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Clinical Advances in Interstitial Lung Diseases
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Clinical Advances in Interstitial Lung Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 1636

Special Issue Editors

Dr. Yoshiaki Zaizen

E-Mail Website
Guest Editor
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
Interests: interstitial lung diseases; pulmonary medicine; diffuse lung disease; lung diseases; pulmonary fibrosis; tuberculosis
Special Issues, Collections and Topics in MDPI journals
Dr. Masaki Okamoto

E-Mail Website
Guest Editor
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
Interests: respirology; diffuse lung disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of interstitial lung disease has experienced significant progress over the past decade. The cryobiopsy method has been established as a method for obtaining tissue samples for the pathology. With the improvement of analysis technology using artificial intelligence, there have also been remarkable developments in genome classification. In pharmacological therapy, two antifibrotic agents, pirfenidone and nintedanib, have provided alternatives to conventional corticosteroid-based anti-inflammatory therapy and are effective in the treatment of idiopathic and progressive pulmonary fibrosis. Additionally, today, many compounds with antifibrotic activity are in development. Scientific evidence is also slowly but surely establishing non-pharmacological therapies, such as respiratory rehabilitation. We now need to understand the pathophysiology and prognoses of patients with interstitial lung disease and provide appropriate treatment and management.

In this Special Issue, we welcome authors to submit papers that will provide more reliable evidence of the advances in the diagnosis and treatment of interstitial lung disease.

You may choose our Joint Special Issue in Medicina.

Dr. Yoshiaki Zaizen
Dr. Masaki Okamoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interstitial lung disease
  • idiopathic interstitial pneumonias
  • idiopathic pulmonary fibrosis
  • hypersensitivity pneumonitis
  • connective tissue disease-associated interstitial lung disease
  • diagnosis
  • treatment

Published Papers (2 papers)

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Research

12 pages, 1784 KiB  
Article
Usefulness of Combined Measurement of Surfactant Protein D, Thrombin–Antithrombin III Complex, D-Dimer, and Plasmin–α2 Plasmin Inhibitor Complex in Acute Exacerbation of Interstitial Lung Disease: A Retrospective Cohort Study
by Yuichiro Takeshita, Masako To, Yusuke Kurosawa, Naho Furusho, Toru Kinouchi, Kenji Tsushima, Yuji Tada, Yasuo To and Seiichiro Sakao
J. Clin. Med. 2024, 13(8), 2427; https://doi.org/10.3390/jcm13082427 - 21 Apr 2024
Viewed by 306
Abstract
Background/Objectives: The coagulation cascade due to tissue damage is considered to be one of the causes of poor prognostic outcomes in patients with acute exacerbations of interstitial lung disease (AE-ILD). This study aimed to confirm coagulopathy in AE-ILD by evaluating the differences [...] Read more.
Background/Objectives: The coagulation cascade due to tissue damage is considered to be one of the causes of poor prognostic outcomes in patients with acute exacerbations of interstitial lung disease (AE-ILD). This study aimed to confirm coagulopathy in AE-ILD by evaluating the differences in the clinical characteristics of coagulation/fibrinolysis markers between stable ILD and AE-ILD. Methods: Overall, 81 patients were enrolled in this retrospective study and categorized into the following two groups: a chronic ILD group comprising 63 outpatients and an acute ILD group comprising 18 inpatients diagnosed with AE-ILD. Serum markers, including thrombin–antithrombin III complex (TAT), D-dimer, plasmin–α2 plasmin inhibitor complex (PIC), and surfactant protein D (SP-D), were compared between the groups. Results: Among the 18 patients with acute ILD, 17 did not meet the International Society of Thrombosis and Hemostasis scoring system for disseminated intravascular coagulation. In acute ILD, the SP-D levels were statistically significantly positively correlated with TAT, D-dimer, and PIC levels, while the Krebs von den Lungen 6 (KL-6) levels showed no correlation with any of these coagulation/fibrinolytic markers. A positive correlation was observed between SP-D levels and TAT, D-dimer, and PIC levels in acute ILD. Serum TAT, D-dimer, and PIC all showed good area under the receiver operating characteristic (ROC) curve (AUC) values in ROC analysis for the diagnosis of acute ILD. Conclusions: In the clinical setting of AE-ILD, it may be important to focus not only on alveolar damage markers such as SP-D but also on coagulation/fibrinolytic markers including TAT, D-dimer, and PIC. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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14 pages, 1493 KiB  
Article
Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease
by Goushi Matama, Masaki Okamoto, Kiminori Fujimoto, Takeshi Johkoh, Masaki Tominaga, Hiroshi Mukae, Noriho Sakamoto, Kosaku Komiya, Kenji Umeki, Masamichi Komatsu, Yasuo Shimizu, Koichiro Takahashi, Saeko Tokisawa, Yoshiaki Zaizen, Norikazu Matsuo, Takashi Nouno, Shinjiro Kaieda, Hiroaki Ida, Kenji Izuhara and Tomoaki Hoshino
J. Clin. Med. 2023, 12(22), 7100; https://doi.org/10.3390/jcm12227100 - 15 Nov 2023
Viewed by 1058
Abstract
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without [...] Read more.
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), and lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without ILD, and 137 healthy controls (HC). All biomarkers were higher in RA-ILD than HC or RA without ILD. KL-6 accurately detected ILD in RA patients (area under curve [AUC] = 0.939) and moderately detected SP-D and monomeric and total periostin (AUC = 0.803, =0.767, =0.767, respectively). Monomeric and total periostin were negatively correlated with normal lung area and positively correlated with honeycombing, reticulation, fibrosis score, and the traction bronchiectasis grade but not inflammatory areas. Serum levels of SP-D, KL-6, and LDH did not correlate with the extent of those fibrotic areas on high-resolution CT. Serum monomeric and total periostin were higher in patients with RA-ILD with definite usual interstitial pneumonia pattern compared with other ILD patterns. Immunohistochemical analyses of biopsy or autopsy lung tissues from RA-ILD during the chronic phase and acute exacerbation showed that periostin was expressed in fibroblastic foci but not inflammatory or dense fibrosis lesions. Periostin is a potential biomarker for diagnosis, evaluating fibrosis, and deciding therapeutic strategies for patients with RA-ILD. Full article
(This article belongs to the Special Issue Clinical Advances in Interstitial Lung Diseases)
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