Clinical Management of Acute Ischemic Stroke
Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 5100
Interests: stroke; thrombolysis; thrombectomy; post-stroke epilepsy
Interests: stroke; neuroimaging; neurointerventional; angiography; rare neurovascular disorders; small vessel disease
Special Issues, Collections and Topics in MDPI journals
Stroke is the second leading cause of death and a major cause of disability worldwide. Although recanalization therapy has changed the outcome for patients with acute ischemic stroke during the last decades, several issues remain unresolved and vascular neurology/neuroradiologists still wait for answers. Tenecteplase is a next-generation genetically modified rtPA and is currently the most promising alternative agent to alteplase. However, more data are needed and current European Stroke Organization guidelines for patients with AIS of < 4.5 hours duration who are not eligible for MT suggest intravenous thrombolysis with alteplase over tenecteplase. The best medical treatment for minor, non-disabling, ischemic stroke is yet unknown. Several patients with acute ischemic stroke due to large vessel occlusion can develop “futile” recanalization, i.e., a poor clinical outcome despite a successful recanalization of the occluded vessel. Mechanisms and predictors of “futile” recanalization remain largely unrecognized and deserve further evaluation. Moreover, the balance between benefit and harm in the selection of the patients for i.v. or endovascular reperfusion is still hard to assess in individual cases because of the presence of several grey areas (e.g., field and meaning of perfusion studies vs. collateral status evaluation, pure hemodynamic stroke in the setting of chronic large vessel occlusions, multiple simultaneous vessel occlusions, the opportunity to tailor the treatment to the cause of the stroke and not only to the site of vessel occlusion, etc.). Epileptic status after acute ischemic stroke represents an uncommon, but harmful, consequence. Little is known about the outcome of these patients in terms of disability and mortality. These issues, and many others, will be covered by review papers, clinical, and experimental studies in this Special Issue of the Journal of Clinical Medicine focused on the clinical management of acute ischemic stroke.
Dr. Giovanni Merlino
Dr. Maria Luisa Zedde
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- non-disabling ischemic stroke
- futile recanalization
- post-stroke epileptic status
- hemodynamic stroke
- intracranial stenosis