting times. Improved immunosuppressive medications and protocols have improved long-term graft and patient survival rates. Moreover, multidisciplinary care teams comprising hepatologists, transplant surgeons, anesthesiologists, and other specialists work collaboratively to optimize pre-and post-transplant care, including managing complications. Several future options show promise for further enhancing liver transplantation. Advancements in organ preservation techniques, such as machine perfusion, may allow for longer preservation times, reducing organ shortages and improving outcomes. The development of artificial liver devices holds the potential to bridge the gap between transplantation and organ regeneration. Additionally, advances in genomics and precision medicine may enable personalized immunosuppressive strategies, minimizing complications and improving long-term graft survival. Gene-editing technologies, such as CRISPR-Cas9, can modify donor organs in order to mitigate immunological barriers and improve compatibility. Liver transplantion continues to evolve, with future options that hold the potential to further revolutionize the field. Continued research and innovation in liver transplantation are essential in order to overcome challenges, enhance patient care, and save more lives. Therefore, researchers in liver transplantation are encouraged to submit their findings as original articles or reviews to this Special Issue.

Prof. Dr. Salvatore Agnes
Dr. Francesco Giovinazzo
Guest Editors

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• liver transplantation
• immunosuppressive regimens
• organ allocation and donor selection
• living donor liver transplantation
• split liver transplantation
• multidisciplinary care
• machine perfusion
• artificial liver devices
• gene-editing technologies