Clinical Advances in Pulmonary Heart Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 485

Special Issue Editors


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Guest Editor
1. First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, Greece
2. National Pulmonary Hypertension Service, Royal Brompton Hospital, London SW3 6NP, UK
Interests: pulmonary hypertension; congenital heart disease; artificial intelligence
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Guest Editor
National Pulmonary Hypertension Service, Royal Brompton Hospital, London SW3 6NP, UK
Interests: lung disease; interstitial lung disease; pulmonary hypertension

Special Issue Information

Dear Colleagues, 

Pulmonary hypertension (PH) represents a rare and heterogeneous group of pulmonary vasculopathies defined by elevated mean pulmonary arterial pressure and pulmonary vascular resistance that leads progressively to right heart failure and premature death, if not early diagnosed and promptly treated. PH is haemodynamically defined as a mean pulmonary artery pressure > 20 mmHg and is classified into five distinct groups, taking into account the underlying condition, clinical and haemodynamic features PH can be attributed to a wide spectrum of underlying conditions, such as left heart disease, lung disease, pulmonary artery obstruction, but it can also be associated with drugs and toxins, connective tissue disease (CTD-PAH), HIV infection, portal hypertension (portal-PAH), congenital heart disease (CHD-PAH) and schistosomiasis or it can be idiopathic (IPAH) or heritable (HPAH). In the past 30 years, there was an increased research interest in the field of pathophysiology, diagnosis and targeted pulmonary arterial hypertension (PAH) therapies. New diagnostic modalities and algorithms were employed to detect PH early, while new drugs have been developed that target different pathophysiologic pathways aiming to increase life expectancy. In this Special Issue, we would like to invite original clinical and basic research, meta-analyses, and state-of-the-art reviews related to clinical advances in the whole spectrum of PH and pulmonary heart disease in general. We will be grateful to receive your submissions to move the field of PH forward.

Dr. Alexandra D. Arvanitaki
Dr. Stephen John Wort
Guest Editors

Manuscript Submission Information

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Keywords

  • pulmonary heart disease
  • pulmonary hypertension
  • diagnosis
  • treatment
  • clinical advances

Published Papers (1 paper)

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Review

22 pages, 778 KiB  
Review
Endothelial Function in Pulmonary Arterial Hypertension: From Bench to Bedside
by Michele Correale, Francesco Chirivì, Ester Maria Lucia Bevere, Lucia Tricarico, Michele D’Alto, Roberto Badagliacca, Natale D. Brunetti, Carmine Dario Vizza and Stefano Ghio
J. Clin. Med. 2024, 13(8), 2444; https://doi.org/10.3390/jcm13082444 - 22 Apr 2024
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Abstract
Pulmonary arterial hypertension is a complex pathology whose etiology is still not completely well clarified. The pathogenesis of pulmonary arterial hypertension involves different molecular mechanisms, with endothelial dysfunction playing a central role in disease progression. Both individual genetic predispositions and environmental factors seem [...] Read more.
Pulmonary arterial hypertension is a complex pathology whose etiology is still not completely well clarified. The pathogenesis of pulmonary arterial hypertension involves different molecular mechanisms, with endothelial dysfunction playing a central role in disease progression. Both individual genetic predispositions and environmental factors seem to contribute to its onset. To further understand the complex relationship between endothelial and pulmonary hypertension and try to contribute to the development of future therapies, we report a comprehensive and updated review on endothelial function in pulmonary arterial hypertension. Full article
(This article belongs to the Special Issue Clinical Advances in Pulmonary Heart Disease)
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