Pathogenesis of the Homeostatic Failure of Ocular Surface as Morpho-Functional Unit—Volume II
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".
Deadline for manuscript submissions: closed (25 November 2023) | Viewed by 180
Special Issue Editor
Interests: cornea; corneal transplantation; dry eye disease; allergy; corneal angiogenesis; immunology; refractive surgery; stem cell transplantation; keratoprosthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In July 2020, the first volume of the Special Issue “Pathogenesis of the Homeostatic Failure of Ocular Surface as Morpho-Functional Unit” was launched (https://www.mdpi.com/journal/jcm/special_issues/ocular_surface). We received many excellent papers on topic of ocular surface and its diseases. Now, we would like to launch the second volume on this topic.
The ocular surface is a complex, morpho-functional unit in which multiple anatomical and cellular components (cornea, conjunctivae, lacrimal glands, Meibomian glands, tear film, immune cells and nervous fibers) cooperate to preserve homeostasis. This equilibrium promotes the repair of the ocular surface following daily repetitive insults. Self-limiting innate immune mechanisms maintain and restore homeostasis and permit tissues to adapt to injuries and restore their normal functions. However, if dysregulated, it may trigger overt inflammation, resulting in the clinical signs observed in several ocular chronic disorders.
Such a dysfunction may possibly be due to neurogenic, immune, metabolic and hormonal alterations which dysregulate the normal healthy equilibrium. In such patients, the dysregulated inflammatory response is not self-limiting but persistent, leading to a critical shift in homeostatic baseline towards inflammation with changes in immune-responsiveness and vulnerability to illness, underlining the loss of the homeostatic ability of ocular surface, as in other conditions, such as ageing.
The aim of this Special Issue is to investigate clinical and molecular inflammatory changes at the ocular surface in several ocular surface diseases in which such homeostatic mechanisms are dysregulated, showing persistent chronic, subclinical or excessive inflammatory response despite the insult.
Dr. Antonio Di Zazzo
Guest Editor
Manuscript Submission Information
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Keywords
- dry eye disease
- ocular surface diseases
- ageing
- allergy
- chronic cicatrizing conjunctivitis
- ocular surface diabetic disease
- polycystic ovary syndrome
